Osman Vefa GÜL, Gökçen İNAN, Hamit BAŞARAN

Serviks Kanseri İçin İki Farklı Brakiterapi Tedavi Planlama Tekniğinin Dozimetrik Karşılaştırması

ÖZ Amaç: Bu çalışmanın amacı, servikal kanserin brakiterapisinde manuel olarak optimize edilmiş (MO) planlama yaklaşımı ile inverse optimize edilmiş (IO) planlama yöntemleri arasındaki dozimetrik farklılıkları değerlendirmektir. Gereç ve Yöntemler: Bu çalışmaya on beş hasta dahil edildi. Yüksek riskli klinik hedef hacim (CTVHR) ve orta riskli hedef hacim (CTVIR) CTV'ler olarak tanımlandı, ayrıca riskli organlar olarak (OAR) rektum, mesane, ince bağırsak, sigmoid ve üretra tanımlandı. Her hasta için iki farklı tedavi planları oluşturuldu. Bütün hastalara 50.4 Gy external ışın radyoterapisi (EBRT) uygulandıktan sonra, 4 fraksiyonda 28 Gy yüksek doz oranı (HDR) tümör merkezine verildi. Bu tedavi planlarından alınan dozimetrik sonuçlar, CTV'ler, OAR'lar, uygunluk indeksi (CI) ve toplam tedavi süresi gibi dozimetrik parametreler karşılaştırıldı. Bulgular: CTVHR’ in D90, CTVIR’in D50 için anlamlı fark bulunamamıştır fakat CTVHR’ in D98 değeri için (p

Anahtar Kelimeler:

Brakiterapi, Serviks kanseri, İnverse optimizasyon, Manuel optimizasyon

Dosimetric Comparison of Two Different Brachytherapy Treatment Planning Techniques for Cervical Cancer

Objective: The purpose of this study was to evaluate thedosimetric differences between inverse optimized (IO) planning methods with the manual optimized (MO) planning approach for brachytherapy of cervical cancer. Methods: Fifteen patients were included in this study. High-risk clinical target volume (CTVHR) and intermediate-risk CTV (CTVIR) were defined as CTVs, and rectum, bladder, smallbowel, sigmoid andurethra, were defined as organs at risk (OARs). Two different treatment plans were created for each patient: MO and IO. After all patients received 50.4 Gy external beam radiotherapy (EBRT), 28 Gy high-dose-rate (HDR) in 4 fractions was delivered to central disease. Dosimetric outcomes from these treatment plans were compared dosimetric parameters, such as CTVs, OARs, conformity index (CI) and total dwell time. Results: There were nosignificant differences in D90values of CTVHR and D50values of CTVIR, however significant differences were found D98values of CTVHR(p

Keywords:

Brachytherapy, Cervix cancer, Inverse optimization, Manual optimization,

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