MICROEMULSIONS

Son yıllarda mevcut etken maddelerin etkisini artıracak yeni dozaj formlarının tasarımına önem verilmeye başlanmıştır. Bu yaklaşımın yararı, sadece etken maddenin terapötik etkisinin artırılması değil, aynı zamanda gerekli total dozun azaltılmasını ve toksik yan etkilerin minimuma indirilmesini sağlamasıdır. Bu konudaki çalışmaların bir kısmı da mikroemülsiyonlar üzerinde yoğunlaşmaktadır. Bu makalede mikroemülsiyonların tanımı, özellikleri, avantajları, hazırlanma yöntemleri, bazı uygulama alanları ve bu konuda son yıllarda yapılan araştırmalar özetlenmiştir

MİKROEMÜLSİYONLAR

During the past few years, much attention has been given to the design of new dosage forms that increase the effectiveness of existing drugs. The use of this approach has the potential not only to improve the therapeutic efficacy of a drug but also to allow a reduction in the total dose needed, minimizing toxic side effects. Some of this activity has focused on the development of microemulsions. The present article provides a general overview of definition, properties, advantages, preparations, some application areas and recent researches on microemulsions

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  • 1. Benita, S., "Microemulsions", Garti and Aserin, (Eds.) Microencapsulation Methods and Industrial Applications, Marcel Dekker, Inc., New York p. 501-519 (1996)
  • 2. Rosano, H., Cavallo, J.L., Chang, L.D., Whittam, J.H., "Microemulsions: A commentary on their preparation", J. Soc. Cosmet. Chem., 39, 201-209 (May/June 1988)
  • 3. Bhargava, H.N., Narurkar, A., Lieb, L.M., "Using microemulsions for drug delivery", Pharm. Technol, 46, 1-5 (March 1987)
  • 4. Rosano, H., "Microemulsions", J.Soc. Cosmet. Chem., 25, 609-619 (November 1974)
  • 5. Prince, L.M., "Microemulsions", J.Soc.Cosmet. Chem., 21, 193-204 (Mar.4, 1970)
  • 6. Prince, L.M., "Microemulsions" Emulsions and Emulsion Technology, Marcel Dekker Inc., New York, p. 127-175 (1983)
  • 7. Osborne, D.W., Ward, A.J., O'Neill, K.J., "Microemulsions as topical drug delivery vehicles: in-vitro transdermal studies of a model hydrophilic drug", J.Pharm. Pharmacol, 43, 451-454 (1990)
  • 8. Trotta, M., Gasco, M.R., Morel, S., "Release of drugs from oil - water microemulsions", J. Controlled Release, 10237-243 (1989)
  • 9. Primorac, M., Stupar, M., Vuleta, G., Vasiljeviç, D., "Rheological properties of oil - water microemulsions" Pharmazie, 47 (H.8), 645-646 (1992)
  • 10. Kale, N.J., Loyd, V.A., "Studies on microemulsions using Brij 96 as surfactant and glycerin, ethylene glycol and propylene glycol as cosurfactants", Int. J.Pharm., 57, 87-93 (1989)
  • 11. Jachowicz, J., Berthiaume, M.D., "Microemulsions vs. Macroemulsions in hair care products", Cosmetics and Toiletries, 108, 65-72 (March 1993)
  • 12. Chunhee, K.S., Wade, W.H., "Optimal surfactant structures for cosurfactant-free microemulsion systems I C16 and C14 guerbet alcohol hydrophobes", J.Disper. Sci. Technol, 13 (5), 491-514 (1992)
  • 13. Biais, J., Bothorel, B., Lalanne, P., "Microemulsion model experimental and theoretical diagrams in influence of bending energy", J.Disper. Sci.Technol, 12(5-6) 417-441 (1991)
  • 14. Panayiotis, P.C., Seang H.Y., "Particle size determination of phase-inverted water - in -oil microemulsions under different dilution and conditions", Int. J. Pharm., 115, 225-234 (1995)
  • 15. Attwood, D., Mallon, C, Taylor, C.J., "Phase studies on oil - in - water phospholipid microemulsions", Int. J.Pharm., 84, R5-R8 (1992)
  • 16. Trotta, M., Fubini, B., Gallarate, M., Gasco, M.R., "Calorimetric study on the solubilization of butanol by alkylphosphate and alkylphosphate-lecithin systems", J.Pharm.Pharmacol, 45, 993-995 (1993)
  • 17. Gasco, M.R., Carlotti, M.E., Trotta, M., "In vitro release of propranolol from oil/water microemulsions", Int.J.Cosmet. Sci, 10, 263-269(1988)
  • 18. Pattarino, F., Marengo, E., Gasco, M.R., Carpignano, R., "Experimental design and partial least squares in the study of complex mixtures: microemulsions as drug carriers", Int. J.Pharm., 91, 157-165 (1993)
  • 19. Aboofazeli, R., Lawrence, M.J., "Investigations into the formation and characterization of phospholipid microemulsions. I.Pseudo-ternary phase diagrams of systems containing water -lecithin - alcohol - isopropyl miristate", Int. J.Pharm., 93, 161-175 (1993)
  • 20. Carlfors, J., Blute, I., Schmidt, V., "Lidocaine in microemulsion - a dermal delivery system", J.Disper. Sci. Technol, 12 (5-6), 467-482 (1991)
  • 21. Boberger, L., Larsson, K., "A study of fat oxidation in a microemulsion system" J.Disper. Sci.Technol, 8 (3) 207-215 (1987)
  • 22. Fevrier, F., Bobin, M.F., Lafforgue, C, Martini, M.C., "Advances in microemulsions and transepidermal penetration of tyrosine", S.T.P Pharma Sci, 1 (1), 60-63 (1991)
  • 23. Aboofazeli, R., Lawrence, C.B., Wicks, S.R., Lawrence, M.J., "Investigations into the formation and characterization of phospholipid microemulsions III.Pseudo-ternary phase diagrams of systems containing water-lecithin-isopropyl miristate and either an alkonoic acid, amine, alkanediol, polyethylene glycol alkyl ether or alcohol as cosurfactant" Int. J.Pharm., 111, 63-72 (1994)
  • 24. Aboofazeli, R., Lawrence, M.J., "Investigations into the formation and characterization of phospolipid microemulsions II.Pseudo ternary phase diagrams of systems containing water -lecithin - isopropyl myristate and alcohol: Influence of purity of lecithin", Int. J.Pharm., 106, 51-61(1994)
  • 25. Primorac, M., Dakovic, L.J., Stupar, M., Vasiljeviç. D., "The influence of temperature on the Theological behaviour of microemulsions", Pharmazie, 49 (H10), 780-781 (1994)
  • 26. Fubini, B., Gasco, M.R., Gallarate, M., "Microcalorimetric study of microemulsions as potential drug delivery systems. II.Evaluation of enthalpy in the presence of drugs", Int. J.Pharm., 50, 213-217 (1989)
  • 27. Chew, C.H., Gan, L.M., Koh, L.L., Wong, M.K., "Microemulsions systems with monobutyl ether of ethylene glycol or diethylene glycol as cosurfactant", J.Disper.Sci.Technol, 9 (1), 17-31 (1988)
  • 28. Ward, A.J., O'Neill, K.J., "Microemulsions as topical drug delivery vehicles I.Characterization of a model system.", Drug Dev.Ind.Pharm., 14 (9), 1203-1219 (1988)
  • 29. Pattarino, F., Carlotti, M.E., Gasco, M.R., "Topical delivery systems for azelaic acid: Effect of the suspended drug in microemulsions", Pharmazie, 49 (H1), 72-73 (1994)
  • 30. Müller, B.W., Müller, R.H., "Particle size distributions and particle size alterations in microemulsions", J.Pharm.Sci, 73, 919-922 (July 1984)
  • 31. Bello, M., Colangelo, D., Gasco, M.R., Maranetto, F., Morel, S., Podio, V., Turco, G.L., Viano, L, "Pertechnetate release from a water/oil microemulsion and an aqueous solution after subcutaneous injection in rabbits" J.Pharm. Pharmacol, 46, 508-510 (1994)
  • 32. Cecutti, C, Novelli, A., Rico, I., Lates, A., "A new formulation for blood substitutes", J.Disper. Sci.Technol, 11 (2), 115-123 (1990)
  • 33. Halbert, G.W., Stuart, J.B., Florence, A.T., "The incorporation of lipid soluble antineoplastic agents into microemulsions protein-free analogues of low density lipoprotein", Int.J.Pharm., 21, 219-232 (1984)
  • 34. Gasco, M.R., Gallarate, M., Pattarino, F., "Invitro permeation of azelaic acid from viscosized microemulsions" Int.J.Pharm., 69, 193-196 (1991)
  • 35. Martin, A., Swarbrick, J., Cammarata, A., Physical Pharmacy, 3rd. ed., Lea and Febiger, Philadelphia, p. 470, 565-566 (1983)
  • 36. Rosoff, M., "Specialized Pharmaceutical Emulsions" in Pharmaceutical Dosage Forms, Lieberman, H.A., Rieger, M.M., Banker, G.S.(eds.), Marcel Dekker Inc., New York and Basel, 1, p. 268 (1988)
  • 37. Block, L .H., "Emulsions and Microemulsions" in Pharmaceutical Dosage Forms, Lieberman ,H.A., Rieger, M.M., Banker , G.S. (eds.) , Marcel Dekker Inc., New York and Basel, 2, p. 337-338 (1989)
  • 38. Ritschel, W.A., Ristchel, G.B., Sabouni, A., Wolochuk, D., Schroeder, T., "Study on the peroral absorption of the endekapeptide cyclosporine A" Meth. Find. Exp. Clin. Pharmacol, 11 (4), 281-287 (1989)
  • 39. Ritschel, W.A., Adolph, S., Ristchel, G.B., Schroeder, T., "Improvement of peroral absorption of cyclosporine A by microemulsions" Meth. Find. Clin. Pharmacol, 12 (2), 127-134 (1990)
  • 40. Ritschel, W.A., "Microemulsions for improved peptide absorption from the gastrointestinal tract" Meth. Find. Exp. Clin. Pharmacol, 13 (3), 205-220 (1991)
  • 41. Samama, J.P., "Enzymes and microemulsions. Activity and kinetic properties of liver alcohol dehidrogenase in ionic water-in-oil microemulsions" Eur. J. Biochem., 163 (3), (Medline Abs.: 609-17), (1987)