Hatice ERDOST, Şerife TÜTÜNCÜ, Nesrin ÖZFİLİZ

Immunohistochemical distribution of ghrelin positive cells in the abomasum of sheep

Ghrelin rat ve insan midesinden izole edilen 28 amino asitli bir peptiddir. Bu peptid öncelikle mide tarafındanüretilmektedir, ayrıca ince ve kalın barsaklardan, pankreas, hipofiz, böbrek, plasenta, immun sistem, testis, ovaryum vehipotalamusun arkuat nukleusundan küçük miktarlarda elde edilmiştir. Çalışmamızda, koyun abomasumunda Ghrelin immun pozitifhücrelerin dağılımı incelendi. Abomasum cardia, fundus, proksimal ve distal pilorus olmak üzere 4 bölüme ayrılarak incelendi.Sonuç olarak, Ghrelin immunpozitif hücrelerin diğer memeli hayvanlarda olduğu gibi abomasumun mukozal katmanına dağıldığıgörüldü.

Koyun abomasumunda ghrelin pozitif hücrelerin immunohistokimyasal dağılımı

Ghrelin is a novel 28-amino-acid-peptide isolated from the rat and human stomach. This peptide is predominantlyproduced by the stomach, in addition lower amounts derive from small and large intestines, pancreas, pituitary gland, kidney,placenta, immun system organs and cells, testis, ovary and arcuate nucleus of hypothalamus. In this study, distrubition of ghrelinimmunoreactive cells in the abomasum of sheep was investigated. Tissue samples were taken from cardia, fundus , the proximalregion of pylorus, main/distal pylorus regions of abomasum. The results have revealed that ghrelin immunopositive cells distrubutedthroughout the mucosal layer of abomasum of sheep, in other mammalian species.

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