Demographic characteristics of cases diagnosed with cleft palate

Demographic characteristics of cases diagnosed with cleft palate

Aim: The aim of this study is to retrospectively evaluate the cleft palate cases in our neonatal clinic and to examine the associatedclinical features, predisposing factors, accompanying anomalies, additional fidings, treatment approaches and follow-up results.Material and Methods: The study included babies that were diagnosed with cleft palate in our Neonatal Intensive Care Unit betweenJanuary 2014 and December 2018. The etiological risk factors, demographic characteristics, clinical features and concomitantmalformations of the patients included in the study were retrospectively recorded from the patient fies and the database system ofour hospital.Results: A total of 70 cleft palate patients were observed over a fie year period. Of these, 30 (42.9%) were female and 40 (57.1%)were male. The mean gestational age was 38 ± 2.9 weeks and the mean birth weight was 2845 ± 700 grams. 77.1% of the patientswere found to additionally have cleft lips. 27 patients (38.5%) had cardiac defects, 18 (25.7%) had central nervous system anomaliesand 4 (5.7%) had hypothyroidism. 24 (34.3%) of the parents were consanguineous. The median age at the time of the initial operationwas 13 months for cleft palate cases and 5 months for cleft lip cases.Conclusion: As a result, treatment and follow-up of patients with cleft palate defect requires a multidisciplinary approach. Thesepatients should undergo a thorough examination and evaluation. Since many syndromes or malformations may accompany thepalate defects, these cases should be investigated with respect to genetic disease and other system anomalies.

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  • 1. Georgiade GS, Georgiade NG, Riefkohl R, et al. Textbook of plastic maxillofacial and reconstructive surgery. Wiliams and Wilkins 1992;301-27.
  • 2. Mitchell LE, Rischt N. Mode of inheritance of nonsyndromic cleft lip with or without cleft palate: a reanalysis. Am J Hum Genet 1992;51:323-32.
  • 3. McCarthy JG, Cutting CB, Hogan VM: Introduction to facial clefis. In McCarthy JG (ed), Plastic Surgery, WB Saunders Co, Philadelphia 1990;2437-50.
  • 4. Wyszynski DF, Beaty TH and Maestri NE. Genetics of nonsyndromic oral clefts revisited. Cleft Palate-Cranio J 1996;33:406-17.
  • 5. Stainer P, Moore GE. Genetics of cleft lip and palate: syndromic genes contribute to the incidance of non- syndromic clefts. Human Molecular Genetics 2004; 1:13.
  • 6. Tunçbilek G, Özgür F, Balcı S. 1229 yarık dudak ve damak hastasında görülen ek malformasyon ve sendromlar. Çocuk Sağlığı ve Hastalıkları Dergisi 2004; 47:172-6.
  • 7. Göyenç Y, Karadede İ, Baran S, ve ark.Dudak damak yarıkları sınıflaması ve dağılım. İ.Ü. Diş Hekimliği Fakültesi Dergisi 1993;27:17-21.
  • 8. Mossey PA, Little J. Epidemiology of oral clefts: an international perspective. In: Wyszynski DF, ed. Cleft lip and palate: from origins to treatment. New York: Oxford University Press 2002;127-58.
  • 9. Milerad J, Larson O, Hagberg C, et al. Associated malformations in infants with cleft lip and palate-a prospective population based study. J Pediatr 1997;100:180-6.
  • 10. Corp I. B.M. (2013). IBM SPSS statistics for windows, version 22.0. Armonk, NY: IBM Corp.
  • 11. Rajesh P, Rajesh R, Narayanan V, et al. A clinical profie to assess the potential risk factors for cleft lip and palate. J Indian Soc Pedod Prev Dent 2000;18:147-50.
  • 12. Bender PL. Genetics of cleft lip and palate. J Pediatr Nurs 2000;15:242-9.
  • 13. Murray JC. Gene/environment causes of cleft lip and/ or palate. Clin Genet 2002;61:248-56.
  • 14. Johnson DD, Pretorius DH, Budorick NE, et al. Fetal lip and primary palate: Three-dimensional versus twodimensional us. Radiology 2000;217:236-9.
  • 15. Hoşnuter M, Aktunç E, Kargı E ve ark. Yarık damak dudak aile rehberi. Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi 2002;9:9-13.
  • 16. Borcbakan C. An analysis of 1000 cases of cleft lip and palate in Turkey. Cleft Palate J 1969;6:210-2.
  • 17. Anastassov GE, Joos U. Comprehensive management of cleft lip and palate deformities. J Oral Maxillofac Surg 2001;59:1062-75.
  • 18. Osuji OO. Preparation of feeding obturators for infants with cleft lip and palate. J Clin Pediatr Dent 1995;19:211-4.
Annals of Medical Research-Cover
  • Yayın Aralığı: Aylık
  • Yayıncı: İnönü Üniversitesi Tıp Fakültesi
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