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Helicobacter pylori kolonizasyon yoğunluğu çölyak hastalığının gelişmesinde önemli rol oynayabilir

Giriş ve Amaç: Bu çalışmanın amacı çölyak hastalığı ile Helicobacter pylori enfeksiyonu arasındaki ilişkiyi araştırmak ve modifiye Marsh skoruna göre erişkinlerde çölyak hastalığı ile Helicobacter pylori enfeksiyonunun şiddetini karşılaştırmaktır. Gereç ve Yöntem: Bu çalışmaya üçüncü basamak bir hastanede çeşitli nedenlerle endoskopi yapılan çölyak hastalığı olmayan 148 çölyak hastası ve 240 kontrol hastası dahil edildi. Hastaların yaş, cinsiyet, endoskopi endikasyonları, tanımlayıcı özellikleri, şikayetleri, serolojik, endoskopik ve histopatolojik bulguları kaydedildi ve analiz edildi. Bulgular: Çölyak hastalarında Helicobacter pylori kolonizasyonu %43.9, kontrol grubunda %57.5 idi (p = 0.009). Helicobacter pylori pozitiflik oranı Marsh 2, 3A, 3B, 3C gruplarında anlamlı olarak daha düşüktü (p = 0.04). Pearson korelasyon analizi, Helicobacter pylori'nin şiddeti ile çölyak hastalığı arasında zayıf ancak anlamlı negatif bir ilişki ortaya koydu (r = -.109, p = 0.031). Marsh skoru arttıkça Helicobacter pylori derecesi düştü. Sonuç: Mevcut çalışma, çölyak hastalığı olan erişkinlerde kontrol hastalarına göre Helicobacter pylori enfeksiyonu insidansının daha düşük olduğunu ve Helicobacter pylori kolonizasyon yoğunluğunun çölyak hastalarında daha hafif duodenal lezyonlarla ilişkili olduğunu göstermiştir. Helicobacter pylori kolonizasyonu, çölyak hastalığının gelişiminde koruyucu bir role sahip olabilir.

Anahtar Kelimeler:

Çölyak hastalığı, endoskopik bulgular, Helicobacter pylori, Marsh skoru

Helicobacter pylori colonization density may have an important role in the development of Celiac disease

Background and Aims: The aim of this study was to investigate the relationship between celiac disease and Helicobacter pylori infection and to compare the severity of celiac disease and Helicobacter pylori infection in adults according to the modified Marsh score. Materials and Methods: This study included 148 patients with celiac disease and 240 control patients without celiac disease who underwent endoscopy for various reasons in a tertiary hospital. Age, gender, endoscopy indications, descriptive characteristics, complaints, serological, endoscopic and histopathological findings of the patients were recorded and analyzed. Results: Helicobacter pylori colonization in the celiac disease patients was 43.9% and in control group was 57.5% (p = 0.009). Helicobacter pylori positivity rate was significantly lower in Marsh 2, 3A, 3B, 3C groups ( p = 0.04). Pearson correlation analysis revealed a significant but weak negative relationship between the severity of Helicobacter pylori and celiac disease (r = -.109, p = 0.031). When Marsh score was increasing, Helicobacter pylori grade decreased. Conclusion: The current study indicated that the incidence of Helicobacter pylori infection was lower in adults with celiac disease compared to control patients, and Helicobacter pylori colonization density was associated with milder duodenal lesions in celiac patients. Helicobacter pylori colonization may have a protective role in the development of celiac disease.

Keywords:

Celiac disease, endoscopic findings, Helicobacter pylori, Marsh score,

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