SAPONİNLER VE DİABETES MELLİTUS ÜZERİNE POTANSİYEL ETKİLERİ

Hiperglisemi ile seyreden heterojen bir hastalık olan Diyabetes Mellitus, küresel düzeyde önemli bir sağlık sorunudur. Kronik hiperglisemi, çeşitli organların geri dönüşümsüz hasarına ve disfonksiyonuna neden olarak sağlık harcamalarını artırmakta ve yaşam kalitesini azaltmaktadır. Günümüzde diyabet tedavisinde kullanılan mevcut sentetik oral anti-diyabetik ilaçların yanında, anti-hiperglisemik aktiviteye sahip fitokimyasalların bitkilerden izolasyonu ile yan etkisi daha az alternatif ajanların bulunmasına yönelik ilgi artmıştır. Bu fitokimyasallardan biri olan saponinlerin; anti-tümör, anti-mikrobiyal ve anti-inflamatuar gibi çeşitli potansiyel terapötik etkilerinin yanında anti-hiperglisemik etkiye de sahip oldukları ifade edilmektedir. Bu makalede kanıta dayalı veriler ışığında saponinlerin antidiyabetik etkileri tartışılacaktır.

Anahtar Kelimeler:

Saponin, antihiperglisemi, insülin, diyabet

SAPONINS AND POTENTIAL EFFECTS ON DIABETES MELLITUS

Diabetes mellitus, a heterogeneous disorder characterized by hyperglycaemia, is an important global health problem. Chronic hyperglycemia causes irreversible damage and dysfunction of various organs, thereby increasing health expenditure and reducing quality of life. In recent years, besides the existing synthetic oral antidiabetic drugs used in the treatment of diabetes, there is an increased interest in the availability of alternative agents having less side effects and obtained by isolation of phytochemicals with antihyperglycemic activity from plants. Saponins, one of these phytochemicals, have anti-hyperglycemic activity as well as various potential therapeutic effects such as anti-tumor, anti-microbial and antiinflammatory. In this article, the antidiabetic effects of saponins will be discussed according to evidence based data.

Keywords:

Saponin, antihyperglycaemia, insülin, diabetes,

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