MUSTAFA ÇELİK, Sezgin VATANSEVER, Altay KANDEMİR, Belkıs ÜNSAL

The utility of M30 and M65 antigen concentration levels for predicting degree of hepatic injury in patients with chronic hepatitis B infection

Background and Aims: We aimed to determine the utility of M30 and M65 antigen concentration levels for predicting hepatic injury in chronic hepatitis B disease. Materials and Methods: This study compared concentration levels of M30 and M65 antigens between patients with hepatitis B e-antigen negative chronic hepatitis B and healthy subjects. Furthermore, the correlations between either M30 or M65 antigen levels and aspartate aminotransferase, alanine aminotransferase, HBV-DNA, histological activity index and fibrosis were evaluated in the patient group. Results: A total of 81 subjects were included in the study; 50 patients with HBeAg negative chronic hepatitis B and 31 healthy subjects. The concentration of the M30 antigen was significantly higher in the chronic hepatitis B patient group than in the healthy subject group (p 0.05). Correlation analysis performed in the patient group revealed a significant correlation between M30 antigen concentration levels and aspartate aminotransferase levels (r: 0.207, p

Kronik hepatit B enfeksiyonununda hepatik hasar düzeyinin öngörülmesinde M30 ve M65 antijen düzeylerinin etkinliği

Giriş ve Amaç: Tüm hepatit türlerinde inflamatuvar olay nekroz ve apopitozu içeren farklı mekanizmalar ile hepatosit ölümüne sebep olur. M30-antijen apoptozis esnasında kaspazlar tarafından parçalanmış CK18 düzeylerini ölçmede, M65-antijen ise nekroza giden hücrelerden salgılanan total CK18 düzeylerini ölçmede kullanılır. Bu iki marker’ın kronik hepatit B enfeksiyonunda kullanımı ile ilgili sınırlı sayıda çalışma mevcuttur. Biz bu çalışmada M30 ve M65 antijen düzeylerinin, kronik hepatit B hastalığında karaciğer hasarını göstermede kullanılabilir olup olmadığını göstermeyi amaçladık. Gereç ve Yöntem: Bu çalışmada, Katip Çelebi Üniversitesi, İzmir Atatürk Eğitim ve Araştırma Hastanesi, Gastroenteroloji polikliniğine başvuran kronik hepatit B enfeksiyonlu hastalar ve sağlıklı kontrol grubunda, M30 ve M65 antijen düzeyleri ölçüldü ve çalışma sonunda elde edilen veriler karşılaştırıldı. Kronik aktif hepatit B enfeksiyonlu hastalarda ve sağlıklı kontrol grubunda M30 ve M65 antijen düzeyleri karşılaştırıldı. Ayrıca hasta grupta M30-M65 düzeyleri ile aspartat aminotransferaz, alanin aminotransferaz, hepatit B virus DNA, histoloji aktivite indeksi ve fibrozis düzeyleri arasındaki ilişki değerlendirildi. Bulgular: Çalışmaya 50 kronik aktif hepatit B hastası ve 31 sağlıklı kontrol olmak üzere toplam 81 hasta alındı. Hepatit B hasta grubunda M30-antijen düzeyi kontrol grubuna göre anlamlı düzeyde yüksek bulundu (p0.05). Hasta grupta yapılan korelasyon analizinde M30-antijen ile aspartat aminotransferaz arasında (r:0.207, p

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