Akciğer Tüberkülozlu Hastaların Bronkoalveolar Lavajında İL-12, İFN-? ve sİL-2 Düzeyleri

Amaç: Çalışmamızda lokal immün cevabı yansıttığı düşünülen sitokin seviyelerini İL-12, İFN-γ ve sİL-2 bronkoalveolar lavaj sıvısında ölçerek balgamda yayma negatif saptanan hastalar ile balgam yayması pozitif olan hastaları karşılaştırmayı amaçladık. Gereç ve Yöntemler: Çalışma retrospektif olarak dizayn edildi. Çalışmaya Ekim 1998-Şubat 1999 arasında Yedikule Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi’nde tetkik ve tedavi edilen 24 tüberküloz hastası alındı. Kontrol grubu olarak diğer nedenlerle bronkoskopi yapılmış olan akciğer malignitesi veya tüberkülozu olmayan 15 hasta alındı. Bulgular: Hasta ve kontrol grupları İL-12, İFN-γ ve sİL-2 düzeyleri açısından karşılaştırıldığında İL-12 ve İFN-γ düzeylerinin anlamlı şekilde farklı olduğu tespit edildi sırasıyla p: 0,02 ve p

Anahtar Kelimeler:

Bronkoalveolar lavaj, İnterferon, İnterlökinler, Tüberküloz

IL-12, IFN-γ and sIL-2 Levels in Bronchoalveolar Lavage of Patients with Pulmonary Tuberculosis

Objective: We aimed to compare cytokine levels IL-12, IFN-γ and IL-2 , thought to reflect local immunologic response, in sputum smear positive and negative patients by measuring them in bronchoalveolar lavage fluid in this study.Material and Methods: The study had a retrospective design. A total of 24 tuberculosis patients who were examined and treated at Yedikule Chest Diseases and Chest Surgery Training and Research Hospital between October 1998 and February 1999 were included. Patients without pulmonary malignancy and tuberculosis who had undergone bronchoscopy for other reasons were included as the control group.Results: When the IL-12, IFN-γ and sIL-2 levels were compared in the patient and control groups, the IL-12 and IFN-γ levels were found to show a significant difference p: 0.02 and p

Keywords:

Bronchoalveolar lavage, Interferon, Interleukins, Tuberculosis,

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