Sjögren Sendromu Ön Tanısı ile Minör Tükürük Bezi Biyopsisi Yapılan Hastalarda Biyopsi Sonuçlarıyla Serolojik Testlerin Karşılaştırılması.

Amaç: Sjögren sendromu egzokrin bezlerin lenfositik infiltrasyonu ile karakterize otoimmün inflamatuvar bir hastalıktır. Sjögren sendromu için çeşitli serolojik testler, semptomlar, histopatolojik bulguları içeren farklı sınıflandırma kriterleri bulunmaktadır. Bu çalışmada minör tükürük bezi biyopsi sonuçları ile serolojik özellikler arasındaki ilişkinin değerlendirilmesi amaçlandı. Gereç ve Yöntemler: Minör tükürük bezi biyopsisi ile anti nükleer antikor, ekstrakte nükleer antijen, anti dense fine speckled 70 antikor sonuçları arasındaki ilişki değerlendirildi. İstatistiksel önemlilik için p< 0,05 ise anlamlı kabul edildi. Bulgular: Çalışmaya 77 hasta (71K, 6E) dahil edildi. Hastaların %22,1’inde anti nükleer antikor dense fine speckled paterndeydi. Hastaların %31,2’sinde biyopsi sonucu histopatolojik olarak kesin Sjögren sendromu ile uyumluydu (fokus skoru≥1). Hastaların %19,5’inde anti dense fine speckled 70 antikor, %26’sında anti SS-A antikor pozitifti. Anti dense fine speckled 70 antikor pozitifliği olan 15 hastanın 7’si Sjögren sendromu tanısı aldı. Anti dense fine speckled 70 antikor pozitif ve negatif hastalar arasında Sjögren sendromu tanısı açısından ve biyopsi pozitifliği açısından fark yoktu (p=0,905, p=0,996). Sonuç: Minör tükürük bezi biyopsisi Sjögren sendromu tanısında çok önemli bir yere sahiptir. Anti nükleer antikor, anti SS-A ve anti SS-B antikorları negatif olan hastalarda minör tükürük bezi biyopsisi Sjögren sendromu tanısı koyma şansı vermektedir. Tek başına anti dense fine speckled 70 antikor pozitifliği Sjögren sendromu tanısını dışlamamaktadır.

Anahtar Kelimeler:

Minör Tükürük Bezi Biyopsisi, Sjögren Sendromu, Anti Dense Fine Speckled Antikor

Comparison of the Minor Salivary Gland Biopsy Results and Serological Tests in Patients Performed Minor Salivary Gland Biopsy with Preliminary Diagnosis of Sjögren Syndrome.

Objective: Sjogren's syndrome is an autoimmune inflammatory disease characterized by lymphocytic infiltration of the exocrine glands. There are various classification criteria for Sjögren's syndrome which include various serological tests, symptoms, and histopathological findings. In this study, it was aimed to evaluate the relationship between minor salivary gland biopsy results and serological features. Material and Methods: The relationship between minor salivary gland biopsy and anti-nuclear antibody, extracted nuclear antigen, and the dense specled antibody results were evaluated. P <0.05 was considered significant. Results: 77 patients (71F, 6M) were included in the study. In 22.1% of the patients the anti-nuclear antibody was in a fine speckled pattern. The 31.2% of the patients was histopathologically compatible with Sjögren syndrome (focus score≥1). Anti dense fine speckled 70 antibody was positive in 19.5% of the patients and anti SS-A antibody in 26%. Seven of the 15 patients with anti dense fine speckled 70 antibody positivity were diagnosed with Sjögren's syndrome. There was no difference between anti dense fine speckled 70 antibody positive and negative patients in terms of diagnosis of Sjögren's syndrome and biopsy positivity (p = 0.905, p = 0.996). Conclusion: Minor salivary gland biopsy has very important place in diagnosis of Sjögren syndrome. Minor salivary gland biopsy gives the chance to diagnose Sjögren's syndrome in patients with negative anti nuclear antibodies, anti SS-A and anti SS-B antibodies. İsolated anti dense fine speckled 70 antibody positivity does not exclude Sjögren syndrome.

Keywords:

Anti Dense Fine Speckled 70 Antibody, Minor Salivary Gland Biopsy, Sjögren,

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