Muzaffer GÜNEŞ

Investigating neutrophil-to-eosinophil ratio and variations in eosinophil levels in epilepsy patients with generalized tonic-clonic seizures

Aim: Neutrophil-to-eosinophil ratio (NER) shows inflammation, which can play a role in the development of some epilepsies andictogenesis. The current study aimed to investigate the NER and the variations in neutrophil and eosinophil levels in epilepsy patientswith generalized tonic-clonic seizures.Material and Methods: Epilepsy patients with generalized tonic-clonic seizures were retrospectively evaluated in the present study.Laboratory parameters of the patients in the acute (within 6 hours after the seizure) and subacute (on day 5 after the seizure) phaseswere compared.Results: 60 patients (30 males and 30 females) who had generalized tonic-clonic epileptic seizures were included in the study. Themedian neutrophil count and NER were signifiantly higher in the acute phase than in the subacute phase (p

PDF

___

1. Panayiotopoulos CP. The new ILAE report on terminology and concepts for the organization of epilepsies: critical review and contribution. Epilepsia 2012;53:399-404.
2. Holmes GL. Seizure-induced neuronal injury: animal data. Neurology 2002;59:3-6.
3. Chang HJ, Liao CC, Hu CJ, et al. Psychiatric disorders after epilepsy diagnosis: a population-based retrospective cohort study. PLoS One 2013;8:59999.
4. Salas-Puig X, Iniesta M, Abraira L, et al; QUIN-GTC study group. Accidental injuries in patients with generalized tonic-clonic seizures. A multicenter, observational, cross-sectional study (QUIN-GTC study). Epilepsy Behav 2019;92:135-9.
5. Sagduyu A, Tarlaci S, Sirin H. Generalized tonicclonic status epilepticus: causes, treatment, complications and predictors of case fatality. J Neurol 1998;245: 640-6.
6. Ferlisi M, Shorvon S. Seizure precipitants (triggering factors) in patients with epilepsy. Epilepsy Behav 2014;33:101-5.
7. Kasteleijn-Nolst Trenité DG. Provoked and reflex seizures: surprising or common? Epilepsia 2012;53:105-13.
8. Yigit Y, Yilmaz S, Akdogan A, et al. The role of neutrophil-lymphocyte ratio and red blood cell distribution width in the classifiation of febrile seizures. Eur Rev Med Pharmacol Sci 2017;21:554-9.
9. Ozdemir HH, Akil E, Acar A, et al. Changes in serum albumin levels and neutrophil-lymphocyte ratio in patients with convulsive status epilepticus. Int J Neurosci 2017;127:417-20.
10. Marchi N, Fan Q, Ghosh C, et al. Antagonism of peripheral inflammation reduces the severity of status epilepticus. Neurobiol Dis 2009;33:171-81.
11. Sutter R, Grize L, Fuhr P, et al. Acute-phase proteins and mortality in status epilepticus: a 5 year observational cohort study. Crit Care Med 2013;41:1526-33.
12. Marchi N, Granata T, Janigro D. Inflammatory pathways of seizure disorders. Trends Neurosci 2014;37:55-65.
13. Marchi N, Granata T, Freri E, et al. Effiacy of antiinflammatory therapy in a model of acute seizures and in a population of pediatric drug resistant epileptics. PLoS One 2011;28:18200.
14. Vezzani A, Maroso M, Balosso S, et al. IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures. Brain Behav Immun 2011;25:1281-9.
15. Noe FM, Polascheck N, Frigerio F,et al. Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy. Neurobiol Dis 2013;59:183-93.
16. DeSena AD, Do T, Schulert GS. Systemic autoinflammation with intractable epilepsy managed with interleukin-1 blockade. J Neuroinflammation 2018;15:38.
17. Rosales C. Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types? Front Physiol 2018;9:113.
18. Davido B, Makhlouf S, Matt M, et al. Changes in eosinophil count during bacterial infection: revisiting an old marker to assess the effiacy of antimicrobial therapy. Int J Infect Dis 2017;61:62-6.
19. Debray A, Nathanson S, Moulin F, et al. Eosinopenia as a marker of diagnosis and prognostic to distinguish bacterial from aseptic meningitis in pediatrics. Eur J Clin Microbiol Infect Dis 2019;38:1821-7.
20. Gil H, Bouldoires B, Bailly B, et al. [Eosinopenia in 2018]. Rev Med Interne 2019;40:173-7.
21. Zhao HM, Qin WQ, Wang PJ, et al. Eosinopenia is a predictive factor for the severity of acute ischemic stroke. Neural Regen Res 2019;14:1772-9.
22. Hori YS, Kodera S, Sato Y, et al. Eosinopenia as a Predictive Factor of the Short-Term Risk of Mortality and Infection after Acute Cerebral Infarction. J Stroke Cerebrovasc Dis 2016;25:1307-12.
23. Bolayir A, Cigdem B, Gokce SF, et al. The Effect of Eosinopenia on Mortality in Patients with Intracerebral Hemorrhage. J Stroke Cerebrovasc Dis 2017;26:2248- 55.
24. Brenner DR, Scherer D, Muir K, et al. A review of the application of inflammatory biomarkers in epidemiologic cancer research. Cancer Epidemiol Biomarkers Prev 2014;23:1729-51.
25. Sohn HS, Kim SK, Lee SY. Inflammatory markers associated with seizures. Epileptic Disord 2016;18:51-7.