Sinan KANDIR, Ercan KESKİN

Effects of hypothyroidism and hyperthyroidism on hematological parameters in rats

Bu çalışmada, hipotiroidizm ve hipertiroidizmin ratların hematolojik parametreleri üzerine etkilerini yorumlamak amaçlanmıştır. Toplam 42 adet erkek Wistar rat, ötiroid, hipotiroid ve hipertiroid olarak 3 eşit gruba ayrıldı. Hipotiroidizm ve hipertiroidizm sırasıyla 6-n-propil-2-tiourasil (PTU; % 0,05, w/v) ve L-tiroksin (T4; % 0,0012, w/v) içme sularına katılarak gerçekleştirildi. Hematolojik parametrelerin ve serum hormon profillerinin belirlenmesi için her grupta 7 rattan, 3. ve 6. haftanın sonunda kan örnekleri toplandı. Üçüncü hafta grupları arasında, yalnızca hipotiroid grubunun monosit yüzdesi ötiroid grubuna kıyasla arttı (p

Ratlarda hipotiroidizm ve hipertiroidizmin hematolojik parametreler üzerine etkileri

In this study, it was aimed to interpret the effects of hypothyroidism and hyperthyroidism on hematological parameters in rats. A total of 42 male Wistar rats were divided into 3 equally groups as euthyroid, hypothyroid, hyperthyroid. Hypothyroidism and hyperthyroidism were induced by 6-n-propyl-2-thiouracil (PTU; 0,05%, w/v) and L-thyroxine (L-T4; 0,0012%, w/v) received in drinking water, respectively. Blood samples were withdrawn from 7 rats of each group at the end of 3rd and 6th weeks for determination of the hematological parameters and serum hormone profiles. Among the 3rd week groups only percentage of monocyte was increased (p

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