Mustafa Yavuz GULBAHAR, Cenk YARDIMCI, Yonca Betil KABAK, Semra Okur GUMUSOVA

Myxoid liposarcoma in a cat

Bu çalışmada, 15 yaşlı erkek bir kedinin sol humerusunun proksimal bölgesindeki miksoid liposarkom tanımlanmıştır. Skapula ile birlikte sol kol ampute edildi. Tümörün kesit yüzü krem- beyaz renkte, müköz yapı yanında hemorajik ve nekrotik odaklar içeren yumuşak loplu bir yapıdaydı. Mikroskobik olarak tümör, yuvarlak– polygonal hücreler içeriyordu. Hücreler çok sayıda yuvarlak, değişik büyüklüklerde, belirgin intrasitoplazmik vakullere sahipti. Oil Red O boyası ile tümör hücrelerinin sitoplazmik vakuollerindeki yağ damlacıkları gösterildi. Müsini akla getiren ekstrasellüler miksoid yapı Alcian blue boyası ile boyandı. Tümör hücreleri vimentin pozitif fakat pansitokeratin ve S-100 negatifti. Örneklerde polimeraz zincir reaksiyonu (PZR) ile feline leukemia virus (FeLV), feline sarcomavirus (FeSV) veya feline immunodeficiency virus (FIV) deoksiribonükleik asit (DNA)’leri görülemedi. Bu vaka, kedilerdeki miksoid liposarkomu tanımlayan ilk raporudur.

Bir kedide miksoid liposarkom

In the study, a myxoid liposarcoma in the proximal region of the left humerus of a 15-year-old male, shorthair cat was described. Left arm along with scapula was amputated. The cut section of tumor was tan to white with soft multilobulated mass which contained hemorrhagic and necrotic foci as well as mucuous composition. Microscopically, the tumor was composed of roundto- polygonal cells. The cells had numerous round, variable-sized, well-defined, intracytoplasmic vacuoles. The lipid droplets in the cytoplasmic vacuoles of the tumor cells was showed with Oil Red O staining. A myxoid extracellular substance remind of mucin was stained by Alcian blue staining (pH = 2,5). Tumor cells were strongly positive for vimentin, but negative for pancytokeratin and S- 100. A polymerase chain reaction (PCR) assay from samples showed no evidence of feline leukemia virus (FeLV) / feline sarcomavirus (FeSV) or feline immunodeficiency virus (FIV) deoksiribonucleic acid (DNA). This case describes a first report of myxoid liposarcoma in a cat.

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