Ayşe TOPAL, Göksen ÇEÇEN, O.Sacit GORGÜL, Semra AKGÖZ

The cardiopulmonary effects of sevoflurane, isoflurane and halothane anesthesia during spontaneous or controlled ventilation in dogs

Bu çalışma ile köpeklerde spontan ventilasyon (SV) ve kontrollü ventilasyon (CV) sırasında sevofluran (SEV), izofluran (ISO) ve halothan (HAL) anestezilerinin kardiyopulmoner etkilerinin incelenmesi amaçlandı. Çalışma deneysel olarak planlandı ve çalışmada 60 sağlıklı melez köpek kullanıldı. Köpekler eşit olacak şekilde rastgele 6 anestezi grubuna ayrıldı: SEV/SV; SEV/CV; ISO/SV; ISO/CV; HAL/SV; HAL/CV. Xylazine HCL ile premedikasyonu takiben indüksiyon thiopental sodium ile yapıldı ve SEV, ISO ve HAL ile 90 dakika boyunca inhalasyon anestezisi oluşturuldu. Kardiyopulmoner parametreler [kalp frekansı (HR), solunum sayısı (RR), ortalama arteriyel kan basıncı (MAP), solunum sonu karbondioksit düzeyi (ETCO2), oksijen saturasyonu (SpO2), sentral venöz basınç (CVP), beden ısısı, parsiyel arteriyel oksijen basıncı (PaO2), parsiyel arteriyel karbondioksit basıncı (PaCO2) ve arteriyel pH] ölçüldü. İlk ölçüm değeri, inhalasyon anestezikleri ile bilincin kaybolmasından bir dakika sonra, diğer ölçüm değerleri ise 15., 30., 45. 60. ve 90. dakikalarda kaydedildi. HR’de anestezik maddeler arasında SV ve CV sırasında belirgin bir farklılık kaydedilmedi. SV’de ISO ve HAL anestezileri ile RR anlamlı şekilde azaldı (p

Köpeklerde sevofluran, izofluran ve halotan anestezilerinin spontan ve kontrollü ventilasyon sırasındaki kardiyopulmoner etkileri

The objective of this study was to investigate the cardiopulmonary effects of sevoflurane (SEV), isoflurane (ISO) and halothane (HAL) anesthesia during spontaneous ventilation (SV) or controlled ventilation (CV) in dogs. An experimental study was designed. Sixty healthy cross breed dogs were used for the study. Dogs were randomly allocated to six anesthesia groups (n = 10 in each group): SEV/SV; SEV/CV; ISO/SV; ISO/CV; HAL/SV; HAL/CV. After premedication with xylazine HCl, anesthesia was induced with thiopental sodium. Inhalation anesthesia was maintained for 90 minutes with SEV, ISO, or HAL. Cardiopulmonary parameters [heart rate (HR), respiratory rate (RR), mean arterial blood pressure (MAP), end tidal carbon dioxide level (ETCO2), oxygen saturation (SpO2), central venous pressure (CVP), body temperature, arterial partial pressure of oxygen (PaO2), arterial partial pressure of carbon dioxide (PaCO2), and arterial pH] were measured after induction of anesthesia; the first measurement was taken one minute after the loss of consciousness with SEV, ISO, or HAL and the others were done at 15th, 30th, 45th, 60th and 90th minutes. There was not any significant difference in HR between anesthetics among SV and CV. RR decreased significantly during ISO and HAL anesthesia in SV (p

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1. Apaydın N, Koç B (2005): Köpeklerde Isoflurane ve Sevoflurane Anestezisinin Hemodinamik ve Biyokimyasal Parametrelere Olan Etkilerinin Karsılastırılması, Vet Cer Derg, 11, 31-35.
2. Bednarski RM (1996): Anesthesia and immobilization of specific species. Dogs and cats. 593. In: JC Thurmon, WJ Tranquilli and GJ Benson (Eds) Lumb and Jones’ Veterinary Anesthesia, 3rd ed. Williams & Wilkins, Baltimore.
3. Bernard JM, Wouters PF, Doursout MF, Florence B, Chelly JE, Merin RG (1990): Effects of sevoflurane and isoflurane on cardiac and coronary dynamics in chronically instrumented dogs. Anesthesiology, 72, 659-662.
4. Cullen DJ, Eger E III (1974): Cardiovascular effects of carbon dioxide in man. Anesthesiology, 41, 345.
5. Ebert TJ, Harkin CP, Muzi M (1995): Cardiovascular responses to sevoflurane: a review. Anesth Analg, 81, 11-22.
6. Fourcade HE, Stevens WC, Larson CP, Cromwell TH, Bahlman SH, Hickey RF, Halsey MJ, Eger EIII (1971): The ventilatory effects of forane, a new inhaled anesthetic. Anesthesiology, 35, 26-31.
7. Frink EJ, Morgan SE, Coetzee A, Conzen P, Brown BJ (1992): The effects of sevoflurane, halothane, enflurane and isoflurane on hepatic blood flow and oxygenation in chronically instrumented greyhound dogs. Anesthesiology, 76, 85- 90.
8. Gorgul OS (1998): Anestezi. 532-536. In: Imren (Ed), Kedi ve köpek hastalıkları, 1.baskı. Medisan yayın serisi no: 32, Ankara
9. Green WB (1995): The ventilatory effects of sevoflurane. Anesth Analg, 81, 23-26.
10. Hall LW, Clarke KW, Trim CM (2001): Anaesthesia of the dog. 385-439. In: LW Hall, KW Clarke, CM Trim (Eds), Veterinary Anaesthesia, 10th ed. W.B. Saunders, London.
11. Haskins SC (1999): Perioperative monitoring. 123-146. In: RR Paddleford (Ed), Manual of Small Animal Anesthesia, 2nd ed. W. B. Saunders Co, Philadelphia.
12. Kaplan PM (1992): Monitoring. 21-37. In: RJ Murtaugh, PM Kaplan (Eds), Veterinary Emergency and Critical Care Medicine. Mosby Year Book, St. Louis.
13. King LG, Hendricks JC (1994): Use of positive-pressure ventilation in dogs and cats: 41 cases (1990–1992). J Am Vet Med Assoc, 204, 1045–1052.
14. Klide AM, Calderwood HW, Soma LR (1975): Cardiopulmonary effects of xylazine in dogs. Am J Vet Res, 36, 931-935.
15. Koç B, Sarıtaş KZ (2004): Genel anestezi, 85-104. In: Veteriner Anesteziyoloji ve Reanimasyon. Medipres Matbaacılık, Malatya.
16. Machon RG, Raffe MR, Robinson EP (1995): Central venous pressure measurements in the caudal vena cava of sedated cat. J Vet Emerg Crit Care, 5, 121-129.
17. Mc Donell W (1996): Respiratory system. 115-147. In: JC Thurmon, WJ Tranquilli, GJ Benson (eds), Lumb and Jones’ Veterinary Anesthesia, 3rd ed. Williams & Wilkins, Baltimore.
18. Merin RG, Bernard JM, Doursout MF, Cohen M, Chelly JE (1991): Comparison of the effects of isoflurane and desflurane on cardiovascular dynamics and regional blood flow in the chronically instrumented dog. Anesthesiology, 74, 568-574.
19. Muir WW, Hubbell JAE, Skarda R (1995): Handbook of Veterinary Anesthesia, 209-219. In: WW Muir, JAE Hubbell (Eds) 2nd ed. Mosby-Year Book, St.Louis.
20. Muir WW (1998a): Anesthesia for dogs and cats with cardiovascular disease – Part I. Compend Cont Educ Pract Vet, 20, 78-87.
21. Muir WW (1998b): Anesthesia for dogs and cats with cardiovascular disease – Part II. Compend Cont Educ Pract Vet, 20, 473-484.
22. Mutoh T, Nishimura R, Kim HY, Matsunaga S, Kadosawa T, Mochizuki M, Sasaki N (1995): Rapid inhalation induction of anesthesia by halothane, enflurane, isoflurane and sevoflurane and their cardiopulmonary effects in dogs. J Vet Med Sci, 57, 1007-1013.
23. Mutoh T, Nishimura R, Kim HY, Matsunaga S, Sasaki N (1997): Cardiopulmomary effects of sevoflurane, compared with halothane, enflurane and isoflurane, in dogs. Am J Vet Res, 58, 885-890.
24. Nakaigawa Y, Akazawa S, Shimizu R, Ishii R, Yamato R (1995): Comparison of the effects of halothane, isoflurane, and sevoflurane on atrioventricular conduction times in pentobarbital-anesthetized dogs. Anesth Analg, 81, 249-253.
25. Nicholson A, Watson ADJ (2001): Survey of small animal anaesthesia. Aust Vet J, 79, 613-619.
26. Oliva VNLS, Aguiar AJA, Eugênio FR, Andrade AL, Guimaraes CRCB, Perri SHV (2002): Sevoflurane or halothane anaesthesia after propofol or thiopentone induction for orthopedic surgery in dogs. Vet Anaesth Analg, 1, 75-79.
27. Pagel PS, Kampine JP, Schmeling WT (1991): Comparison of the systemic and coronary hemodynamic actions of desflurane, isoflurane, halothane, and enflurane in the chronically instrumented dog. Anesthesiology, 74, 539-551.
28. Perel A, Pizov R (1992): Cardiovascular effects of mechanical ventilation. 51-65. In: A Perel, MC Stock (Eds), Mechanical Ventilatory Support. Williams & Wilkins, Baltimore.
29. Polish I, Gasthuys F, Laevens H, Van Ham L, De Rick A (2001): The influence of ventilation mode (spontaneous ventilation, IPPV and PEEP) on cardiopulmonary parameters in sevoflurane anaesthetized dogs, J Am Vet Med Assoc, 48, 619-630.
30. Short CE (1987): Inhalant anesthetics. 70 -90. In: Principles & Practice of Veterinary Anesthesia. Williams & Wilkins, Baltimore.
31. Steffey EP, Howland DJR (1977): Isoflurane potency in the dog and cat. Am J Vet Res, 38, 1833-1836.
32. Steffey EP (1996): Inhalation anesthetics. 297-329. In: JC Thurmon, WJ Tranquilli, GJ Benson (Eds), Lumb and Jones’ Veterinary Anesthesia, 3rd ed. Williams & Wilkins, Baltimore.
33. Tacke S, Xiong, Schimke E (2000): Sevoflurane anaesthesia in dogs after premedication with L-methadone, diazepam and propofol in comparison to halothane and isoflurane, in Proceedings. 7th World Congress of Veterinary Anaesthesia Berne Sept. 20-23:79.
34. Thurmon JC, Tranquilli WJ, Benson GJ (1996b): Injectable anesthetics. 210-225. In: JC Thurmon, WJ Tranquilli, GJ Benson (Eds) Lumb and Jones’ Veterinary Anesthesia, 3rd ed. Williams & Wilkins, Baltimore.
35. Topal A (2001): Anestezik ilaçlar ve anestezi teknikleri. 36-60. In: Veteriner Anesteziyoloji ve Reanimasyon Ders Notu, Uludag Üniversitesi Veteriner Fakültesi yayınları No:1, Bursa.
36. Topal A (2005) İnhalasyon anesteziklerinin özellikleri ve inhalasyon anestezikleri, 131-148. In: Veteriner Anestezi, Nobel & Güneş Tıp Kitapevi, Bursa.
37. Wallin RF, Regan BM, Napoli MD, Stern IJ (1975): Sevoflurane: A new inhalational anesthetic agent, Anesth Analg, 54, 758-766.
38. Wright B, Hellyer WP (1996): Pulse oximetry and capnography, Respiratory monitoring during anesthesia, Compend Cont Educ Pract Vet, 18, 1083-1097.