Cenk YARDIMCI, Ahmet ÖZAK, İlkay Koray BAYRAK, Özlem H. NİSBET, Cevat NİSBET

Evaluation of the effect of platelet rich plasma (PRP) on enhancement of bone healing in diaphyseal bone defects by radiography and computed tomography

Bu çalışmada; trombositten zengin plazmanın (PRP), otojen kansellöz greftler ile birlikte diyafizer defektlerde kemik rejenerasyonuna olan etkisi değerlendirildi. Yirmi tavşanda tibianın orta 1/3 diyafizinde 4 mm. genişliğinde defekt oluşturuldu. Tavşanlar, her birinde 10 tavşan içeren iki gruba ayrıldı, birinci gruptaki tavşanlara sadece otojenöz kansellöz greft, ikinci gruptakilere PRP ile birlikte otojenöz kansellöz greft yerleştirildi. Operasyon sonrası 0., 15., 30., 60. ve 90. günlerde radyografi ve bilgisayarlı tomografi (BT) çekimleri yapıldı ve değerlendirildi. Kemik oluşumu, kaynama ve yeniden şekillenme derecelendirmesine göre 30., 60. ve 90. günlerde birinci grupta, ikinci gruba göre daha iyi sonuçlar elde edildi. Birinci grupta dansite, 60. günde 0., 15. ve 30. güne göre daha belirgin bir artış gösterdi. Sonuç olarak; PRP, otojenöz kansellöz greftler ile birlikte diyafizer kemik defektlerine uygulandığında, kemik rejenerasyonunu artırıcı hiçbir katkısı olmadığı anlaşıldı.

Diyafizeal kemik defektlerinde trombositten zengin plazmanın (PRP) kemik iyileşmesini artırma üzerindeki etkisinin radyografi ve bilgisayarlı tomografi ile değerlendirilmesi

The effect of platelet-rich plasma (PRP) with autogenous cancellous bone graft on enhancement of bone healing in diaphyseal bone defects was evaluated. A 4-mm defect was created in the middiaphysis of the tibias of 20 rabbits. Rabbits were divided into two groups of ten animals each: only autogenous cancellous graft, PRP and autogenous cancellous graft. In animals of group 1, only autogenous cancellous grafts, and to those in group 2, PRP and autogenous cancellous grafts, were applied to the defect. Radiographical and computed tomography (CT) views were taken and evaluated on postoperative days 0, 15, 30, 60, and 90. According to the bone formation, union, and remodeling scores, group 1 had better scores than group 2 on days 30, 60, and 90. The density was significantly increased on day 60 than on days 0, 15, and 30 in group 1. In conclusion, it was evaluated that PRP could not enhance the bone regeneration in diaphyseal defects when used with autogenous cancellous bone graft.

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