Özcan EREL, Alp ŞENER, Yunus Halil POLAT, Selda KIDAK ÖZKAYA, Gamze AVCIOĞLU, YAvuz OTAL, Servan GÖKHAN, Fadime Güllü HAYDAR

TIKANMA SARILIĞINDA OKSİDATİF STRESİN YENİ BİR BİYOLOJİK BELİRTECİ: DİNAMİK TİYOL-DİSÜLFİD HOMEOSTAZI

Amaç: Tiyol-disülfid(TDH) homeostazı birçok hastalıkta araştırılmıştır. Bu çalışmanın amacı, tıkanma sarılığı tanısı konan hastalarda dinamik tiyol-disülfid homeostazını araştırmak ve dinamik tiyol-disülfid homeostazını iskemi modifiye albümin ile karşılaştırmaktır. Materyal ve Metot: Acil servise başvuran 69 hasta ve 77 sağlıklı gönüllüden oluşan toplam 146 katılımcı çalışmaya dahil edildi. Hastalardan başvuru anında detaylı kan örnekleri alındı. Tıkanma sarılığı tanısı konulan hastalarda, başvuru sırasında Erel ve Neselioğlu tarafından geliştirilen yepyeni bir yöntemle tiyol/disülfit düzeylerine bakıldı. Veriler bilgisayar sisteminde değerlendirildi. Bulgular: Tıkanma sarılığı olan hastada total tiyol (p=0,025) ve nativ tiyol (p=0,023) düzeyleri kontrol grubuna göre istatistiksel olarak anlamlı derecede düşüktü. Nativ tiyol düzeyleri ile ALP (r =-0,262, p

A NEW BIOMARKER OF OXIDATIVE STRESS IN OBSTRUCTIVE JAUNDICE: DYNAMIC THIOLDISULPHIDE HOMEOSTASIS

Objectives: The thiol-disulphide (TDH) homeostasis was investigated in a number of disorders. The aim of the present study is to investigate the dynamic thiol-disulphide homeostasis in patients diagnosed with obstructive jaundice and to compare the dynamic thiol-disulphide homeostasis with ischemia-modified albumin. Materials and Methods: A total of 146 participants who were admitted to the emergency department and who consisted of 69 patients and 77 healthy volunteers were included in the study. Detailed blood samples were obtained from the patients at the time of admission. Thiol/disulphide levels were examined using a brand-new method developed by Erel and Neselioglu on the patients diagnosed with obstructive jaundice during the admission. Data were evaluated in the computer system. Results: The levels of total thiol (p =0.025) and native thiol (p =0.023) were statistically significantly lower in the patient with obstructive jaundice than in the control group. It was observed that there was a significant negative correlation between the native thiol levels and the ALP (r =-0.262, p

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