D Vitamini’ne Genel Bir Bakış

D vitamini yağda çözünen bir vitamin olup güneş ışığına cevap olarak sentezlenir. Aktif form 1, 25-(OH) 2D'dir. Kemik sağlığı, serum kalsiyum ve fosfor düzeyleri üzerinde önemli bir rol oynar. Sonepidemiyolojik çalışmalar düşük D vitamini düzeyleri ve birçok hastalık arasındaki ilişkiyi göz önünesermiştir. Düşük D vitamini düzeyleri erişkinlerde osteomalazi, otoimmün ve bulaşıcı hastalıklar,diabetes mellitus, artmış düşme ve kırık riski, kanser, hipertansiyon ve kardiyovasküler hastalıklar ileilişkilidir. Burada D vitamini fizyolojisi, metabolizması, eksikliği ve takviye için yeni öneriler literatürdeyayınlanan yeni bulgular dikkate alınarak gözden geçirilmiştir.

Overview of Vitamin D

Vitamin D, a fat-soluble vitamin, synthesised in response to sunlight. The active form is 1, 25-(OH)2D. It plays an important role in bone health, serum calcium and phosphate levels. Recent epidemiologic studies have observed relationships between low vitamin D levels and multiple disease states. Low vitamin D levels are associated with osteomalacia in adults, autoimmune and infectious diseases, diabetes mellitus, increased risk of fall and fractures, cancer, hypertension and cardiovascular diseases. Here vitamin D physiology, metabolism, deficiency and new recommendations for supplementation are reviewed by taking into consideration new findings published in the literature.

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