Hasan Şenol ÇOSKUN, Gülsüm Özlem ELPEK, Melek ERYILMAZ KARAKURT, Betül ÜNAL, Derya SALİM KIVRAK, Fatma MÜSRİ YALÇIN, Hasan MUTLU

Parotis Bezinin Primer Malign Melanomu: Alışılmadık Primer Alan

Parotis bezinin malign melanomu alışılmadık bir lokalizasyon olup literatürde nadiren bildirilen istisnai bir durumdur. Farklı tedavi ve prognozlarından dolayı parotis bezinin primer malign melanomu ile malign melanomun parotise metastazının ayırımı kritiktir. Biz sağ parotiste şişlik ile başvuran 57 yaşındaki bir kadın hastayı sunduk. Hastaya sağ parotidektomi yapıldı. İmmünhistokimyasal olarak tümör hücreleri S-100, HMB-45 ve Melan A ile pozitif boyanıyordu. Değerlendirmede primer olabilecek başka bir odak bulunmadığından hastaya parotis bezinin primer malign melanomu teşhisi konuldu.Parotis bezinin malign melanomu nadir bir teşhis olmakla birlikte, klinisyenler parotis tümörlerinin farklı teşhisinde bu prezentasyonun farkında olmalıdır

Anahtar Kelimeler:

Malign melanom, Parotis bezi, Metastaz

Primary Malignant Melanoma of the Parotid Gland: rimary Malignant Melanoma of the Parotid Gland: An Unusual Primary Site

Malignant melanoma MM of the parotid gland arising at such an unusual location is an exceptional and rare case only occasionally mentioned in the literature. Due to the different treatments and prognosis, a distinction between primary parotid gland MM and metastasis of MM is crucial.We report on a 57-year-old woman who presented with right parotid swelling.She underwent right total parotidectomy. Immunohistochemically, the tumor cells were positive staining for S-100, HMB-45, and Melan A. Since no other focus was detected, the patient was diagnosed with primary malignant melanoma of the parotid gland. Although malignant melanoma of the parotid gland is a rare diagnosis, clinicians should be aware of this presentation in the differential diagnosis of parotid tumors

Keywords:

Malignant melanoma, Parotid gland, Metastasis,

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1. Kim HS, Kim EK, Jun HJ, Oh SY, Park KW, Lim do H, Lee SI, Kim JH, Kim KM, Lee DH, Lee J. Noncutaneous malignant melanoma: A prognostic model from a retrospective multicenter study. BMC Cancer 2010;10:167.
2. Guy GP Jr, Thomas CC, Thompson T, Watson M, Massetti GM, Richardson LC; Centers for Disease Control and Prevention (CDC). Vital signs: Melanoma incidence and mortality trends and projections - United States, 1982-2030. MMWR Morb Mortal Wkly Rep 2015;64(21):591-6.
3. Robert C, Karaszewska B, Schachter J, Rutkowski P, Mackiewicz A, Stroiakovski D, Lichinitser M, Dummer R, Grange F, Mortier L, Chiarion-Sileni V, Drucis K, Krajsova I, Hauschild A, Lorigan P, Wolter P, Long GV, Flaherty K, Nathan P, Ribas A, Martin AM, Sun P, Crist W, Legos J, Rubin SD, Little SM, Schadendorf D. Improved overall survival in melanoma with combined dabrafenib and trametinib. N Engl J Med 2015;372(1): 30-9.
4. Wilkins DK, Nathan PD. Therapeutic opportunities in noncutaneous melanoma. Ther Adv Med Oncol 2009;1(1): 29-36.
5. Hughes T, Klairmont M, Sharfman WH, Kaufman HL. Interleukin-2, Ipilimumab, and Anti-PD-1: Clinical management and the evolving role of immunotherapy for the treatment of patients with metastatic melanoma. Cancer Biol Ther 2015:0.
6. DePeralta DK, Boland GM. Melanoma: Advances in targeted therapy and molecular markers. Ann Surg Oncol 2015;22(11):3451-8.
7. Maier H, Mühlmeier G, Kraft K, Blumstein NM, Tisch M Primary malignant melanoma of the parotid gland: a case report and review of the literature. HNO 2008;56(6):627- 32. (In German).
8. Takeda Y. Melanocytes in the human parotid gland. Pathol Int 1997;47(8): 581-3.
9. Vuong PN, Cassembon F, Houissa-Vuong S, Koubbi G, Balaton A. Primary malignant melanoma of the parotid gland: anatomico-clinical study. Apropos of a case and review of the medical literature. Ann Otolaryngol Chir Cervicofac 1986;103(1):45-55. (In French).
10. Woodwards RT, Shepherd NA, Hensher R. Malignant melanoma of the parotid gland: A case report and literature review. Br J Oral Maxillofac Surg 1993;31(5):313-5.
11. Bahar M, Anavi Y, Abraham A, Ben-Bassat M. Primary malignant melanoma in the parotid gland. Oral Surg Oral Med Oral Pathol 1990;70(5):627-30.
12. Bangerter M. Cytomorphologic pitfall of primary malignant melanoma of the parotid gland: A case report. Acta Cytol 2009;53(4):435-6.