Hüseyin Özgür KAZANCI, Tanju MERCAN, Emel ALİMOĞLU, Murat CANPOLAT

Meme Lazer Tomografi Sisteminin Tasarımı ve Pilot Klinik Çalışma Sonuçları

Amaç: Akdeniz Üniversitesi Tıp Fakültesinde geliştirilen Meme Lazer Optik Tomografi MLT sisteminin meme lezyonlarını saptamadaki etkinliğini değerlendirmek. Gereç ve Yöntemler: Çalışmaya toplam 10 hastada 13 lezyon dâhil edildi. MLT sistemi optik prob, elektronik kartlar, bir 1x49’luk optik anahtardan, dalga boyu 808 nm olan diyot lazerden, oluşmaktadır. Önce bütün hastaların memeleri ultrasonografi, mamografi veya manyetik rezonans görüntüleme ile incelendi. Tüm hastalarda ele gelen kitle bulunmaktaydı. Hasta sırt üstü yatarken fiber optik prob hastanın memesindeki kitle bölgesine hafifçe değdirilerek MLT sistemi ile ölçümler alındı. Sağlam meme simetrik bölgesinde alınan ölçümler kontrol gurubu olarak kullanıldı. Ölçümlerden sonra yedi lezyona ultrason altında kor biyopsi, bir hastaya ise cerrahi biyopsi yapıldı. MLT sistemi ile alınan görüntüler radyolojik bulgular ve biyopsi sonuçları ile karşılaştırılarak değerlendirildi. Bulgular: Biyopsi yapılan lezyonlardan beş tanesi invaziv duktual karsinoma, biri lobular karsinoma, biri adenozis ve biri papilloma olarak sonuçlandı. Diğer beş lezyon bir hamartoma, bir postoperativ skar doku, iki kist ve bir mastit ultrasound, MRI ve/veya mamografi ile teşhis edildi. Malign, benign ve mastit olgularında normal meme dokusuna göre daha yüksek kontrast görüldü. Hamartoma, kist ve skar dokusu ise normal meme dokusu ile karşılaştırıldığında bir kontrast oluşturmadı. Sonuç: MLT ile neoplazilerin hamartoma ve kist gibi diğer meme patolojilerinden ayırt edilebildiği gösterildi. Bundan dolayı MLT sisteminin diğer radyolojik görüntüleme sistemleri ile beraber klinikte kullanılma potansiyeli bulunmaktadır

Anahtar Kelimeler:

Lazer, Meme, Tomografi

Design of Breast Laser Tomography System and Pilot Clinical Results

Objective: To evaluate the capacity of the breast diffuse optical tomography system to detect breast lesions. The system has been developed in our Faculty of Medicine.Material and Methods: The breast diffuse optical tomography system consists of an optical fiber probe, electronics boards, one 1x49 optics switch and a diode laser with a wavelength of 808 nm. Thirteen lesions from 10 patients were examined using ultrasound, mammography or magnetic resonance imaging MRI . All the patients had a palpable lump or mass located superficially. The optical probe was then placed gently on the breast with the patient in the supine position. The first measurement was taken on the lesion and the second from the symmetrical counterpart of the other breast as a control group. After the measurements, ultrasound-guided vacuum or core biopsy were performed on seven lesions. One patient underwent surgical biopsy. Images of the breast diffuse optical tomography system were evaluated by comparing them with the radiological images.results: Ultrasound-guided biopsies or surgical biopsy revealed five ductal invasive carcinomas, one invasive lobular carcinoma, one adenosis and one papilloma. The other five lesions one hamartoma, one postoperative scar tissue, two cysts, one mastitis were diagnosed by ultrasound, MRI and/or mammography. Malignant or benign tumors and mastitis had higher contrast than normal breast tissue. Hamartoma, cysts and scar tissue produced no contrast when compared with the normal breast tissue. conclusion: We have demonstrated that the breast diffuse optical tomography system has the capacity to differentiate breast tumors from cyst and hamartoma

Keywords:

Laser, Breast, Tomography,

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