Hatime Arzu YAŞAR, Güngör UTKAN, Nuriye YILDIRIM, Berna ÖKSÜZOĞLU, İsa DEDE, Yüksel ÜRÜN, Hakan AKBULUT

Mide kanseri ve ABO kan grubu ilişkisi: çok merkezli, gözlemsel, vaka-kontrol çalışması

Giriş ve Amaç: Bu çalışmanın amacı, kan grupları ile mide kanseri riski arasındaki ilişkiyi araştırmaktır. Gereç ve Yöntem: Çok merkezli, gözlemsel, vaka-kontrol çalışmasına 2000-2016 yılları arasında mide kanseri tanısı ile takip edilen ve serolojik olarak ABO kan grubu belli olan hastalar dahil edildi. Kontrol grubu olarak ise Türk Kızılayı’na kan bağışında bulunan sağlıklı kişiler seçildi ve sağlıklı kişilerin kan gruplarına Türk Kızılayı’nın kayıtlarından ulaşıldı. İstatistiksel analizler için SPSS versiyon 13 kullanıldı. Bulgular: Mide kanseri tanısı olan grup ile kontrol grubu arasında kan grupları açısından dağılımlar istatistiksel olarak farklı idi. Mide kanseri tanısı olan hastalarda A kan grubu daha fazla görülmekteydi (p < 0.001). Gruplar O grubu, non-O grubu olarak sınıflandırıldığında; mide kanseri tanısı olan grupta hastaların %29’unda (n: 253) O grubu, %71’inde (n: 627) non-O grubu tespit edildi. Kontrol grubunda ise vakaların %34’ünde O grubu ve %66’sında non-O grubu saptandı. Mide kanseri tanısı olan hastalar ile kontrol grubu karşılaştırıldığında mide kanserli hastalarda O grubu dışı kan gruplarının daha fazla görüldüğü tespit edildi (p: 0.010). Sonuç: Bu çalışmada, daha önce farklı ülkelerde yapılmış çalışmalara benzer olarak ülkemizde de O dışı (özellikle A grubu) kan grubuna sahip olmak artmış mide kanseri riski ile ilişkili bulundu.

Anahtar Kelimeler:

Mide kanseri, ABO kan grubu, risk faktörleri

The relation between gastric cancer and ABO blood groups: multicenter, observational, case-control study

Background and Aims: To investigate the relationship between ABO blood groups and gastric cancer risk. Materials and Methods: Patients who were followed up with a diagnosis of gastric cancer between 2000 and 2016 and whose ABO blood group was determined serologically were included in the multicenter, observational, case-control study. As the control group, healthy people who donated blood to the Turkish Red Crescent were selected and the blood groups of the healthy people were obtained from the records of the Turkish Red Crescent. SPSS version 13 was used for statistical analysis. Results: The distributions in terms of blood groups were statistically different between the group diagnosed with gastric cancer and the control group. A blood group was more common in patients with gastric cancer (p < 0.001). When blood groups classified as O group and non-O group; in the group diagnosed with gastric cancer, 29% (n: 253) of the patients were O group, 71% (n: 627) were non-O group; in the control group, O group was detected in 34% and non-O group was detected in 66% of the cases. When patients with gastric cancer and the control group were compared, it was found that non-O blood groups were more common in patients with gastric cancer (p: 0.010). Conclusion: In this study, having non-O (especially group A) blood group in our country was found to be associated with an increased risk of gastric cancer, similar to previous studies in different countries.

Keywords:

Gastric cancer, ABO blood group, risk factors,

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1. Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018;68:394-424.
2. Luo G, Zhang Y, Guo P, et al. Global patterns and trends in stomach cancer incidence: Age, period and birth cohort analysis. Int J Cancer 2017;141:1333-44.
3. Yalcin S. Gastric cancer in Turkey-a bridge between west and East. Gastrointest Cancer Res 2009;3:29-32.
4. Plummer M, Franceschi S, Vignat J, et al. Global burden of gastric cancer attributable to Helicobacter pylori. Int J Cancer 2015;136:487-90.
5. Brown ES. Distribution of the ABO and Rhesus (D) Blood Groups in the North of Scotland. Heredity (Edinb) 1965;20:289-303.
6. Hosoi E. Biological and clinical aspects of ABO blood group system. J Med Invest 2008;55:174-82.
7. Calafell F, Roubinet F, Ramirez-Soriano A, et al. Evolutionary dynamics of the human ABO gene. Hum Genet 2008;124:123-35.
8. Ewald DR, Sumner SC. Blood type biochemistry and human disease. Wiley Interdiscip Rev Syst Biol Med 2016;8:517-35.
9. Lotz RC, Welter CDS, Ramos SA, et al. ABO blood group system and occurrence of ischemic stroke. Arq Neuropsiquiatr 2021;79:1070-5.
10. Chen Z, Yang SH, Xu H, Li JJ. ABO blood group system and the coronary artery disease: an updated systematic review and meta-analysis. Sci Rep 2016;6:23250.
11. Liu F, Zhang Q, Rao L, Song J. Relationship between ABO blood group and risk of venous thrombosis in cancer patients with peripherally inserted central catheters: A protocol for systematic review and meta-analysis. Medicine (Baltimore) 2020;99:e23091.
12. Alexander KS, Zakai NA, Gillett S, et al. ABO blood type, factor VIII, and incident cognitive impairment in the REGARDS cohort. Neurology 2014;83:1271-6.
13. Yang H, Yan J. A systematic review of prognosis of ABO blood group and rhesus factor on outcomes in patients with bladder cancer. Medicine (Baltimore) 2022;101:e30893.
14. Yamamoto F, Cid E, Yamamoto M, Blancher A. ABO research in the modern era of genomics. Transfus Med Rev 2012;26:103-18.
15. Miao SY, Zhou W, Chen L, Liu XA. Influence of ABO blood group and Rhesus factor on breast cancer risk: a meta-analysis of 9665 breast cancer patients and 244,768 controls. Asia Pac J Clin Oncol 2014;10:101-8.
16. Li X, Xu H, Gao P. ABO Blood Group and Diabetes Mellitus Influence the Risk for Pancreatic Cancer in a Population from China. Med Sci Monit 2018;24:9392-8.
17. Urun Y, Utkan G, Cangir AK, et al. Association of ABO blood group and risk of lung cancer in a multicenter study in Turkey. Asian Pac J Cancer Prev 2013;14:2801-3.
18. Yang H, Zeng X, Zhang Y, et al. Influence of ABO blood group on susceptibility to different pathological types of lung cancer: a retrospective study. World J Surg Oncol 2022;20:379.
19. Karaoglan BB, Akyol C, Unal AE, et al. Relationship Between ABO Blood Group and Microsatellite Instability in Colorectal Cancer: A Retrospective Single-Center Study. J Gastrointest Cancer 2023 Jul 7. Epub ahead of print.
20. Qiu MZ, Zhang DS, Ruan DY, et al. A relationship between ABO blood groups and clinicopathologic characteristics of patients with gastric adenocarcinoma in China. Med Oncol 2011;28(Suppl 1):S268-73.
21. Aird I, Bentall HH, Roberts JA. A relationship between cancer of stomach and the ABO blood groups. Br Med J 1953;1:799-801.
22. Edgren G, Hjalgrim H, Rostgaard K, et al. Risk of gastric cancer and peptic ulcers in relation to ABO blood type: a cohort study. Am J Epidemiol 2010;172:1280-5.
23. Vasan SK, Hwang J, Rostgaard K, et al. ABO blood group and risk of cancer: A register-based cohort study of 1.6 million blood donors. Cancer Epidemiol 2016;44:40-3.
24. Hakomori S. Antigen structure and genetic basis of histo-blood groups A, B and O: their changes associated with human cancer. Biochim Biophys Acta 1999;1473:247-66.
25. Cui H, Qu Y, Zhang L, et al. Epidemiological and genetic evidence for the relationship between ABO blood group and human cancer. Int J Cancer 2023;153:320-30.
26. de Oliveira IA, Corvelo TCO. ABH and Lewis blood group systems and their relation to diagnosis and risk of Helicobacter pylori infection. Microb Pathog 2021;152:104653.