Circulation levels of YKL-40 and Hs-CRP in stage 3 Molar-incisor pattern of periodontitis

Aim: To evaluate the novel acute phase protein YKL-40 and high-sensitive C-reactive protein (Hs-CRP) in serum of patients withmolar-incisor pattern of periodontitis (Stage 3, Grade C).Material and Methods: Twenty seven patients with molar-incisor pattern of periodontitis and 27 periodontally healthy individualswere included into the study. Serum levels of YKL-40 and Hs-CRP were measured by enzyme-linked immunosorbent assay.Results: Serum YKL-40 levels were significantly increased in molar-incisor pattern of periodontitis patients compared to healthycontrols (P

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1. Kornman KS. Mapping the pathogenesis of periodontitis: a new look. J Periodontol 2008;79:1560- 8.
2. Lang N, Bartold PM, Cullinan M. Consensus report - aggressive periodontitis. Ann Periodontol 1999;4:53.
3. Tonetti MS, Mombelli A. Early-onset periodontitis. Ann Periodontol 1999;4:39-53.
4. Fine DH, Patil AG, Loos BG. Classification and diagnosis of aggressive periodontitis. J Periodontol 2018;89:103-19.
5. Fine DH, Armitage GC, Genco RJ, et al. Unique etiologic, demographic, and pathologic characteristics of localized aggressive periodontitis support classification as a distinct subcategory of periodontitis. J Am Dent Assoc 2019;150:922-31.
6. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999;4:1-6.
7. Papapanou PN, Sanz M, Buduneli N, et al. Periodontitis: consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Clin Periodontol 2018;45:162-70.
8. Harris TH, Wallace MR, Huang H, et al. Association of P2RX7 functional variants with localized aggressive periodontitis. J Periodont Res 2019;00:1-9.
9. Houri-Haddad Y, Wilensky A, Shapira L. T-cell phenotype as a risk factor for periodontal disease. Periodontol 2000 2007;45:67-75.
10. Shaddox L, Wiedey J, Bimstein E, et al. Hyperresponsive phenotype in localized aggressive periodontitis. J Dent Res 2010;89:143-8.
11. Martins ES, César-Neto JB, Albuquerque-Souza E, et al. One-year follow-up of the immune profile in serum and selected sites of generalized and localized aggressive periodontitis. Cytokine 2019;116:27-37.
12. Loos BG, Craandijk J, Hoek FJ, et al. Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. J Periodontol 2000;71:1528-34.
13. Salzberg TN, Overstreet BT, Rogers JD, et al. C-reactive protein levels in patients with aggressive periodontitis. J Periodontol 2006;77:933-9.
14. Mysak J, Podzimek S, Vasakova J, et al. C-reactive protein in patients with aggressive periodontitis. J Dent Sci 2017;12:368-74.
15. Koj A. Initiation of acute phase response and synthesis of cytokines. Biochim Biophys Acta 1996;1317:84-94.
16. Gruys E, Toussaint MJ, Niewold TA, et al. Acute phase reaction and acute phase proteins. J Zhejiang Univ Sci B 2005;6:1045-56.
17. Gomes-Filho IS, Coelho JMF, da Cruz SS, et al. Chronic periodontitis and C-reactive protein levels. J Periodontol 2011;82:969-78.
18. Chopra R, Patil SR, Kalburgi NB, et al. Association between alveolar bone loss and serum C-reactive protein levels in aggressive and chronic periodontitis patients. J Indian Soc Periodontol 2012;16:28-31.
19. Slade GD, Offenbacher S, Beck JD, et al. Acute-phase inflammatory response to periodontal disease in the US population. J Dent Res 2000;79:49-57.
20. Noack B, Genco RJ, Trevisan M, et al. Periodontal infections contribute to elevated systemic C-reactive protein level. J Periodontol 2001;72:1221-7.
21. Wohlfeil M, Scharf S, Siegelin Y, et al. Increased systemic elastase and C-reactive protein in aggressive periodontitis (CLOI-D-0160R2). Clin Oral Investig 2012;16:1199-207.
22. Chandy S, Joseph K, Sankaranarayanan A, et al. Evaluation of C-Reactive Protein and Fibrinogen in Patients with Chronic and Aggressive Periodontitis: A Clinico-Biochemical Study. J Clin Diagn Res 2017;11:41-5.
23. Kazakova M, Batalov A, Deneva T, et al. Relationship between sonographic parameters and YKL-40 levels in rheumatoid arthritis. Rheumatol Int 2013;33:341-6.
24. Mygind ND, Harutyunyan MJ, Mathiasen AB, et al; CLARICOR Trial Group. The influence of statin treatment on the inflammatory biomarkers YKL-40 and HsCRP in patients with stable coronary artery disease. Inflamm Res 2011;60:281-7.
25. Rathcke CN, Vestergaard H. YKL-40, a new inflammatory marker with relation to insulin resistance and with a role in endothelial dysfunction and atherosclerosis. Inflamm Res 2006;55:221-7.
26. Kastrup J. Can YKL-40 be a new inflammatory biomarker in cardiovascular disease? Immunobiology 2012;217:483-91.
27. Peltomaa R, Paimela L, Harvey S, et al. Increased level of YKL-40 in sera from patients with early rheumatoid arthritis: A new marker for disease activity. Rheumatol Int 2001;20:192-6.
28. Keles ZP, Keles GC, Avci B, et al. Analysis of YKL40 acute-phase protein and interleukin-6 levels in periodontal disease. J Periodontol 2014;85:1240-6.
29. Kido J, Bando Y, Bando M, et al. YKL-40 level in gingival crevicular fluid from patients with periodontitis and type 2 diabetes. Oral Dis 2015;21:667-73.
30. Damodar S, Mehta DS. Effect of scaling and root planing on gingival crevicular fluid of YKL-40 acute phase protein in chronic periodontitis patients with or without type 2 diabetes mellitus: A clinico-biochemical study. J Indian Soc Periodontol 2018;22:40-4.
31. Glurich I, Grossi S, Albini B, et al. Systemic inflammation in cardiovascular and periodontal disease: Comparative study. Clin Diagn Lab Immunol 2002;9:425-32.
32. Löe H, Silness J. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand 1963;21:533-51.
33. Silness J, Löe H. Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand 1964;22:121-35.
34. Ainamo J, Bay I. Problems and proposals for recording gingivitis and plaque. Int Dent J 1975;25:229-35.
35. Miyashita H, Honda T, Maekawa T, et al. Relationship between serum antibody titres to Porphyromonas gingivalis and hs-CRP levels as inflammatory markers of periodontitis. Arch Oral Biol 2012;57:820-9.
36. Nordenbaek C, Johansen JS, Junker P, et al. YKL-40, a matrix protein of specific granules in neutrophils, is elevated in serum of patients with communityacquired pneumonia requiring hospitalization. J Infect Dis 1999;180:1722-6.