Obsesif kompulsif bozuklukta tiroid işlevleri etkilenmektedir

Amaç: Çalışmamızda, komorbid durumu olmayan obsesif kompulsif bozukluklu (OKB) bir grup hastada tiroid işlevlerinin incelenmesi amaçlanmıştır. Yöntem: Çalışmaya 40 OKB hastası ve 40 sağlıklı kontrol grubu alındı. Denekler, Fırat Üniversitesi Tıp Fakültesi Psikiyatri Bölümü’nde ayaktan veya yatarak tedavi gören ve çalışma ölçütlerini karşılayan OKB hastalarının dosyalarının geriye dönük taranmasıyla seçildi. Tiroid hormon değerleri auto-analizer kullanılarak elde edildi. Bulgular: Bağımsız t testi, tiroid salgılatıcı hormon (TSH) düzeylerinin OKB grubu ile sağlıklı kontrol grubu arasında istatistiksel olarak anlamlı fark olmadığını, serbest triiyodotironin ve sebest tiroksin düzeylerinin ise hasta grubunda, kontrol grubuna göre istatistiksel olarak anlamlı düzeyde azaldığını ortaya koymuştur. Sonuç: Sonuç olarak, tiroid hormonlarının düzeylerindeki değişiklik, OKB’nin patofizyolojisiyle veya en azından hastalığın kliniğinin sürmesiyle ilişkili olabilir.

Thyroid gland functions are affected in obsessive compulsive disorder

Objective: In the present study, it was aimed to examine thyroid functions in a group of patients with obsessivecompulsive disorder (OCD) who had not any comorbid conditions. Methods: Our present study included fortypatients diagnosed with OCD and forty healthy controls. The subjects were selected by the chart reviews amongthe patients with OCD who had applied to the Firat University School of Medicine Department of Psychiatry, asinpatients or outpatients and had met the criteria of the present investigation. Thyroid hormone values had beenobtained by using an auto analyzer. Results: Independent t test revealed that there were no statistically significantdifferences thyroid stimulating hormone (TSH) values between the patients with OCD and healthy control subjectswhereas there were statistically significant reduced levels of free triiodothyronine (FT3) and free thyroxine (FT4)hormones in the patient group compared to those of healthy ones. Conclusion: Consequently, altered levels ofthyroid hormones may be associated with pathophysiology or at least maintenance of OCD.

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