Çiğdem ELMAS, Latife SAKİNER, İrem Deniz BULUT, Perihan YALCİNKAYA

Effects of controlled ovarian hyperstimulation protocols on uterine markers

Controlled ovarian hyperstimulation is based on the development of multiple follicles in the same cycle as achieving the optimal number and quality of oocytes and is a common practice in infertility treatment. In this application, clomiphene citrate and gonadotropins are the most commonly used agents. These agents have some effects on reproductive tissues. Uterine tissue is susceptible to hormonal changes and undergoes a change in hormone action in terms of protein profile, secretory content and molecular structure during the menstrual cycle. In this review, it is aimed that controlled ovarian hyperstimulation has effect onfemale reproductive organs with different markers and methods, how to gather information about where the change occurs due to the functions of these markers, and to present this information to scientists working in the field by being related to each other. It is seen that controlled ovarian hyperstimulation may have negative effects on many functions such as uterine growth, receptivity, and altered expressions of the markers. Articles in this review, it is generally recognized that the expression of a majority of receptiveproteins is decreased, which is thought to have an adverse effect on live birth rates and infertility treatment. More clinical trials are needed for these markers in order to increase live birth rates, implant success and to develop infertility treatment.

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Ku SY, Choi YM, Suh CS, Kim SH, Kim JG, Moon SY, et al. Effect of superovulation on the expression of tissue inhibitor of metalloproteinase- 3 in the murine endometrium. Gynecol Obstet Invest 2003;55(1):1-6.
Leco KJ, Edwards DR, Schultz GA. Tissue inhibitor of metalloproteinases-3 is the major metalloproteinase inhibitor in the decidualizing murine uterus. Mol Reprod Dev 1996;45(4):458-65.
Noci I, Borri P, Coccia ME, Criscuoli L, Scarselli G, Messeri G, et al. Hormonal patterns, steroid receptors and morphological pictures of endometrium in hyperstimulated IVF cycles. Eur J Obstet Gynecol Reprod Biol 1997;75(2):215-20.
Bourgain C, Ubaldi F, Tavaniotou A, Smitz J, Steirtephem V, Devroey P. Endometrial hormone receptors and proliferation index in the periovulatory phase of stimulated embryo transfer cycles in comparison with natural cycles and relation to clinical pregnancy outcome. Fertil Steril 2002;78(2):237-44.
Chai J, Lee KF, Ng EH, Yeung WS, Ho PC. Ovarian stimulation modulates steroid receptor expression and spheroid attachment in peri-implantation endometria: studies on natural and stimulated cycles. Fertil Steril 2011;96(3):764-8.
Lin ZL, Ni HM, Liu YH, Sheng XH, Cui XS, Kim NH et al. Effect of anti-PMSG on distrubution of estrogen receptor alpha and progesterone receptor in Mouse ovary, oviduct and uterus. Zygote 2014;23(5):695-703.
Bayard F, Damılano S, Robel P, Baulieu EE. Cytoplasmic and nuclear estra- diol and progesterone receptors in human endometrium. J. Clin. Endocrinol. Metab 1978;46(4):635-48.
Lindsay LA, Murphy CR. Ovarian hyperstimulation affects fluid transporters in the uterus: A potential mechanism in uterine receptivity. Reprod Fertil Dev 2012;26(7):982-90.
Skowronski MT. Distribution and quantitative changes in amounts of aquaporin 1, 5 and 9 in the pig uterus during the estrous cycle and early pregnancy.Reprod Biol Endocrinol 2010;8:109.
Hildenbrand A, Lalitkumar L, Nielsen S, Gemzell-Danielsson K, Stavreus-Evers A. Expression of aquaporin 2 in human endometrium. Fertil Steril 2006;86(5):1452-8.
He RH, Sheng JZ, Luo Q, Jin F, Wang B, Qian YL et al. Aquaporin - 2 expression in human endometrium correlates with serum ovarian steroid hormones. Life Sci 2006;79(5):423-9.
He RH, Gao HJ, Li YQ, Zhu XM. The associated factors to endometrial cavity fluid and the relevant impact on the IVFET outcome.Reprod Biol Endocrinol 2010;8:46.
Jovanovic A, Kramer B. The effect of hyperstimulation on transforming growth factor b1 and b2 in the rat uterus: possible consequences for embryo implantation. Fertil Steril 2010;93(5):1509-17.
Ingman WV, Robertson SA. Defining the actions of TGF-b in reproduction.Bioessays 2002; 24(10):904-14.
Taylor HS, Igarashi P, Olive DL, Arici A. Sex steroids mediate HOXA11 expression in the human peri-implantation endometrium. J Clin Endocrinol Metab 1999;84(3):1129-35.
Chen Q, Sun X, Lı L, Gao X, Wu Y, Cheng L. Endometrial mucin-1 and pinopode in peri-implantation phase in ovarian high responders during controlled ovarian hyperstimulation cycles. J Reproduction Contraception 2007;18(3):187-96.
Devine PL, McKenzie IF. Mucins: structure, function, and associations with malignancy. Bioessays 1992;14(9):619-25.
Lai TH, ZhaoY, Shih IM, Ho CL, Bankowski B. Vlahos N. Expression of L-selectin ligands in human endometrium during the implantation window after controlled ovarian stimulation for oocyte donation. Fertil Steril 2006;85(3):761-3.
Lai TH, Shih IeM, Vlahos N, Ho CL, Wallach E, Zhao Y. Differential expression of L-selectin ligand in the endometrium during the menstrual cycle. Fertil Steril 2005;83(1):1297-302.
Xiong M, Zhang H, Jın L, Al J, Huang Z, Zhu G. Association of controlled ovarian hyperstimulation treatment with downregulation of key regulators involved in embryonic implantation in mice. J. Huazhong Univ Sci Technol Med Sci 2011;31(4):535-42.
Fujimoto J, Ichigo S, Hori M, Tamaya T. Alteration of E-cadherin, alpha - and beta - catenin mRNA expression in human uterine endometrium during the menstrual cycle. Gynecol Endocrinol 1996;10(3):187-91.
Van der Linden PJ, de Goeij AF, Dunselman GA, Erkens HW, Evers JL. Expression of cadherins and integrins in human endometrium throughout the menstrual cycle. Fertil Steril 1995;63(6):1210-6.
Damjanov I, Damjanov A, Damsky CH. Developmentally regulated expression of the cell-cell adhesion molecule cell - CAM 120/80 in peri-implantation mouse embryos. Dev Biol 1986;116(1):194-202.
Shirayoshi Y, Okada TS, Takeichi M. The calcium- dependent cell-cell adhesion systems regulates inner cell mass formation and cell surface polarization in early mouse development. Cell 1983;35(3 Pt 2): 631-8.
Thomas K, Thomson A, Vince G, Kingsland C, LevisJones I. Superovulation during IVF treatment: its effect on integrin expression and endometrial receptivity. Fertil Steril 2001;76(3):165-6.
Palomino WA, Fuentes A, Gonzalez RR, Gabler F, Boric MA, Vega M, et al. Differential expression of endometrial integrins and progesterone receptor during the window of implantation in normo -ovulatory women treated with clomiphene citrate. Fertil Steril 2005;83(3):587-93.
Zhang D, Xu G, Zhang R, Zhu Y, Gao H, Zhou C, et al. Decreased expression of aquaporin 2 is associated with impaired endometrial receptivity in controlled ovarian stimulation. Reproduction, Fertility and Development 2014;28(4).499-506.
Chen Q, Sun XX, Li L, Gao X, GemzellDanielsson K, Cheng LN. Effects of ovarian stimulation on endometrial integrin β3 and leukemia inhibitory factor expression in the periimplantation phase. Fertil Steril 2008;89(5):1357-63.
Thomas K, Thomson AJ, Sephton V, Cowan C, Wood S, Vince G, et al. The effect of gonadotrophic stimulation on integrin expression in the endometrium. Hum Reprod 2002;17(1):63-8.
Creus M, Ordi J, Fabreques F, Casamitjane R, Carmona F, Cardesa A, et al. The effect of different hormone therapies on integrin expression and pinopode formation in the human endometrium; a controlled study. Hum Reprod 2003;18(4):683-93.
Sendag F, Akdogan A, Ozbilgin K, Giray G, Oztekin K. Effect of ovarian stimulation with human menopausal gonadotropin and recombinant follicle stimulating hormone on the expression of integrins alpha(3), beta (1) in the rat endometrium during the implantation period. Eur J Obstet Gynecol Reprod Biol 2010;150(1):57-60.
Radwan DM. Comparative histological and immunohistochemical study on rat ovarian and endometrial responses to letrozole versus clomiphene citrate. Egypt. J. Histol 2010;33(3):594-606.
Ruan HC, Zhu XM, Luo Q, Liu AX, Qian YL, Zhou CY, et al. Ovarian stimulation with GnRH agonist, but not GnRH antagonist, partially restores the expression of endometrial integrin b3, and leukaemia-inhibitory factor and improves uterine receptivity in mice. Hum Reprod 2006;21(10):2521-9.
Srinivasan KR, Blesson CS, Fatima I, Kitchlu S, Jain SK, Mehrotra PK, et al. Expression of alphaVbeta3 integrin in rat endometrial epithelial cells and its functional role during implantation. Gen Comp Endocrinol 2009;160(2):124-33.
Kaneko Y, Day ML, Murphy CR. Integrin β3 in rat blastocysts and epithelial cells is essential for implantation in vitro: studies with Ishikawa cells and small interfering RNA transfection. Hum Reprod 2011;26(7):1665-74.
Illera MJ, Cullinan E, Gui Y, Yuan L, Beyler SA, Lessey BA. Blockade of the alpha (v) beta (3) integrin adversely affects implantation in the mouse. Biol Reprod 2000;62(5):1285-90.
Basak S, Dhar R, Das C. Steroids modulate the expression of alpha4 integrin in mouse blastocysts and uterus during implantation. Biology of Reproduction 2002;66(6):1784-9.
Lessey BA, Castelbaum AJ, Buck CA, Lei Y, Yowell CW, Sun J. Further characterization of endometrial integrins during the menstrual cycle and in pregnancy. Fertil Steril 1994;62(3):497-506.
Siristatidis C, Sergentanis TN, Kanavidis P, Trivella M, Sotiraki M, Mavromatis I, et al. Controlled ovarian hyperstimulation for IVF: impact on ovarian, endometrial and cervical cancer-a systematic review and meta-analysis. Hum Reprod Update 2013;19 (2):105-23.
Arslan M, Bocca S, Mirkin S, Barraso G, Stadtmauer L, Oehninger S. Controlled ovarian hyperstimulation protocols for in vitro fertilization: two decades of experience after the birth of Elizabeth Carr. Fertil Steril 2005;84(3):555-69.