Ali ASLAN, Mürüvvet AKÇAY ÇELİK, Arzu ŞAHİN, Havva ERDEM, Soner ÇANKAYA

Kolon Poliplerinde WT1 Ekspresyonunun İncelenmesi

Amaç: WT1, ilk olarak Wilms tümörü gelişimini etkileyen tümör baskılayıcı bir gen olarak tespit edilmişolsa da, kolon kanseri gibi bazı malignitelerde ekspresyonunun arttığı, dolayısıyla onkojenik özelliklerininolduğu da bildirilmektedir. Bu çalışmanın amacı WT1 ekspresyonunun hastanın yaşına, cinsiyetine,örneğin alındığı bölgeye ve patolojik tanı türüne göre değişip değişmediğini tespit etmektir.Gereç ve Yöntemler: Patoloji anabilim dalına gönderilmiş kolon polipli 32 hastaya ait parafin bloklarınve patoloji raporlarının retrospektif histopatolojik değerlendirilmesi yapılmıştır. İstatistiksel olarakp

An Investigation of WT1 Expression in Colon Polyps

Aim: Although WT1 was first identified as a tumor suppressor gene affecting Wilms’ tumor development, it has also been reported that its expression increases in certain malignancies such as colon cancer, and that it therefore has oncogenic properties. In this study, we aimed to determine dependence of WT1 expression on patient age and sex, type of pathological diagnosis, and the sample-taking area. Materials and Methods: Paraffin-embedded blocks and pathology reports of 32 patients with colon polyps that had been sent to pathology department were histopathologically reviewed retrospectively. p

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