Luciano PINOTT, Michele MANONI, Francesca FUMAGALLI, Nicoletta ROVERE, Marco TRETOLA, Antonella BALDI

The role of micronutrients in high-yielding dairy ruminants: Choline and vitamin E

This review addresses the potential role of antioxidants and methyl-group sources in optimising the metabolic health of dairy ruminants. The productivity of high-yielding dairy cows has increased over the past 40 years and the milk yield has doubled. Such increases in milk production have been observed not only in dairy cows but also to some extent in other dairy ruminants such as ewes, goats and buffaloes (Bubalus bubalis). As a consequence, in all specialized dairy ruminants it is essential to optimize the macro and micro-nutrient supply, especially during the most critical period in the animals' production cycle i.e. from parturition until the peak of lactation. In this critical phase, an array of factors can enhance the balance between the intake and demand for nutrients, althoughthe availability and supply of the selected micronutrients is also important. The supplementation of dietary antioxidants or boosting the endogenous methyl group status, via vitamin E, selenium and choline are proposed as possible strategies in maintaining stable metabolichealth and optimising milk production

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1. Abuelo A, Hernández J, Benedito JL, et al (2019): Redoxbiology in transition periods of dairy cattle: Role in the health of periparturient and neonatal animals. Antioxidants, 8, 20.
2. Arshad U, Zenobi MG, Staples CR, et al (2020): Metaanalysis of the effects of supplemental rumen-protected choline during the transition period on performance and health of parous dairy cow. J Dairy Sci, 103, 282-300.
3. Baldi A (2005): Vitamin E in dairycows. Livest Prod Sci, 98, 117-122.
4. Baldi A, Bruckmaier R, D’ambrosio F, et al (2011): Rumen-protected choline supplementation in periparturient dairy goats: effects on liver and mammary gland. J Agric Sci, 150, 1-7.
5. Baldi A, Pinotti L (2006): Choline metabolism in highproducing dairy cows; metabolic and nutritional basis. Can J Anim Sci, 86, 207-212.
6. Baldi A, Pinotti L (2015): Antioxidant nutrition in dairy ruminants. In Book of Abstracts of the 66th Annual Meeting of the European Association for Animal Production, Wageningen Academic Publishers, The Netherlands.
7. Baldi A, Savoini G, Pinotti L, et al (2000): Effect of vitamin E and different energy sources on vitamin E status, milk quality and reproduction in transition cows. J Vet Med A, 47, 599-608.
8. Baldi A, Pinotti L, Giromini C, et al (2018): Nutritional strategies to counteract oxidative stress: benefits and challenges.In Book of abstracts of the 69th Annual Meeting of The European Association for Animal Production. Wageningen Academic Publishers, The Netherlands.
9. Brüsemeister F, Sudekum KH (2006): Rumen-protected choline for dairy cows: the in situ evaluation of a commercial source and literature evaluation of effects on performance and interactions between methionine and choline metabolism. Anim Res, 55, 93-104.
10. Brzezinska-Slebodzinska E, Miller JK, Quigley JD, et al (1994): Antioxidant status of dairy cows supplemented prepartum with vitamin E and selenium. J Dairy Sci, 77, 3087-3905.
11. Campbell MH, Miller JK (1998): Effect of supplemental dietary vitamin E and zinc on reproductive performance of dairy cows and heifers fed excess iron. J Dairy Sci, 81, 2693-2699.
12. Chung YH, Brown NE, Martinez CM, et al (2009): Effects of rumen-protected choline and dry propylene glycol on feed intake and blood parameters for Holstein dairycows in early lactation. J Dairy Sci, 92, 2729–2736.
13. Cooke RF, Silva Del Río N, Caraviello DZ, et al (2007): Supplemental Choline for Prevention and Alleviation of Fatty Liver in Dairy Cattle. J Dairy Sci, 90, 2413-2418.
14. Emmanuel B, Kennelly JJ (1984). Kinetics of methionine and choline and their incorporation into plasma lipids and milk components in lactating goats. J Dairy Sci, 67, 1912- 1918.
15. Garg MR, Sherasia PL, Bhanderi BM (2012): Effect of supplementing bypass fat with and without rumen protected choline chloride on milk yield and serum lipid profile in Jaffarabadi buffaloes. Buffalo Bull, 31, 91-97
16. Hogan JS, Weiss WP, Todhunter DA, et al (1992): Bovine neutrophil responses to parenteral vitamin E. J Dairy Sci, 75, 340- 399.
17. Hogan JS, Weiss WP, Smith KL (1993): Role of vitamin E and selenium in host defence against mastitis. J Dairy Sci,76, 2795-2908.
18. Humer E, Bruggeman G, Zebeli Q (2019): A MetaAnalysis on the Impact of the Supplementation of RumenProtected Choline on the Metabolic Health and Performance of Dairy Cattle. Animals 9, 566.
19. Kankofer M, Lipko J, Zdunczyk S (2005): Total antioxidant capacity of bovine spontaneously released and retained placenta. Pathophysiology, 11, 215-219.
20. Kumar R, Nayak S, Baghel RPS, et al (2017): Effect of Prill Fat and Rumen Protected Choline Supplementation on Feed Intake, Body Weight Changes and Economics of Lactating Murrah Buffaloes. J Anim Res, 7, 355-359.
21. LeBlanc SJ, Herdt TH, Seymour WM, et al (2004): Peripartum serum vitamin e, retinol, and beta-carotene in dairy cattle and their associations with disease. J Dairy Sci,87, 609-619.
22. Lobley GE, Connell A, Revell D (1996): The importance of transmethylation reactions to methionine metabolism in sheep: effect of supplementation with creatine and choline. Brit J Nutr, 75, 1, 47-56.
23. Moyo N, Nielen M, Kruitwagen C, et al (2005): Vitamin E Supplementation and Udder Health: A Meta-Analysis. 159-165.In: H. Hogeveen (Ed), Mastitis in Dairy Production. Current Knowledge and Future Solutions, Wageningen Academic Publishers, Wageningen, The Netherlands.
24. NRC (2001): Nutrient requirements in dairy cattle. Natl. Acad. Press 7th ed., Washington DC.
25. Panda N, Kaur H, Mohanty TK (2005): Reproductive Performance of Dairy Buffaloes Supplemented with Varying Levels of Vitamin E. Asian-Aust. J Anim Sci, 19, 19-25.
26. Piepenbrink MS, Overton TR (2003): Liver metabolism and production of cows fed increasing amounts of rumenprotected choline during the periparturient period. J Dairy Sci, 86, 1722-1733.
27. Pilotto A, Savoini G, Baldi A, et al (2016): Associations between blood fatty acids, β-hydroxybutyrate, and αtocopherol in the periparturient period in dairy cows: An observational study. J Dairy Sci, 99, 8121-8126.
28. Pinotti L (2012): Vitamin-Like Supplementation in Dairy Ruminants: The Case of Choline. 65-86. In: Narongsak Chaiyabutr (Ed), Milk Production - An Up-to-Date Overview of Animal Nutrition, Management and Health, InTech, Narongsak Chaiyabutr, Croatia.
29. Pinotti L, Baldi A, Dell’Orto V (2002): Comparative mammalian choline metabolism with emphasis on the highyielding dairy cow. Nutr. Res. Rev, 15: 315–331.
30. Pinotti L, Baldi A, Politis I, et al (2003): Rumen protected choline administration to transition cows: effects on milk production and Vitamin E status. J Vet Med A, 50, 18-21.
31. Pinotti L, Campagnoli A, Dell’Orto V, et al (2005): Choline: Is there a need in lactating dairy cow, Livest Prod Sci, 98, 149-152.
32. Pinotti L, Campagnoli A, D’Ambrosio F, et al (2008): Rumen-Protected Choline and Vitamin E Supplementation in Periparturient Dairy Goats: Effects on Milk Production and Folate, Vitamin B12 and Vitamin E Status. Animal, 2, 1019-1027.
33. Politis I, Hidiroglou N, Batra TR, et al (1995): Effects of Vitamin E on Immune Function of Dairy Cows. Am J Vet Res, 56, 179-184.
34. Politis I (2012): Reevaluation of vitamin E supplementation of dairy cows: Bioavailability, animal health and milk quality. Animal, 6, 1427–1434
35. Preynat A, Lapierre H, Thivierge MC, et al (2009). Effects of supplements of folic acid, vitamin B12, and rumen-protected methionine on whole body metabolism of methionine and glucose in lactating dairy cows. J Dairy Sci, 92, 677-689.
36. Rebucci R, Pinotti L, Fusi E, et al (2013). Role of Choline and Methionine in Bovine Mammary Epithelial Cell Line Exposed to Hydrogen Peroxide. J Nutr Ecol Food Res, 1, 189-193.
37. Sales J, Homolka P, Koukolová V (2010): Effect of dietary rumen-protected choline on milk production of dairy cows: A meta-analysis. J Dairy Sci, 93, 3746-3754.
38. Smith KL, Harrison JH, Hancock DD, et al (1984): Effect of Vitamin E and Selenium Supplementation on Incidence of Clinical Mastitis and Duration of Clinical Symptoms. J Dairy Sci, 67, 1293-1300.
39. Tsiplakou E, Mavrommatis A, Kalogeropoulos T, et al (2017): The effect of dietary supplementation with rumenprotected methionine alone or in combination with rumenprotected choline and betaine on sheep milk and antioxidant capacity. J Anim Physiol Anim Nutr, 101, 1004-1013.
40. Toker NY (2007): Blood serum Vitamin A and E concentrationsand distribution into lipoprotein fractionsof pregnant sheep and newborn lambs. Revue Méd Vét, 158, 413-417.
41. Vagni S, Saccone F, Pinotti L, et al (2011): Vitamin E Bioavailability: Past and Present Insights. Food Nutr Sci, 2, 1088-1096.
42. Weiss WP, Hogan JS, Todhunter DA, et al (1997): Effect of Vitamin E Supplementation in Diets with a Low Concentration of Selenium on Mammary Gland Health of Dairy Cows. J Dairy Sci, 80, 1728-1737.
43. Weiss WP (1998): Requirements of Fat-Soluble Vitamins for Dairy Cows: A Review. J Dairy Sci, 81, 2493-2501.
44. Zenobi MG, Scheffler TL, Zuniga JE, et al (2018): Feeding increasing amounts of ruminally protected choline decreased fatty liver in nonlactating, pregnant Holstein cows in negative energy status. J Dairy Sci, 101, 5902– 5923.