Kadın cinsel fonksiyon bozukluklarında fitoterapi
İnsan yaşamının önemli ve vazgeçilmez bir parçası olan cinsellik, biyo-psiko-sosyal nedenlere, kronik hastalıklara ve uygulanan tedavilere bağlı olarak olumsuz yönde etkilenebilmektedir. Cinsel fonksiyon bozukluklarının tedavisinde medikal ve cerrahi yaklaşımların yanı sıra fitoterapi de kullanılmaktadır. Bu derleme makale, kadın cinsel fonksiyonlarının geliştirilmesinde sık kullanılan Tribulus Terrestris, Yohimbin, Ginseng, Crocus Sativus, Maca, Ashwagandha, Mucuna Pruriens, Muira Puama, Ginkgo, Damiana, Black Cohosh gibi bitkisel ilaçlar hakkında literatür bilgisinin paylaşılması amacıyla yazıldı.
Phytotherapy in female sexual dysfunctions
Sexuality, an important and indispensable part of human life, can be adversely affected by bio-psycho-social causes, chronic diseases, and the treatments applied. Besides medical and surgical approaches, phytotherapy is also used in the treatment of sexual dysfunctions. This review article was written to share knowledge about herbal medicines such as Tribulus Terrestris, Yohimbine, Ginseng, Crocus Sativus, Maca, Ashwagandha, Mucuna Pruriens, Muira Puama, Ginkgo, Damiana, and Black Cohosh which are frequently used in the development of female sexual functions.
___
- Ventriglio A, Kalra G, Bhugra D. Human rights and sexuality:
sexual fluidity. Lancet Psychiatry 2018;5:109–10. [CrossRef]
- Lucas D, Fox J. The Psychology of Human Sexuality. In: BiswasDiener
R, Diener E, editors. The psychology of human sexuality.
Noba textbook series: Psychology. Champaign, IL: DEF publishers;
2018. http://nobaproject.com/modules/the-psychology-of-humansexuality
(Erişim tarihi: 14 Nisan 2018).
- Dominguez LJ, Barbagallo M. Ageing and sexuality. Eur Geriatr
Med 2016;7:512–8. [CrossRef]
- Greydanus DE, Pratt HD. Human sexuality. Int J Child Adolesc
Health 2016;9:291–312.
- Ni Lochlainn M, Kenny RA. Sexual activity and aging. J Am Med
Dir Assoc 2013;14:565–72. [CrossRef]
- Moreira ED, Glasser DB, Nicolosi A, Duarte FG, Gingell C;
GSSAB Investigators’ Group. Sexual problems and help-seeking
behaviour in adults in the United Kingdom and continental
Europe. BJU Int 2008;101:1005–11. [CrossRef]
- Gomaa AA, Abdel Aziz NM, Thabet RH, Fouly HA, Altellawy
SH, Gomaa GA. A Pilot Study of a Topical Intervention for
Treatment of Female Sexual Dysfunction. J Clin Psychopharmacol
2018;38:60–7. [CrossRef]
- Postigo S, Lima SM, Yamada SS, dos Reis BF, da Silva GM, Aoki T.
Assessment of the Effects of Tribulus Terrestris on Sexual Function
of Menopausal Women. Rev Bras Ginecol Obstet 2016;38:140–6.
[CrossRef]
- Fitoterapi. Sağlık Alanı Sertifikalı Eğitim Standartları, Sağlık
Bakanlığı Sağlık Hizmetleri Genel Müdürlüğü, Ankara. http://
dosyasb.saglik.gov.tr/Eklenti/3972,fitoterapi-sep---pdfpdf.pdf.
(Erişim tarihi: 09.05.2018)
- Parish SJ, Hahn SR. Hypoactive Sexual Desire Disorder: A Review
of Epidemiology, Biopsychology, Diagnosis, and Treatment. Sex
Med Rev 2016;4:103–20. [CrossRef]
- Brotto LA. Evidence-based treatments for low sexual desire in
women. Front Neuroendocrinol 2017;45:11–7. [CrossRef]
- Santoro N, Worsley R, Miller KK, Parish SJ, Davis SR. Role
of Estrogens and Estrogen-Like Compounds in Female Sexual
Function and Dysfunction. J Sex Med 2016;13:305–16.
[CrossRef]
- Pasha H, Basirat Z, Faramarzi M, Kheirkhah F. Pharmacological
and Non-pharmacological Therapeutic Strategies for Improvement
of State-Trait Anxiety: A Randomized Controlled Trial Among
Iranian Infertile Women With Sexual Dysfunctions. Crescent J
Med Biol Sci 2017;4:47–53.
- Bhandari B, Chopra D, Kohli SK. Pharmacological effects of
Tribulus Terrestris: A Review. IJCMR 2013;1:71–5.
- Shrestha PM, Dhillion SS. Medicinal plant diversity and use in
the highlands of Dolakha district, Nepal. J Ethnopharmacol
2003;86:81–96.
- Wani BA, Ganai BA, Ganaie AH, Bodha RH, Mohiddin FA.
Plants as repository of aphrodisiacs. J Pharm Res 2011;4:3882–7.
- Sivapalan SR. Biological and pharmacological studies of Tribulus
terrestris Linn-a review. Int J Multidiscip Res Dev 2016;3:257–65.
- Chhatre S, Nesari T, Somani G, Kanchan D, Sathaye S.
Phytopharmacological overview of Tribulus terrestris. Pharmacogn
Rev 2014;8:45–51. [CrossRef]
- da Cruz AC, Gonçalves Guerra N, Pacelhe de Souza KEB, de
Castro Eleutério I, da Silva LC, Otoni EG, et al. The action of
herbal medicine on the libido: aspects of nutritional intervention
in increasing sexual desire. Nutrire 2018;43:5. [CrossRef]
- Fatima L, Sultana A, Ahmed S, Sultana S. Pharmacological
activities of Tribulus terrestris Linn: a systemic review. World J
Pharm Pharm Sci 2015;4:136–50.
- Fatima L, Sultana A. Efficacy of Tribulus terrestris L. (fruits) in
menopausal transition symptoms: a randomized placebo controlled
study. Adv Integr Med 2017;4(2):56–65.
- Akhtari E, Raisi F, Keshavarz M, Hosseini H, Sohrabvand F, Bioos
S, et al. Tribulus terrestris for treatment of sexual dysfunction in
women: randomized double-blind placebo - controlled study.
Daru 2014;22:40. [CrossRef]
- Vale FBC, Zanolla Dias de Souza K, Rezende CR, Geber S.
Efficacy of Tribulus Terrestris for the treatment of premenopausal
women with hypoactive sexual desire disorder: a randomized
double-blinded, placebo-controlled trial. Gynecol Endocrinol
2018;34:442–5. [CrossRef]
- Gama CR, Lasmar R, Gama GF, Abreu CS, Nunes CP, Geller
M, et al. Clinical assessment of Tribulus terrestris Extract in the
Treatment of Female Sexual Dysfunction. Clin Med Insights
Womens Health 2014;22:45–50. [CrossRef]
- Rowland DL, Burek M, Macias L. Plant-derivatives and herbs used
for the promotion of sexual health and the treatment of sexual
problems. Annu Rev Sex Res 2007;18:225–57.
- Francois D, Levin AM, Kutscher EJ, Asemota B. Antidepressantinduced
sexual side effects: incidence, assessment, clinical implications,
and management. Psychiatric Annals 2017;47:154–60.
- Corazza O, Martinotti G, Santacroce R, Chillemi E, Giannantonio
MD, Schifano F, Cellek S. Sexual enhancement products for sale
online: raising awareness of the psychoactive effects of yohimbine,
maca, horny goat weed, and Ginkgo biloba. Biomed Res Int
2014;2014:841798. [CrossRef]
- Jacobsen FM. Fluoxetine-induced sexual dysfunction and an open
trial of yohimbine. J Clin Psychiatry 1992;53:119–22.
- Bolour SY, Braunstein GD. Pharmacologic treatment options
for hypoactive sexual desire disorder. Womens Health (Lond)
2005;1:263–77. [CrossRef]
- Tam SW, Worcel M, Wyllie M. Yohimbine: a clinical review.
Pharmacol Ther 2001;91:215–43.
- Meston CM, Worcel M. The effects of Yohimbine plus L-arginine
glutamate on sexual arousal in postmenopausal women with sexual
arousal disorder. Arch Sex Behav 2002;31:323–32.
- Tesch BJ. Herbs commonly used by women: an evidence-based
review. Am J Obstet Gynecol 2003;188(5 Suppl):S44–55.
- Rowland DL, Tai W. A review of plant-derived and herbal
approaches to the treatment of sexual dysfunctions. J Sex Marital
Ther 2003;29:185–205. [CrossRef]
- Tharakan B, Manyam BV. Botanical therapies in sexual dysfunction.
Phytother Res 2005;19:457–63. [CrossRef]
- Gün Ç, Demirci N. Menopozda bitkisel tedavi kullanımı. Arşiv
Kaynak Tarama Dergisi 2015;24:520–30. [CrossRef]
- Pellow J, McGrath L. Herbal medicine for low sexual desire in
menopausal women: A clinical review. Complement Ther Clin
Pract 2016;25:122–9. [CrossRef]
- Oh KJ, Chae MJ, Lee HS, Hong HD, Park K. Effects of Korean
red ginseng on sexual arousal in menopausal women: placebocontrolled,
double-blind crossover clinical study. J Sex Med
2010;7(4 Pt 1):1469–77. [CrossRef]
- Rahimi M. Chemical and Medicinal Properties of Saffron. Bull
Envi Pharmacol Life Sci 2015;4:69–81.
- Vahedi M, Govil S, Kumar S, Shrivastava D, Karimi R, Bisen PS.
Therapeutic applications of Crocus sativus L. (Saffron): a review.
Natural Products Journal 2016;6:1–10. [CrossRef]
- Tabeshpour J, Sobhani F, Sadjadi SA, Hosseinzadeh H, Mohajeri
SA, Rajabi O, et al. A double-blind, randomized, placebo-controlled
trial of saffron stigma (Crocus sativus L.) in mothers suffering
from mild-to-moderate postpartum depression. Phytomedicine
2017;36:145–52. [CrossRef]
- Lopresti AL, Drummond PD. Saffron (Crocus sativus) for
depression: a systematic review of clinical studies and examination
of underlying antidepressant mechanisms of action. Hum
Psychopharmacol 2014;29:517–27. [CrossRef]
- Licón C, Carmona M, Llorens S, Berruga MI, Alonso GL.
Potential healthy effects of Saffron spice (Crocus sativus L. stigmas)
consumption. Invited Review. Functional Plant Sci Biotechnol
2010;4:64–73.
- Selamoglu Z, Ozgen S. Therapeutic Potential of Saffron Crocus
(Crocus sativus L.). TURJAF 2016;4:1240–5. [CrossRef]
- Mokhber Maleki E, Eimani H, Bigdeli MR, Ebrahimi B, Shahverdi
AH, Golkar Narenji A, Abedi R. A comparative study of saffron
aqueous extract and its active ingredient, crocin on the in vitro
maturation, in vitro fertilization, and in vitro culture of mouse
oocytes. Taiwan J Obstet Gynecol 2014;53:21–5. [CrossRef]
- Singla RK, Bhat VG. Crocin: an Overview. Indo Global J Pharma
Sci 2011;1:281–6.
- Al-Snafi AE. The pharmacology of Crocus sativus-A review. IOSR
Journal of Pharmacy 2016;6:8–38.
- Rahmati M, Rahimikian F, Mirmohammadali M, Azimi K,
Goodarzi S, Mehran A. The effect of saffron on sexual dysfunction
in women of reproductive age ARTICLE INFO ABSTRACT.
Nurs Pract Today 2017;4:154–63.
- Kashani L, Raisi F, Saroukhani S, Sohrabi H, Modabbernia A,
Nasehi AA, et al. Saffron for treatment of fluoxetine-induced
sexual dysfunction in women: randomized double-blind placebocontrolled
study. Hum Psychopharmacol 2013;28:54–60.
[CrossRef]
- Dording CM, Fisher L, Papakostas G, Farabaugh A, Sonawalla
S, Fava M, Mischoulon D. A double-blind, randomized, pilot
dose-finding study of maca root (L. meyenii) for the management
of SSRI-induced sexual dysfunction. CNS Neurosci Ther
2008;14:182–91. [CrossRef]
- Mazaro-Costa R, Andersen ML. Hachul H, Tufik S. Medicinal
plants as alternative treatments for female sexual dysfunction:
utopian vision or possible treatment in climacteric women? J Sex
Med 2010;7:3695–714. [CrossRef]
- Shin BC, Lee MS, Yang EJ, Lim HS, Ernst E. Maca (L. meyenii)
for improving sexual function: a systematic review. BMC
Complement Altern Med 2010;10:44. [CrossRef]
- Brooks NA, Wilcox G, Walker KZ, Ashton JF, Cox MB,
Stojanovska L. Beneficial effects of Lepidium meyenii (Maca) on
psychological symptoms and measures of sexual dysfunction in
postmenopausal women are not related to estrogen or androgen
content. Menopause 2008;15:1157–62. [CrossRef]
- Mamidi P, Thakar AB. Efficacy of Ashwagandha (Withania
somnifera Dunal. Linn.) in the management of psychogenic
erectile dysfunction. Ayu 2011;32:322–8. [CrossRef]
- Ambiye VR, Langade D, Dongre S, Aptikar P, Kulkarni M, Dongre
A. Clinical Evaluation of the Spermatogenic Activity of the Root
Extract of Ashwagandha (Withania somnifera) in Oligospermic
Males: A Pilot Study. Evid Based Complement Alternat Med
2013;2013:571420. [CrossRef]
- Dongre S, Langade D, Bhattacharyya S. Efficacy and Safety of
Ashwagandha (Withania somnifera) Root Extract in Improving
Sexual Function in Women: A Pilot Study. Biomed Res Int
2015;2015:284154. [CrossRef]
- Kavitha C, Thangamani C. Amazing bean “Mucuna pruriens”: A
comprehensive review. J Med Plants Res 2014;8:138–43. [CrossRef]
- Lampariello LR, Cortelazzo A, Guerranti R, Sticozzi C, Valacchi G.
The Magic Velvet Bean of Mucuna pruriens. J Tradit Complement
Med 2012;2:331–9.
- Katzenschlager R, Evans A, Manson A, Patsalos PN, Ratnaraj N,
Watt H, et al. Mucuna pruriens in Parkinson’s disease: a double
blind clinical and pharmacological study. J Neurol Neurosurg
Psychiatry 2004;75:1672–7. [CrossRef]
- Daniel M. Medical Plants: Chemistry and Properties. New
Hampshire, US: Science Publishers; 2006. [Bağlantı] (Erişim
tarihi: 16 Nisan 2018)
- Misra L, Wagner H. Alkaloidal constituents of Mucuna pruriens
seeds. Phytochemistry 2004;65:2565–7. [CrossRef]
- Rathod BG, Patel NM. Development of Validated Rp-Hplc
Method for the Estimation of L-Dopa from Mucuna pruriens, Its
Extracts and In Aphrodisiac formulation. IJPSR 2014;5:508–13.
- Pandey J, Pandey R. Study of phytochemical and antimicrobial
activity of Alcoholic extract of Mucuna pruriens (L.) Leaves. Int J
Appl Res 2016;2:219–22.
- Singh R, Ali A, Gupta G, Semwal A, Jeyabalan G. Some medicinal
plants with aphrodisiac potential: A current status. J Acute Dis
2013;2:179–88. [CrossRef]
- Technical Data Report for MUIRA PUAMA Ptychopetalum
olacoides. Austin: Sage Press; 2003. http://www.rain-tree.com/reports/
muirapuama-tech.pdf (Erişim tarihi: 16 Nisan 2018)
- The Functions of Muira Puama for Female Libido. July 16, 2012
by Alice. http://www.femaleenhancementguide.org/the-functionsof-muira-puama-for-female-libido/
(Erişim tarihi: 09 Mayıs 2018)
- Meschino J. Natural Support for Sexual Performance & Libido
Enhancement in Men and Women. https://adeeva.com/documents/
res_rpt_libido_sensagen.pdf (Erişim tarihi: 09 Mayıs 2018).
- Waynberg J, Brewer S. Effects of herbal vX on libido and sexual
activity in premenopausal and post menopausal women. Adv Ther
2000;17:255–62.
- Pebdani MA, Taavoni S, Seyedfatemi N, Haghani H. Triple-blind,
placebo-controlled trial of Ginkgo biloba extract on sexual desire
in postmenopausal women in Tehran. Iran J Nurs Midwifery Res
2014;19:262–5.
- Çiftçi H. Erkek cinsel sağlığı için doğal afrodisyaklar. Harran
Üniversitesi Tıp Fakültesi Dergisi (Journal of Harran University
Medical Faculty) 2011;8:108–12.
- McKay D. Nutrients and botanicals for erectile dysfunction:
examining the evidence. Altern Med Rev 2004;9:4–16.
- Aung HH, Dey L, Rand V, Yuan CS. Alternative therapies for male
and female sexual dysfunction. Am J Chin Med 2004;32:161–73.
[CrossRef]
- Ünlüer E. Postmenopozal kadınlarda yılan otu tedavisinin vasküler
elastisite, kan lipid profili ve vazomotor semptomlar üzerine
etkilerinin araştırılması. Sağlık Bakanlığı Bakırköy Kadın ve Çocuk
Hastalıkları Eğitim ve Araştırma Hastanesi. Uzmanlık Tezi. Klinik
Şefi: Op. Dr. Ali İsmet Tekirdağ. İstanbul; 2005.
- West E, Krychman M. Natural Aphrodisiacs-A Review of Selected
Sexual Enhancers. Sex Med Rev 2015;3:279–88. [CrossRef]