Preparation and in vitro evaluation of sustained release suppositories of indomethacine

Indometazinin sürekli etkili suppozituvarları suda çözünmeyen taşıyıcı olan selüloz asetat ftalat (ÇAP) ve Eudragit RL/RS kullanılarak hazırlandı. Witepsol H15 ve polietüen glikol (PEG) karışımları hidrofobik ve hidrofilik sıvağlar olarak seçildi. Formülasyonlar üzerinde dağılma zamanı, sertlik ve salım deneyleri yapıldı. Sonuçlar matriks materyali olarak Eudragit RL/RS (1:1) karışımının ÇAP'tan daha uygun olduğunu gösterdi. Salım deneylerinin kinetik değerlendirilmesinde en iyi uyum Q$sqrt{t}$ kinetiği ile elde edildi.

Indometazinin sürekli etkili suppozituvarlarının hazırlanması ve in vitro değerlendirilmesi

Indomethacin (IM) sustained release suppositories were prepared by using a solid matrix of cellulose acetate phythalate (CAP) and trimethylamonium methacrylate chloride's (Eudragit RL and RS) as poorly soluble carters. Witepsol HIS and polyethylene glycol (PEG) mixtures were used as examples of hydrophobic and hydrophilic bases, respectively. Disintegration time, fracture point and release experiments were conducted on the formulations. The results indicate that Eudragit RL/RS (1:1) combination was found more suitable than CAP as a matrix material. From the kinetic assesment of release data, the best fit was achieved with Q$sqrt{t}$ kinetic.

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