Hızlı döngülü ve hızlı olmayan bipolar bozukluk hastalarının bazı klinik özelliklerini karşılaştıran kesitsel bir çalışma

Amaç: Literatür, bipolar bozuklukta (BB) hızlı döngü özelliğinin (HD) daha kötü hastalık sonucu ve daha ciddi malu- liyet ile ilişkili olduğunu göstermektedir. Son 12 ayda HD'yi etkileyen veya artmasında etkili etkenleri araştırmayı amaçladık. Yöntem: Bu bir kesitsel çalışmadır. Hastalar (s=380) genel bir hastanenin polikliniklerinden alındı. Tanı görüşmelerinde DSM-IV Bozuklukları için Yapılandırılmış Klinik Görüşme (SCID-I) ve SCID-II uygulandı. Sosyode- mografik Form, Young Mani Derecelendirme Ölçeği (YMRS) ve Hamilton Depresyon Ölçeği (HDÖ) uygulandı. HD, önceki 12 ayda dört veya daha fazla duygudurum nöbetinin varlığı olarak tanımlandı. Hastalar hızlı döngülü bipolar bozukluk (HDBB) tanısı olup olmadıklarına göre ayrıldı. HDBB hasta grubu, HDBB olmayan hasta grubuyla sosyo- demografik ve klinik veriler açısından karşılaştırıldı. Sonuçlar: Çalışma grubunda kadınlar daha yüksek orandaydı (%65.0). Altmış hastada (%15.8) son 12 ayda HD vardı. İntihar girişimi sayısı, duygudurum bozuklukları aile öyküsü, psikotik depresyon, kullanılan antidepresan sayısı, manik, depresif, karışık ve toplam nöbet sayısı açısından iki grup grup arasında istatistiksel olarak anlamlı farklılıklar bulundu. Tartışma: Son 12 ayda HD varlığı, BB gidişinde daha kötü sonuçlarla yakından ilişkili özgül klinik özellikler ile ilişkili bulundu. Standart tanımı yapılmış ve homojen HDBB hasta gruplarında hastalıkla ilişkili etkenlerin açığa çıkartılması için daha fazla çalışmaya gerek vardır. (Anadolu Psikiyatri Derg 2019; 20(5):477-484)

A cross-sectional study comparing some clinical features of patients with rapid cycling and non-rapid cycling bipolar disorder

Objective: Literature indicates that rapid cycling (RC) feature in bipolar disorder (BD) has been associated withworse disorder outcome and more severe disability. We aimed to investigate factors that affect or involved invulnerability to increase rapid cycling in the previous 12 months. Methods: This is a cross-sectional study. Patients(n=380) were recruited from an outpatients clinic of a general hospital. Diagnostic interviews were performed withStructured Clinical Interview for DSM-IV Disorders (SCID-I) and SCID-II. Sociodemographic Form, Young ManiaRating Scale (YMRS) and Hamilton Depression Rating Scale (HAM-D) were applied. RC was defined as presencefour or more mood episodes in the previous 12 months. Patients were arranged as whether having rapid cyclingbipolar disorder (RCBD) or not. RCBD was compared to the group of non-RCBD patients regarding the sociode-mographic and clinical data. Results: Study group showed a female preponderance (65.0%). Sixty patients (15.8%)had RC in the previous 12 months. There were statistically significant differences between two groups regarding innumber of suicide attempts, family history of mood disorders, psychotic depression, number of antidepressantsutilized, manic, depressive, mixed and total number of episodes. Discussion: The presence of RC in the previous12 months was found correlated with specific clinical features closely related to worse outcome in the course of BD.Further studies are needed to clarify disease-related factors in patient groups with a standard definition of homo-geneous RCBD. (Anatolian Journal of Psychiatry 2019; 20(5):477-484)

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