Arife Zühal DEĞİRMENCİOĞLU, YÜKSEL SEÇKİN

Sirozlu hastalarda Child-Pugh evresine göre Hepatit B Virüs DNA seviyeleri

Amaç: Hepatit B virüsü nedeniyle siroz gelişen hastalarda Child-Pugh evresine göre HBV DNA düzeylerini karşılaştırmak. Gereç ve Yöntem: Retrospektif olarak yapılan bu çalışmaya hepatit B enfeksiyonu nedeniyle yeni siroz tanısı alan hastalar dahil edildi. Hepatit B virus DNA, albümin, bilirübin ve uluslararası normalleştirilmiş oran düzeyleri Child-Pugh Skorlarına göre karşılaştırıldı. Bulgular: Çalışmaya ortalama yaşları 52.22±9.42 olan 90 hasta (60 erkek, 30 kadın) dahil edildi. Her grup 30 hastadan oluşuyordu. Hepatit DNA seviyesi, Grup A'da Grup B ve C'ye kıyasla anlamlı derecede düşüktü (p=0.031). Gruplar arasında Child-Pugh skorları, albümin, bilirübin ve uluslararası normalleştirilmiş oran düzeyleri açısından anlamlı fark bulundu (p=0.0001). Grup B ve C’de albümin düzeyleri daha düşüktü ve uluslararası normalleştirilmiş oran düzeyleri daha yüksekti (p <0.05). Asit ve ensefalopati 42 (%46,7) ve 79 (%87,8) hastada tespit edildi. C grubunda hem asit hem de ensefalopati daha sık görüldü. Sonuç: Hepatit B enfeksiyonu nedeniyle HBV DNA seviyesi sirozun erken evrelerinde belirgin olarak daha düşüktü ve albümin ve bilirübin düzeyleri nispeten normaldi. Ancak, kronik hepatit B'nin sonraki evrelerinde (Child-Pugh B ve C) asit ve ensefalopati daha sıktır, bilirübin ve hepatit B düzeyleri artmakta ve albümin seviyeleri azalmaktadır.

Anahtar Kelimeler:

Hepatit B virüsü DNA, siroz, karaciğer yetmezliği, albümin, bilirübin, Child-Pugh Skoru

Hepatitis B Virus DNA levels according to the Child-Pugh stage in patients with cirrhosis

Objective: To compare hepatitis B virus DNA levels according to Child-Pugh stage in patients who developed cirrhosis due to hepatitis B virus. Materials and Methods: This study was conducted as retrospectively. Patients who were newly diagnosed with cirrhosis due to hepatitis B virus infection were included. hepatitis B virus DNA, albumin, bilirubin, and international normalization rate levels were compared according to the Child-Pugh Scores. Results: A total of 90 patients (60 males, 30 females) with a mean age of 52.22±9.42 years were included in this study. Each group consisted of 30 patients. Hepatitis B virus DNA level was significantly lower in the Group A compared with the Group B and C (p=0.031). A significant difference was observed between the groups in terms of Child-Pugh scores, albumin, bilirubin, and international normalization rate levels (all p=0.0001). Albumin levels were lower and international normalization rate levels were higher in the Group B and C (all p<0.05). Ascites and encephalopathy were detected in 42 (%46,7) and 79 (87,8) patients, respectively. Both ascites and encephalopathy were more common in the Group C. Conclusion: Hepatitis B virus DNA level was significantly lower and albumin and bilirubin levels were relatively normal in the early stages of cirrhosis due to hepatitis B virus infection. By contrast, ascites and encephalopathy were more common, bilirubin and international normalization rate levels were elevated, and albumin levels were lower in the later stages (Child-Pugh B and C) of chronic hepatitis B.

Keywords:

Hepatitis B virus DNA, cirrhosis, liver failure, albumin, bilirubin, Child-Pugh Score,

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