Hasan Mervan AYTAÇ, Tonguç Demir BERKOL, ZENGİBAR ÖZARSLAN, NAZAN AYDIN

A common possible genetic etiology in trichotillomania and posttraumatic stress disorder comorbidity: a case report

Trichotillomania (TTM) is a psychiatric disorder can be triggered by traumatic events characterized by recurrent hair pulling. The incidence of post-traumatic stress disorder (PTSD) in TTM patients was also significantly higher than in the normal population. It is estimated that serotonergic system, dopaminergic system, hypothalamic-pituitary- adrenal (HPA) axis genes may be related with PTSD and TTM co-occurrence. When the literature is reviewed it is seen that serotonergic system gene especially 5HT-2A gene polymorphism may play an important role as a com- mon possible genetic background in the etiology of posttraumatic stress disorder and trichotillomania. It was also observed that effective results were obtained when agents acting on 5HT-2A receptor were preferred in the treatment. Here, we report a 20-year-old male patient who was diagnosed with TTM and PTSD as a result of trau- matic life event a year ago and we also aimed to discuss a possible common genetic etiology which may cause this comorbidity. (Anatolian Journal of Psychiatry 2019; 20(1):110-112)

Trikotillomani ve travma sonrası stres bozukluğu komorbiditesinde ortak olası genetik etiyoloji: Bir olgu sunumu

Trikotillomani (TTM) yineleyen saç yolma davranışı ile karakterize, travmatik olaylarla tetiklenebilen bir psikiyatrik bozukluktur. TTM hastalarında travma sonrası stres bozukluğu (TSSB) görülme sıklığı normal insanlara göre anlam- lı derecede yüksektir. Serotonerjik sistem, dopaminerjik sistem ve hipotalamo-hipofiz-adrenal (HPA) aks genlerinin TSSB ve TTM hastalığının eş zamanlı meydana gelmesi ile ilişkili olabileceği tahmin edilmektedir. Literatürde özellikle 5HT-2A serotonerjik sistem gen polimorfizminin, travma sonrası stres bozukluğu ve trikotillomaninin etiyo- lojisinde ortak olası genetik temel olarak önemli rol oynayabileceği görülmekle birlikte, uygulamada da tedavide 5HT-2A reseptörü üzerine etkili ajanlar tercih edildiğinde olumlu sonuçların alındığı görülmektedir. Bu olgu sunu- munda da, bir yıl önce uğradığı travmatik bir yaşantı sonucunda gelişen TSSB ve buna eşlik eden TTM’si olan 20 yaşındaki erkek hasta, mevcut komorbiditeye neden olabilecek altta yatan olası ortak genetik etiyolojinin ışığında ele alınmıştır. (Anadolu Psikiyatri Derg 2019; 20(1):110-112)

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