Mithat TERZİ, Yasin ÇİÇEK, Alparslan DİLSİZ

Menopozun sağlıklı ve periodontitisli kadınlarda kortizol, alfa-amilaz, dopamin ve prolaktin seviyeleri üzerine etkisi: kesitsel bir çalışma

Amaç: Bu çalışmada menopozun sağlıklı ve periodontitisli kadınlarda serum kortizol, alfa-amilaz, dopamin ve prolaktin seviyeleri üzerindeki etkisini araştırmak amaçlanmıştır.Yöntem: Çalışmaya toplam 80 kadın dahil edildi. Hastalar, Periodontal ve Peri-İmplant Hastalık ve Durumların Sınıflandırılmasına Dair 2017 Dünya Çalıştayı kriterlerine göre teşhis edildi. Klinik muayenede plak indeksi (Pİ), gingival indeks (Gİ), sondalama cep derinliği (SCD) ve klinik ataşman kaybı (KAK) ölçümleri yapıldı. Sistemik kortizol, alfa-amilaz, dopamin ve prolaktin seviyeleri biyokimyasal olarak ölçüldü. Veriler istatistiksel olarak analiz edildi.Bulgular: Ortalama katılımcı yaşı 44,32±3,23 (aralık: 33–55) yıl idi. Ortalama Pİ 0,98±0,10; Gİ 0,94±0,31; SCD 2,59±0,23 mm, KAK 2,65±0,16 mm idi. Menopozlu kadınlarda prolaktin seviyeleri istatistiksel olarak anlamlı biçimde daha düşükken (p<0,05), kortizol, alfa-amilaz ve dopamin seviyelerindeki değişimler anlamlı değildi (p>0,05). Periodontitisli kadınlarda kortizol, dopamin ve prolaktin seviyeleri anlamlı biçimde yüksekti (p<0,05).Sonuç: Menopozun sağlıklı ve periodontitisli kadınlarda klinik periodontal parametreler ve kortizol, alfa-amilaz ve dopamin seviyeleri üzerinde etkisi olmadığı görüldü. Ancak menopoz periodontal hastalık varlığından bağımsız olarak azalmış prolaktin seviyeleri ile ilişkili idi.

Anahtar Kelimeler:

menopoz, periodontitis, psikolojik stres

The effect of menopause on levels of cortisol, alpha-amylase, dopamine, and prolactin in women with periodontitis and healthy controls: a cross sectional study

Aim: In this study, we aimed to investigate the effects of menopause on serum levels of cortisol, alpha-amylase, dopamine, and prolactin in women with periodontitis and healthy controls.Methods: The study included a total of 80 women. Patients were diagnosed according to the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions criteria. The clinical examination included plaque index (PI), gingival index (GI), probing depth (PD), and clinical attachment loss (AL) measurements. The systemic levels of cortisol, alpha-amylase,dopamine, and prolactin were measured biochemically. Data were analyzed statistically. Results: The mean participant age was 44.32±3.23 (range: 33–55) years. The mean PI was 0.98±0.10, GI 0.94±0.31, PD 2.59±0.23 mm, and AL 2.65±0.16 mm. While prolactin levels were statistically significantly lower in menopausal women (p<0.05), the changes in cortisol, alpha-amylase, and dopamine levels were not significant (p>0.05). Levels of cortisol, dopamine and prolactinwere found to be significantly high in women with periodontitis (p<0.05).Conclusion: It was found that menopause had no effect on the clinical periodontal parameters and levels of cortisol, alpha-amylase, and dopamine in women with periodontitis and healthy controls.However, menopause was associated with decreased prolactin levels, independent of the presence of periodontal disease.

Keywords:

menopause, periodontitis, stress hormones,

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