Recep ÇETİN, Alper ÇELİK, Işın PAK, Abdullah ÇETİN

Subungual epidermoid carcinoma

Tırnak altında lokalize epidermoid karsinom tırnak yatağı tümörlerinin oldukça nadir görülen bir alt tipidir ve infeksiyöz hastalıkları taklit edebilir. Tırnak altının pleomorfik fibroma, kondroma, glomus tümörü, perinörinoma ve melanoma gibi değişik histolojik alt tipleri bildirilmiştir (1-5). Günümüze kadar sadece 12 subungual yassı hücreli karsinom olgusu bildirilmiştir (6-17). Bu bildiride paronişi tanısı ile tedavi edilerek tanı ve tedavide gecikmeye neden olunmuş bir subungual invaziv epidermoid karsinom olgusu sunulmuştur. Olgu sunumu için hastadan sözel onay alınmıştır.

Subungual epidermoid karsinom

Epidermoid carcinoma of the subungual area is a rare variant of the tumours of the nail bed, and may mimic infectious diseases. Different histological variants of subungual tumours including pleomorphic fibroma, chondroma, glomus tumour, perineurinoma, and melanoma have been reported (1-5). Only 12 cases of subungual squamous carcinoma have been reported to date (6-17). We hereby present a case of subungual invasive epidermoid carcinoma that has previously been treated as paronychia leading to a delay in diagnosis and treatment. Patient's informed consent has been taken for this case report.

PDF

___

1. Hsieh YJ, Lin YC, Wu YH et al.Subungual pleomorphic fi broma. J Cutan Pathol. 2003;30:569-571.
2. Bostanci S, Ekmekci P, Ekinci C et al. Subungual osteochondroma: a case report. Dermatol Surg. 2001;27:591-593.
3. Tomak Y, Akcay I, Dabak N et al. Subungual glomus tumours of the hand: diagnosis and treatment of 14 cases. Scand J Plast Reconstr Surg Hand Surg. 2003;37:121-124.
4. Baran R, Perrin C. Subungual perineurioma: a peculiar location. Br J Dermatol. 2002;146:125-128.
5. O’Leary JA, Berend KR, Johnson JL et al. Subungual melanoma. Review of 93 cases with identifi cation of prognostic variables. Clin Orthop. 2000;(378):206-212
6. Shapiro L, Baraf CS. Subungual epidermoid cancer and keratoacanthoma. Cancer 1970;25:141-152.
7. Mikhail GR. Subungual epidermoid carcinoma. J Am Acad Dermatol 1984;11:291-298.
8. Fleckman P, Bernstein G, Barker E. squamous cell carcinoma of the nail bed treated as chronic paronychia and wart for fourteen years. Cutis 1985;36:189-191.
9. Shelley ED, Shelley WB. Exploratory nail plate removal as a diagnostic aid in painful subungual tumours: glomus tumour, neurofibroma, and squamous cell carcinoma. Cutis 1986;38:310-312
10. Hale LR, Dawber RPR. Subungual squamous cell carcinoma presenting with minimal nail changes: a factor in delayed prognosis? Aust J Dermatol 1998;39:86-88.
11. Betti R, Vergani R, Inselvini E et al. Guess what! Subungual squamous cell carcinoma mimicking chronic paronychia. Eur J Dermatol. 2000;10:149-150.
12. Yip KM, Lam SL, Shee BW et al. Subungual squamous cell carcinoma: report of 2 cases. J Formos Med Assoc. 2000;99:646-49.
13. Ryu JS, Cho JW, Moon TH et al. Squamous cell lung cancer with solitary subungual metastasis. Yonsei Med J. 2000;41:666-668.
14. Obiamiwe PE. Subungual squamous cell carcinoma. Br J Plast Surg. 2001;54:631-632.
15. Dobson CM, Azurdia RM, King CM. Squamous cell carcinoma arising in a psoriatic nail bed: case report with discussion of diagnostic diffi culties and therapeutic options. Br J Dermatol. 2002;147:144-149.
16. Yaparpalvi R, Mahadevia PS, Gorla GR et al. Radiation therapy for the salvage of unresectable subungual squamous cell carcinoma. Dermatol Surg. 2003;29:294-296.
17. Dominguez-Cherit J, Garcia C, Vega-Memije ME et al. Pseudofi brokeratoma: an unusual presentation of subungual squamous cell carcinoma in a young girl. Dermatol Surg. 2003;29:788-789.
18. Linares MD, Hardisson D, Perna C. Subungual malignant melanoma of the hand: unusual clinical presentation. Scand J Plast Reconstr Surg Hand Surg 1998;32:347-350