Kan Akımının Yerel Olarak Düzenlenmesinde Eritrositlerin Rolü

Amaç: Eritrositler basit yapılarından dolayı son yıllara kadar, fonksiyonları solunum gazlarının taşınmasıyla çevrelenmiş hücreler olarak değerlendirilmiştir. Oysa günümüzde, eritrositlerin bir çok hücre içi sinyal yolağına sahip olduğu ve dolaşım sisteminde hücrelerin karşılaştıkları mekanik kuvvetlerin etkisinde bu yolakların bir kısmının aktive olduğu bilinmektedir. Aktive olan bu yolaklar sonucu açığa çıkan bazı vazoaktif ürünlerin ise dolaşımın yerel düzenlenmesinde rolü olabileceği gösterilmiştir. Gereç ve Yöntemler: Derleme makalemizde eritrositlerden farklı koşullarda salgılanan vazoaktif ajanların yerel kan akımını düzenlenmesinde rol aldığını gösteren çalışmalarımızın ayrıntıları yer almaktadır. Bulgular: Çalışmalarımızın sonuçları, eritrosit nitrik oksit sentaz NOS enziminin hücrelerin maruz kaldığı mekanik kuvvetlerin etkisiyle aktifleştiğini, hücrelerde nitrik oksit NO üretiminin arttığını ve bu NO’nun hücre dışına çıkarak damar düz kasında anlamlı bir gevşeme yanıtına neden olduğu ilk kez gösterilmiştir.Sonuç: Eritrositler vazoaktif ajanlar salgılayarak dolaşımın yerel düzenlenmesinde rol almaktadır

Anahtar Kelimeler:

Eritrosit, Yerel kan akımı, NOS

Role of Erythrocytes on Local Blood Flow Regulation

Objective: Erythrocytes are known as carriers of respiratory gasses, due to their simple structure. However, it is well known that erythrocytes have many intracellular signalling mechanisms that can be activated in response to mechanical forces. The vasoactive substances released from red blood cells as a result of these activated mechanisms have been shown to be effective in the regulation of local circulation. Material and Methods: In this review article, we present a summary of our research results demonstrating the effects of vasoactive substances released from erythrocytes under different conditions. Results: The results of our studies demonstrated for the first time that erythrocyte nitric oxide synthase NOS enzyme is activated by mechanical forces and nitric oxide NO production is increased in erythrocytes. This NO then diffuses to smooth muscle cells where it causes relaxation. Conclusion: Erythrocytes play a role in local blood flow regulation by releasing vasoactive substances

Keywords:

Erythrocyte Local blood flow , Set back, NOS,

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