Investigations on the effect of base and solvents on the elimination of p-toluene sulphonyl group in the synthesis of dehydroalanine

Dehidroamino asitler belli peptid antibiyotiklerinin yapısını oluşturur ve önemli bir sınıf maddeyi temsil ederler. Yakın zamanda özellikle serin amino asitlerinden türeyen dehidroalanin olmak üzere, dehydroamino asitlerin hazırlanışlarına dikkate değer bir ilgi vardır. Bu çalışmada serin türevi bir bileşiğin dehidroalanine dönüşümünde farklı çözücü ve bazların etkileri N-benziloksikarbonil-O-tosilserin kullanılarak araştırılmıştır.

p-Toluen sülfonil grubu eliminasyonu ile dehidroalanin sentezinde baz ve solvanların etkilerinin araştırılması

Dehydroamino acids are constituents of certain peptide antibiotics and represent an important class of compound. Considerable attention has been given recently to the preparation of dehydroaminoacids, particularly of the dehydroalanine unit, which is generally derived from serine derivatives. In this study the conversion of a serine to a dehydroalanine unit using different base and solvents was investigated using N-benzyloxycarbonyl-O-tosyl derivative of serine.

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