Kronik anal fissür için anal Botulinium toksin enjeksiyonu: 224 hastadan oluşan retrospektif bir kohortta etkinlik ve güvenlik analizi

Giriş ve Amaç: Anal Botulinium toksin tedavisi uygulanan kronik anal fissürlü hastada enjeksiyon bölgelerinin sayısı ile iyileşme sonuçları arasındaki ilişkiyi değerlendirmektir. Gereç ve Yöntem: Ocak 2012 ve Mart 2023 tarihleri arasında anal Botulinium toksin tedavisi uygulanan 224 hasta kaydı retrospektif olarak analiz edildi. Hastalar enjeksiyon bölgelerinin sayısına göre üç gruba ayrıldı: Grup A (iki enjeksiyon bölgesi, n = 34), Grup B (üç enjeksiyon bölgesi, n = 109) ve Grup C (dört enjeksiyon bölgesi, n = 81). Her enjeksiyonda 20 IU Botulinium toksin uygulanmıştı. İyileşme sonuçları yara iyileşmesi ve semptomların giderilmesi olarak 15, 30 ve 90. günde değerlendirilmiştir. Demografik bilgiler, tedavi ayrıntıları, iyileşme sonuçları ve tedaviye ilişkin olumsuz olaylar kaydedildi. Bulgular: Cox regresyon analizi, enjeksiyon bölgesi sayısı ile iyileşme sonuçları arasında anlamlı bir ilişki olduğunu ortaya koydu. Ameliyat sonrası her üç zaman noktasında da, ikiden fazla bölgede tedavi edilen hastalar (Grup C), iki bölgede tedavi edilen hastalara (Grup A) kıyasla daha yüksek iyileşme seviyeleri bildirmiştir. Sonuç: Kronik anal fissürü olan hastalarda anal Botulinium toksin ile tedavi edilen enjeksiyon bölgelerinin sayısı ile iyileşme sonuçları arasında ilişki vardır. Enjeksiyon bölgelerinin sayısının artması hem yara iyileşmesini hem de semptomların azalmasını arttırmaktadır.

Anahtar Kelimeler:

Enjeksiyon bölgesi sayıları, anal fissür, Botulinium toksini

Anal Botulinium toxin injection for chronic anal fissure: Efficacy and safety analysis in a retrospective cohort of 224 patients

Backgorund and Aims: The aim of this retrospective study is to evaluate the relationship between the number of injection sites and healing outcomes in 224 patients with chronic anal fissure who underwent anal Botulinum toxin treatment. Materials and Methods: The medical records of 224 patients who received anal Botulinum toxin treatment for chronic anal fissure were retrospectively analyzed. Patients were categorized into three groups based on the number of injection sites: Group A (two injection sites, n = 34), Group B (three injection sites, n = 109), and Group C (four injection sites, n = 81). Each injection contains 20 IU of Botulinum toxin. Healing outcomes, pain reduction, wound healing, and symptom resolution were evaluated. A comprehensive analysis of patient records and clinical data was performed. Demographic information, treatment details, healing outcomes, and adverse events were assessed. Results: Cox regression analysis revealed a significant association between the number of injection sites and healing outcomes. At all three post-operative time points, patients treated at multiple sites (Group C) reported higher recovery levels compared to patients treated at two sites (Group A). Conclusion: This study demonstrated a significant relationship between the number of injection sites treated with anal Botulinum toxin and healing outcomes in patients with chronic anal fissures. These findings highlight the importance of considering the number of injection sites. The study contributes to the understanding of anal Botulinum toxin treatment for chronic anal fissure, emphasizing its potential to improve patient care and overall quality of life.

Keywords:

Botulinum toxin anal fissure, injection site numbers, healing,

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