Granuloma formation following ovariohysterectomy (OVH) can be caused by ligatures of nonabsorbable suture material and poor aseptic technique. To describe the clinical characterization of granulomas following OVH utilizing silk suture, two spayed bitches were reported. The variable clinical findings, ultrasonographic diagnosis and effectiveness of surgical therapy for treatment are discussed. Foreign body granulomas are important clinically cause of misdiagnosis tumours and stimulating new tumours. Practitioners should always consider elective OVH with ligation by nonabsorbable suture, however, often require surgical correction.