Investigating neutrophil-to-eosinophil ratio and variations in eosinophil levels in epilepsy patients with generalized tonic-clonic seizures

Investigating neutrophil-to-eosinophil ratio and variations in eosinophil levels in epilepsy patients with generalized tonic-clonic seizures

Aim: Neutrophil-to-eosinophil ratio (NER) shows inflammation, which can play a role in the development of some epilepsies andictogenesis. The current study aimed to investigate the NER and the variations in neutrophil and eosinophil levels in epilepsy patientswith generalized tonic-clonic seizures.Material and Methods: Epilepsy patients with generalized tonic-clonic seizures were retrospectively evaluated in the present study.Laboratory parameters of the patients in the acute (within 6 hours after the seizure) and subacute (on day 5 after the seizure) phaseswere compared.Results: 60 patients (30 males and 30 females) who had generalized tonic-clonic epileptic seizures were included in the study. Themedian neutrophil count and NER were signifiantly higher in the acute phase than in the subacute phase (p

___

  • 1. Panayiotopoulos CP. The new ILAE report on terminology and concepts for the organization of epilepsies: critical review and contribution. Epilepsia 2012;53:399-404.
  • 2. Holmes GL. Seizure-induced neuronal injury: animal data. Neurology 2002;59:3-6.
  • 3. Chang HJ, Liao CC, Hu CJ, et al. Psychiatric disorders after epilepsy diagnosis: a population-based retrospective cohort study. PLoS One 2013;8:59999.
  • 4. Salas-Puig X, Iniesta M, Abraira L, et al; QUIN-GTC study group. Accidental injuries in patients with generalized tonic-clonic seizures. A multicenter, observational, cross-sectional study (QUIN-GTC study). Epilepsy Behav 2019;92:135-9.
  • 5. Sagduyu A, Tarlaci S, Sirin H. Generalized tonicclonic status epilepticus: causes, treatment, complications and predictors of case fatality. J Neurol 1998;245: 640-6.
  • 6. Ferlisi M, Shorvon S. Seizure precipitants (triggering factors) in patients with epilepsy. Epilepsy Behav 2014;33:101-5.
  • 7. Kasteleijn-Nolst Trenité DG. Provoked and reflex seizures: surprising or common? Epilepsia 2012;53:105-13.
  • 8. Yigit Y, Yilmaz S, Akdogan A, et al. The role of neutrophil-lymphocyte ratio and red blood cell distribution width in the classifiation of febrile seizures. Eur Rev Med Pharmacol Sci 2017;21:554-9.
  • 9. Ozdemir HH, Akil E, Acar A, et al. Changes in serum albumin levels and neutrophil-lymphocyte ratio in patients with convulsive status epilepticus. Int J Neurosci 2017;127:417-20.
  • 10. Marchi N, Fan Q, Ghosh C, et al. Antagonism of peripheral inflammation reduces the severity of status epilepticus. Neurobiol Dis 2009;33:171-81.
  • 11. Sutter R, Grize L, Fuhr P, et al. Acute-phase proteins and mortality in status epilepticus: a 5 year observational cohort study. Crit Care Med 2013;41:1526-33.
  • 12. Marchi N, Granata T, Janigro D. Inflammatory pathways of seizure disorders. Trends Neurosci 2014;37:55-65.
  • 13. Marchi N, Granata T, Freri E, et al. Effiacy of antiinflammatory therapy in a model of acute seizures and in a population of pediatric drug resistant epileptics. PLoS One 2011;28:18200.
  • 14. Vezzani A, Maroso M, Balosso S, et al. IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures. Brain Behav Immun 2011;25:1281-9.
  • 15. Noe FM, Polascheck N, Frigerio F,et al. Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy. Neurobiol Dis 2013;59:183-93.
  • 16. DeSena AD, Do T, Schulert GS. Systemic autoinflammation with intractable epilepsy managed with interleukin-1 blockade. J Neuroinflammation 2018;15:38.
  • 17. Rosales C. Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types? Front Physiol 2018;9:113.
  • 18. Davido B, Makhlouf S, Matt M, et al. Changes in eosinophil count during bacterial infection: revisiting an old marker to assess the effiacy of antimicrobial therapy. Int J Infect Dis 2017;61:62-6.
  • 19. Debray A, Nathanson S, Moulin F, et al. Eosinopenia as a marker of diagnosis and prognostic to distinguish bacterial from aseptic meningitis in pediatrics. Eur J Clin Microbiol Infect Dis 2019;38:1821-7.
  • 20. Gil H, Bouldoires B, Bailly B, et al. [Eosinopenia in 2018]. Rev Med Interne 2019;40:173-7.
  • 21. Zhao HM, Qin WQ, Wang PJ, et al. Eosinopenia is a predictive factor for the severity of acute ischemic stroke. Neural Regen Res 2019;14:1772-9.
  • 22. Hori YS, Kodera S, Sato Y, et al. Eosinopenia as a Predictive Factor of the Short-Term Risk of Mortality and Infection after Acute Cerebral Infarction. J Stroke Cerebrovasc Dis 2016;25:1307-12.
  • 23. Bolayir A, Cigdem B, Gokce SF, et al. The Effect of Eosinopenia on Mortality in Patients with Intracerebral Hemorrhage. J Stroke Cerebrovasc Dis 2017;26:2248- 55.
  • 24. Brenner DR, Scherer D, Muir K, et al. A review of the application of inflammatory biomarkers in epidemiologic cancer research. Cancer Epidemiol Biomarkers Prev 2014;23:1729-51.
  • 25. Sohn HS, Kim SK, Lee SY. Inflammatory markers associated with seizures. Epileptic Disord 2016;18:51-7.
Annals of Medical Research-Cover
  • Yayın Aralığı: Aylık
  • Yayıncı: İnönü Üniversitesi Tıp Fakültesi
Sayıdaki Diğer Makaleler

Comparison of acute kidney injury after zero ischemia robot-assisted partial nephrectomy versus open and laparoscopic partial nephrectomy in patients with renal mass

Burak KÖPRÜ, Turgay EBİLOĞLU, Giray ERGİN, Mustafa KIRAÇ, Yusuf KİBAR, Hasan BİRİ

Wandering spleen torsion resulted as intestinal obstruction

Aytaç TAŞÇI, Turan YILDIZ

The nomograms of sonographic measurements of the liver, spleen, and kidney in preterm and term neonates

Mehmet Burak ÖZKAN

Gender differences between the three dimensional gait analysis data of young athletes

Dilek ÖZTAŞ, İlhan Avni BAYHAN, Canan Gönen AYDIN, Hanife Hale HEKİM, Hanefi ÜÇPINAR

eNOS gene polymorphısms and transıtıonal cell cancer of the bladder

Aziz TOKER, Erkan ERKAN, Uğur YÜCETAŞ, Fatma Sinem Hocaoğlu EMRE

Relation between the attitudes of nursing students on gender equality and dating violence

Rabiye ERENOĞLU, Nevin USLU

Can immature reticulocyte fraction be an inflammatory biomarker in late-preterm infants diagnosed with congenital pneumonia?

Canan BAYDEMİR, İlkay ER, Ceren ÇETİN

Normative data for trachea and main bronchi dimensions on computed tomography in children and adolescents

Mehmet ÖZTÜRK, Emine ÇALIŞKAN, Ozan Berk GÜL

Investigation of the effectiveness of physical examination and radiologıcal imaging methods in the diagnosis of nasal bone fractures

Sermin Tok UMAY, Ahmet MUSMUL, Onur ERDOĞAN, Sinem Gökçe KÜTÜK, Muhammet Fatih TOPUZ, Fatih OĞHAN

The diagnostic value of adrenomedullin and its relation with severity in patients with systolic heart failure

Abdulbaki KUMBASAR, Nilgün YILDIRIM