Leukonychia is the most common nail change in Alopecia areata patients: A retrospective study in 207 patients

Aim: Alopecia areata is an auto-immune skin disease characterized by non-scarring hair loss. Nail changes are strongly associatedwith prognosis. In patients with Alopecia areata, the nail examination should not be neglected for an optimal follow-up.Material and Methods: A retrospective study involving 207 patients with Alopecia areata was undertaken in a tertiary hospitalbetween April 2016 and May 2017. Patients whose nail changes were registered in the database were included in the study. Gender,age, disease severity, sites affected, and nail changes of those patients were noted.Results: 114 patients (55%) had nail involvement. The most common nail finding was leukonychia (n = 84). Nail pitting was detectedin 29 patients.11 patients had both leukonychia and nail pitting. The mean age of the patients with leukonychia was 23.3, while themean age of nail pitting patients was 31.7 and the mean age of the patients without nail change was 34.1.Conclusion: Leukonychia is the most common nail change in this study, as a different finding from all previous studies

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1. Pratt CH, King LE Jr, Messenger AG, ET AL. Nat Rev Dis Primers 2017;3:17011.
2. Seetharam KA. Alopecia areata: an update. Indian J Dermatol Venereol Leprol 2013;79:563-75.
3. Chelidze K, Lipner SR. Nail changes in alopecia areata: an update and review. Int J Dermatol 2018;57:776-83.
4. Darwin E, Hirt PA, Fertig R, et al. alopecia areata: review of epidemiology, clinical features, pathogenesis, and new treatment options. Int J Trichology 2018;10:51-60.
5. Spano F, Donovan JC. Alopecia areata: part 1: pathogenesis, diagnosis, and prognosis. Can Fam Physician 2015;61:751-5.
6. You HR, Kim SJ. Factors associated with Severity of Alopecia Areata. Ann Dermatol 2017;29:565-70.
7. Alkhalifah A, Alsantali A, Wang E, et al. Alopecia areata update: part I. Clinical picture, histopathology, and pathogenesis. J Am Acad Dermatol 2010;62:177-88.
8. Roest YBM, van Middendorp HT, Evers AWM, et al. Nail involvement in alopecia areata: a questionnaire-based survey on clinical signs, impact on quality of life and review of the literature. Acta Derm Venereol 2018;98:212-7.
9. You HR, Kim SJ. Factors associated with severity of alopecia areata. Ann Dermatol 2017;29:565-70.
10. Kavak A, Yeşildal N, Parlak AH, et al. Alopecia areata in Turkey: demographic and clinical features. J Eur Acad Dermatol Venereol 2008;22:977-81.
11. Ranawaka RR. An observational study of alopecia areata in Sri Lankan adult patients. Ceylon Med J 2014;59:128-31.
12. Mirzoyev SA, Schrum AG, Davis MDP, et al. Lifetime incidence risk of alopecia areata estimated at 2.1% by rochester epidemiology project, 1990-2009. J Invest Dermatol 2014;134:1141-2.
13. Gandhi V, Baruah MC, Bhattacharaya SN. Nail changes in alopecia areata: incidence and pattern. Indian J Dermatol Venereol Leprol 2003;69:114-5.
14. Tosti A, Morelli R, Bardazzi F, et al. Prevalence of nail abnormalities in children with alopecia areata. Pediatr Dermatol 1994;11:112-5.
15. Sharma VK, Dawn G, Kumar B. Profile of alopecia areata in Northern India. Int J Dermatol 1996;35:22-7.
16. Singh SK. Finger nail pitting in psoriasis and its relation with different variables. Indian J Dermatol 2013;58:310-2.
17. Lundin M, Chawa S, Sachdev A, et al. Gender differences in alopecia areata. J Drugs Dermatol 2014;13:409-13.
18. Saray Y, Gulec T. Nail findings in alopecia areata:a casecontrol study. Turkiye Klinikleri J Dermatol 2004;14:61-5.
19. Dogan S, Ersoy-Evans S, Gonc N, et al. Childhood alopecia areata: a study of 89 patients. Turkderm 2014;48:135-9.
20. Tan E, Tay YK, Goh CL, et al. The pattern and pofile of alopecia areata in Singapore--a study of 219 Asians. Int J Dermatol 2002;41:748-53.
21. Lazzarini R, Oliari CB, Erthal, et al. Late-onset alopecia areata: descriptive analysis of 30 cases. An Bras Dermatol 2016;91:844-5.
22. Kasumagic-Halilovic E, Prohic A. Nail changes in alopecia areata: frequency and clinical presentation. J Eur Acad Dermatol Venereol 2009;23:240-1.
23. Al-Mutairi N, Eldin ON. Clinical profile and impact on quality of life: seven years experience with patients of alopecia areata.Indian J Dermatol Venereol Leprol 2011;77:489-93.
24. Roest YBM, van Middendorp HT, Evers AWM, et al. Nail involvement in alopecia areata: a questionnaire-based survey on clinical signs, impact on quality of life and review of the literature. Acta Derm Venereol 2018;98:212-7.
25. Dotz WI, Lieber CD, Vogt PJ. Leukonychia punctata and pitted nails in alopecia areata. Arch Dermatol 1985;121:1452-4.
26. Bongiorno MR, Aricò M. Idiopathic acquired leukonychia in a 34-year-old patient. Case Rep Med 2009;2009:495809.
27. Hegde SP, Naveen KN, Athanikar SB, et al. Clinical and dermatoscopic patterns of alopecia areata: a tertiary care centre experience. Int J Trichology 2013;5:132-6.