A case of rare metabolic acidosis related to sorafenib therapy

Abstract: A 76-year-old female patient was followed up in the oncology clinic with a diagnosis of metastatic papillary thyroid carcinoma. Administration of Sorafenib, a vascular endothelial growth factor receptor (VEGFR) inhibitor, was initiated. Fifteen days after beginning treatment, the patient was admitted to the emergency department due to newly developed weakness, fatigue and impaired consciousness. The arterial blood gas examination of the patient revealed metabolic acidosis and the patient was admitted to the internal medicine clinic. Sorafenib therapy was discontinued, followed by administration of intravenous fluid and sodium bicarbonate therapies. Urine output and blood gas were closely monitored. Additionally, anti-acidosis tablet (2000 mg/day) treatment was started. After 5 days of treatment, routine blood gas results showed improvement and treatment was discontinued. The patient was discharged from the hospital and scheduled for follow-up at the outpatient clinic.

Keywords:

sorafenib, metabolic acidosis,

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