Bisfenol A: Maruziyeti, Metabolizması ve Toksik Etkileri

Gıda paketlerinde, konservelerde, kişisel bakım ürünlerinde, diş malzemelerinde ve günlük hayatta kullandığımız pek çok üründe bulunan Bisfenol A BPA gibi ksenobiyotikler, insan sağlığı için büyük tehdit oluşturmaktadır. Son yıllarda bu sentetik polimer üzerine yapılan çalışmalar, BPA maruziyetinin üreme sistemi, hormonal denge, pubertal gelişim üzerindeki yıkıcı etkilerini araştırmaktadır. Bu derlemede BPA maruziyetinin etki mekanizması ve insan vücudunda yarattığı tahribat üzerine yapılan çalışmalar özetlenmiş olup, günlük hayattaki BPA maruziyeti hakkında farkındalık oluşturmak amaçlanmıştır

Anahtar Kelimeler:

Ksenoöstrojen, Bisfenol A, Yemek, Endokrin Sistem

Bisphenol A: Exposure Routes, Metabolism and Toxicity

Many products that we use in daily life such as packaged or canned foods, personal care products, dental materials contain Bisphenol A BPA as a xenobiotic which is one of the major threat to human health. In recent years, the studies on these synthetic polymers search for the devastating effects of the BPA exposure on reproductive system, hormon balance, pubertal development. In the present review, we summarized the relevant literature about the action mechanism of BPA exposure and its destroying effects on human body. Furthermore we aimed to raise awareness about BPA exposure in daily life

Keywords:

Xenoestrogens, Bisphenol A, Food, Endocrine System,

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1. Mishra VN. Xenoestrogens: The Curse of Civilization. Medicine Update 2013; 23: 1e.
2. Michalowicz J. Bisphenol A – Sources, toxicity and biotransformation. Environ Toxicol Pharmacol 2014; 37: 738–58.
3. Careghini A, Mastorgio AF, Saponaro S,Sezenna E. Bisphenol a, nonylphenols, benzophenones, and benzotriazoles in soils, groundwater, surface water, sediments, and food: a review. Environ Sci Pollut Res 2015; 22: 5711–41.
4. Akyuz S, Yarat A, Egil E. Bisfenol-A İcerikli Dental Materyallere Güncel Yaklaşım. MUSBED 2011; 1(3): 190-5.
5. Quitmeyer A, Roberts R. Babies, Bottles, and Bisphenol A: The Story of a Scientist-Mother. PLoS Biol 2007; 5(7): e200.
6. Rosenfeld CS. Bisphenol A and phthalate endocrine disruption of parental and social behaviors. Front Neurosci 2015; 9: 57.
7. Wadia PR, Cabaton NJ, Borrero MD, Rubin BS, Sonnenschein C. Low-Dose BPA Exposure Alters the Mesenchymal and Epithelial Transcriptomes of the Mouse Fetal Mammary Gland. PLOS ONE 2013; 8(5): e63902.
8. Larsson K, Björklund KL, Palm B, Wennberg M, Kaj L, Lindh H, Jönsson Bo AG, Berglund M. Exposure determinants of phthalates, parabens, bisphenol A and triclosan in Swedish mothers and their children. Environ Int 2014; 73: 323–33.
9. Gao X, Wang HS. Impact of bisphenol a on the cardiovascular system - epidemiological and experimental evidence and molecular mechanisms. Int J Environ Res Public Health 2014; 11(8): 8399-413.
10. Kharrazian D. The Potential Roles of Bisphenol A (BPA) Pathogenesis in Autoimmunity. Hindawi Publishing Corporation Autoimmune Diseases 2014; Article ID 743616.
11. Cespedes R, Lacorte S, Raldua D, Ginebreda A, Barcelo D, Pina B. Distribution of endocrine disruptors in the Llobregat River basin (Catalonia, NE Spain). Chemosphere 2005; 61: 1710-19.
12. Hoekstra EJ, Simoneau C. Release of Bisphenol A from Polycarbonate-A Review. Crit Rev Food Sci Nutr 2013; 53: 386–402.
13. World Health Organization, Bisphenol A- Current State of Knowledge and Future Actions by WHO and FAO. INFOSAN 2009; 5.
14. Durmaz E, Giray BK. Çevresel bir endokrin bozucu: Bisfenol A ve toksik etkilerinin değerlendirilmesi. Çocuk Sağlığı ve Hastalıkları Dergisi 2013; 56: 192-9.
15. Andersona DJ, Brozeka EM, Coxb KJ, Porucznik CB, Wilkinsa DG. Biomonitoring method for bisphenol A in human urine by ultrahighperformance liquid chromatography-tandem mass spectrometry. Chromatogr B Analyt Technol Biomed Life Sci 2014; 953: 53–61.
16. Bushnik T, Haines D, Levallois P, Levesque J, Oostdam JV, Viau C. Lead and bisphenol A concentrations in the Canadian population. Health Reports 2010; 21: 3.
17. Lee HS, Parka EJ, Oha JH, Moona G, Hwanga MS, Kima SY, Shina MK, Koha YH, Suha, JH, Kanga HS, Jeon JH, Rheea GS, Hong JH. Bisphenol A exerts estrogenic effects by modulating CDK1/2 and p38 MAP kinase activity. Biosci Biotechnol Biochem 2014; 78(8): 1371–5.
18. Rochester JR. Bisphenol A and human health: A review of the literature. Reprod Toxicol 2013; 42: 132– 55.
19. Izzotti A, Kanitz Z, D’Agostini F, Camoirano A, De Flora S. Formation of adducts by bisphenol A, an endocrine disruptor, in DNA in vitro and in liver and mammary tissue of mice. Mutat Res/Genet Toxicol Environ Mutagen 2009; 679: 28-32.
20. Rezg R, El-Fazaa S, Gharbi N, Mornagu B, Rezg R. Bisphenol A and human chronic diseases: Current evidences, possible mechanisms, and future perspectives. Environ Int 2014; 64: 83–90.
21. Alonso-Magdalena P, Ropero AB, Soriano S, García-Arévalo M, Ripoll C, Fuentes E, Quesada I, Nadal A. Bisphenol-A acts as a potent estrogen via non-classical estrogen triggered pathways. Mol Cell Endocrinol 2012; 355: 201–7.
22. Marmugi A, Lasserre F, Beuzelin D, Ducheix S, Huc L, Polizzi A, Chetivaux M, Pineau T, Martin P, Guillou H, Mselli-Lakhal L. Toxicology 2014; 325: 133–43.
23. Bodin J, Bolling AK, Samuelsen M, Becher R, Lovik M, Nygaard UC. Long-term bisphenol A exposure accelerates insulitis development in diabetes-prone NOD mice. Immunopharmacol Immunotoxicol 2013; 35(3): 349–58.
24. LaKind JS, Goodman M, Mattison DR. Bisphenol A and indicators of obesity, glucose metabolism/type 2 diabetes and cardiovascular disease: A systematic review of epidemiologic research. Crit Rev Toxicol 2014; 44(2): 121–50.
25. vom Saal FS, Nagel SC, Coe BL, Angle BM, Taylor JA. The estrogenic endocrine disrupting chemical bisphenol A (BPA) and obesity. Mol Cell Endocrinol 2012; 354: 74–84.
26. Carwile JL, Michels KB. Urinary bisphenol A and obesity: NHANES 2003–2006. Environ Res 2011; 111: 825–30.
27. Wisniewski P, Romano RM, Kizys MML, Oliveira KC, Kasamatsu T, Giannocco G, Chiamolera MI, Dias-da-Silva MR,Romano MA. Adult exposure to bisphenol A (BPA) in Wistar rats reduces sperm quality with disruption of the hypothalamic–pituitary–testicular axis. Toxicology 2015; 329: 1–9.
28. Gao H, Yang BJ, Li N, Feng LM, Shi XY, Zhao WH, Liu SJ. Bisphenol A and HormoneAssociated Cancers: Curr Prog Perspect Med 2015; 94(1): e211.
29. Corbel T, Gayrard V, Viguie C, Puel S, Lacroix MZ, Toutain PL, Picard-Hagen N. Bisphenol A Disposition in the Sheep Maternal-Placental-Fetal Unit: Mechanisms Determining Fetal Internal Exposure. Biol Reprod 2013; 89(1): 1–9.
30. vom Saal FS, VandeVoort CA, Taylora JA, Welshonsd WV, Toutaine PL, Hunt PA. Bisphenol A (BPA) pharmacokinetics with daily oral bolus orcontinuous exposure via silastic capsules in pregnant rhesusmonkeys: Relevance for human exposures. Reprod Toxicol 2014; 45: 105-16.
31. Matsumura Y, Moriya A, Sasaki-Mori M. Bioremediation of Bisphenol A Polluted Soil by Sphingomonas bisphenolicum AO1 and the Microbial Community Exisiting in the Soil. Biocontrol Sci 2015; 20(1): 35-42
32. Konieczna A, Rutkowska A, Rachon D. Health Rısk of Exposure To Bısphenol A (Bpa). Rocz Panstw Zakl Hig 2015; 66(1): 5-11.
33. Shin E, Choi H, Song H. Biodegradation of endocrine-disrupting BPA by white rot fungus Irpex lacteus. J Microbiol Biotechnol 2007; 17: 1147–51.
34. Bahandari RK, Deem SL, Holliday DK, Jandegian CM, Kassotis CD, Nagel SC, Tillitt DE, vom Saal FS, Rosenfeld CS. Effects of the environmental estrogenic contaminants bisphenol A and 17a-ethinyl estradiol on sexual development and adult behaviors in aquatic wildlife species. Gen Comp Endocrinol 2015; 214: 195-219.
35. Lam SH, Hlaing MM, Zhang X, Yan C, Duan Z, Zhu L, Ung CY, Mathavan S, Ong CN, Gong Z. Toxicogenomic and phenotypic analyses of bisphenol-A early-life exposure toxicity in zebrafish. PLoS ONE 2011; 6: e28273.
36. Shoemaker, CM, Crews D. Analyzing the coordinated gene network underlying temperature-dependent sex determination in reptiles. Semin Cell Dev Biol 2009; 20: 293–303.