Sedat SAKALLI, Veysel Özgür BARIŞ, Ahmet BÜYÜK, Fatih POYRAZ, Murat Can GÜNEY

Takılabilir Kardiyoverter Defibrilatör ile Tedavi Edilen Kalp Yetersizliği Hastalarında Mortaliteyi Belirleyen Laboratuvar Paramaterleri: Tek Merkezli, Uzun Dönemli Sonuçlar

Amaç: Nötrofil/lenfosit oranı (NLR), Monosit/HDL oranı (MHR), lenfosit/monosit oranı (LMR) ve platelet/lenfosit oranı (PLR) kardiyovasküler hastalıklarda prognostik değerleri kanıtlanmış olan enflamasyon belirteçleridir. Fakat bu belirteçlerin takılabilir kardiyoverter defibrillator (ICD) ile tedavi edilen kalp yetersizliği hastalarında prognostik değerini gösteren klinik çalışma henüz mevcut değildir. Bu çalışmada NLR, MHR, LMR, PLR oranları ile ICD’si olan kalp yetersizliği hastalarında mortalite gelişimi arasındaki ilişkinin gösterilmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmaya, Ocak 2015-Aralık 2019 tarihleri arasında sistolik kalp yetersizliği nedeniyle ICD implantasyonu yapılmış 194 hasta dahil edildi. Bulgular: Hastaların ortalama yaşı 59,84±13,26 idi. Kadın cinsiyet oranı %25,3 idi. Medyan 27 aylık izlem sonrasında 16 hastada ölüm gelişti (%8). Exitus gelişen grupta bazal üre, ürik asit, gama-glutamil transferaz, C-reaktif protein, nötrofil düzeyleri yüksek saptanırken; hemoglobin ve lenfosit düzeyleri ise düşük saptandı. Takiplerde ölüm gelişen grupta NLR, MHR ve PLR oranları istatistiksel olarak anlamlı şekilde yüksek saptanırken (p=0,001, p=0,049, p=0,020, sırasıyla) LMR belirgin derecede düşük saptanmıştır (p

Laboratory Parameters Predicting Mortality in Heart Failure Patients treated with Implantable Cardioverter Defibrillator: Single Centre, Long-term Results

Objectives: Neutrophil/lymphocyte (NLR), Monocyte/HDL (MHR), lymphocyte/monocyte (LMR) and platelet/lymphocyte ratios (PLR) are inflammation markers with proven prognostic values in various cardiovascular diseases. However, a clinical study demonstrating the prognostic value of these markers in heart failure (HF) patients treated with an implantable cardioverter-defibrillator (ICD) is not yet available. It is aimed to demonstrate the relationship between NLR, MHR, LMR, PLR and mortality development in patients with HF with ICD. Materials and Methods: One hundred and ninety-four patients who underwent ICD implantation due to systolic HF between January 2015 and December 2019 were included in the study. Results: The mean age was 59.84±13.26 years. The female gender ratio was 25.3%. Death developed in 16 patients (8%) after a median follow-up of 27 months. While basal urea, uric acid, gamma-glutamyl transferase, C-reactive protein and neutrophil levels were found to be high, hemoglobin and lymphocyte levels were found to be low in the exitus developing group. While the rates of NLR, MHR and PLR were statistically significantly higher in the group with death during follow-up (p=0.001, p=0.049, p=0.020, respectively ), LMR was significantly lower (p

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