Mehmet Rifat GÖKLÜ, Şeyhmus TUNÇ, Şerif AKSİN, Cengiz ANDAN

Koronavirüs hastalığı 2019 tanısı konmuş gebe kadınlarda proinflamatuar interlökin-6 ve anti-inflamatuar interlökin-10 sitokinlerinin etkileri

Amaç: Çalışmamızda Koronavirüs Hastalığı (COVID)-19 pozitif gebelerde serum interlökin (IL)-6 ve IL-10 düzeyleri ile hastalığın seyri arasındaki ilişkinin araştırılması amaçlandı.Yöntemler: Çalışmamızda 28 üçüncü trimester COVID-19 pozitif gebe ve 30 üçüncü trimester sağlıklı gebede serum IL-6 ve IL-10 düzeyleri ölçüldü. COVID-19 pozitif vakalar, taşıyıcı veya hasta olarak sınıflandırıldı. Çalışma grubundaki gebelerden 13’ü asemptomatik iken veya hafif hastalık nedeniyle takip edilirken; 7’si yoğun bakım ünitesinde (YBÜ) olmak üzere toplam 15 hamile kadın hastaneye kaldırılarak tedavi altına alındı. COVID-19 pozitif gebe kadınların IL-6 ve IL-10 testleri ilk uygulama sırasında çalışıldı.Bulgular: COVID-19’lu 7 (%25) hastanın yoğun bakım ünitesine kabul edilmesi gerekti. COVID-19 negatif gebelerde IL-6 düzeyi, COVID-19 taşıyıcısı ve hasta gebelere göre anlamlı derecede düşük bulundu (p=0,01). COVID-19 negatif olan gebelerde IL-10 düzeyi, COVID-19 taşıyıcısı olan gebelere (p=0,002) ve hastalara (p=0,002) göre anlamlı derecede yüksek bulundu.Sonuç: Şüpheli veya doğrulanmış bir COVID-19 teşhisi ile başvuran hamile kadınlarda olumsuz sonuç riskini en aza indirmek için IL-6 ve IL-10 sitokin düzeylerinin yakından izlenmesi önerilir. Bu şekilde hamile kadınlarda orta-hafif COVID-19’u şiddetli COVID-19’dan ayırt etmek mümkün olabilir.

Anahtar Kelimeler:

COVID-19, gebelik, interlökin-6, interlökin-10

Effects of pro-inflammatory interleukin-6 and anti-inflammatory interleukin-10 cytokines in pregnant women diagnosed with coronavirus disease 2019

Aim: This study aims to investigate the relationship between serum interleukin (IL)-6 and IL-10 levels in coronavirus disease (COVID)-19 positive pregnant women and the course of the disease.Methods: In our study, serum IL-6 and IL-10 levels were measured in 28 third-trimester COVID-19-positive pregnant women and 30 third-trimester healthy pregnant women. COVID-19-positive cases were classified as carriers or patients. While 13 of the pregnant women in the study group were asymptomatic or were being followed out due to mild illness; a total of 15 pregnant women, 7 of whom were in the intensive care unit (ICU), were hospitalized and treated. IL-6 and IL-10 tests of COVID-19-positive pregnant women were studied at the time of first application.Results: Seven (25%) patients with COVID-19 required admission to an ICU. The IL-6 level was found to be significantly lower in COVID-19-negative pregnant women compared to pregnant women who were COVID-19 carriers and patients (p=0.01). The IL-10 level was found to be significantly higher in pregnant women who were negative for COVID-19 compared to pregnant women who were COVID-19 carriers (p=0.002) and patients (p=0.002).Conclusion: Close monitoring of IL-6 and IL-10 cytokine levels is recommended to minimize the risk of adverse outcomes in pregnant women presenting with a suspected or confirmed diagnosis of COVID-19. In this way, it may be possible to distinguish moderate–mild COVID-19 from severe COVID-19 in pregnant women.

Keywords:

COVID-19, interleukin-6, interleukin-10, pregnancy,

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