Cem ÖZİŞLER, Seçil Kepil ÖZDEMİR, Selcan GÜLTUNA

PRİMER SJÖGREN SENDROMLU HASTALARDA ATOPİK DURUMUN DEĞERLENDİRİLMESİ

AMAÇ: Farklı otoimmün hastalıklarda atopi prevalansı çeşitli çalışmalarla araştırılmıştır. Ancak primer Sjögren sendromlu (pSS) hastalardaki atopik durum henüz değerlendirilmemiştir. Çalışmamızda pSS ve atopi arasındaki ilişkiyi belirlemeyi amaçladık. GEREÇ VE YÖNTEM: PSS tanısı almış elli erişkin hasta ve yaş ve cinsiyet uyumlu elli tane kontrol çalışmaya alındı. pSS hastaları laboratuvar testleri ve hastalık aktivite skoru ile değerlendirildi. Tüm katılımcılara standart aeroalerjen paneliyle cilt prik testi uygulandı. BULGULAR: pSS grubunda 10 hastanın (10/50, %20) ve kontrol grubunda altı kişinin (6/50, %12) inhalen alerjen deri prik test sonuçları pozitif bulundu (p=0.267). Atopik ve atopik olmayan pSS hastaları arasında klinik özellikler açısından anlamlı fark bulunmadı. SONUÇ: PSS hastalarında atopik durum ve alerjen duyarlılığı değerlendirildi. Bildiğimiz kadarıyla bu, pSS hastalarında inhalen alerjen duyarlılığını araştıran ilk çalışmadır. Atopi prevalansı pSS'li hastalar ve kontroller arasında benzer bulundu.

EVALUATION OF ATOPIC STATUS IN PATIENTS WITH PRIMARY SJOGREN’S SYNDROME

AIM: The prevalence of atopy has been investigated in different autoimmune diseases in various studies. The atopic status in primary Sjögren’s syndrome (pSS) patients has not been evaluated yet. We aimed to determine the relationship between pSS and atopy. MATERIAL AND METHOD: Fifty consecutive adult patients with pSS and fifty age and sex-matched controls were recruited in this study. pSS patients were evaluated with laboratory tests and disease activity score. All subjects underwent skin prick test with a standard panel of common aeroallergens. RESULTS: Ten patients (10/50, 20%) in the pSS group and six participants (6/50, 12%) in the control group had positivity on skin prick tests with common inhalant allergens (p=0.267). No significant differences were found regarding the clinical characteristics between atopic and non-atopic pSS patients. CONCLUSIONS: Atopic status and allergen sensitization were evaluated in pSS patients. To our knowledge, this is the first study investigating the inhalant allergen spectrum in pSS patients. The prevalence of atopy is similar in patients with pSS to the controls.

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