Mustafa KUZEYTEMİZ

COVID-19 lu Genç Hipertansif Hastalarda, Hipertansiyon Tek Başına Mortaliteyi Artırır Mı? 100 Hasta ile Tek Merkez Retrospektif Çalışma

Amaç: Hipertansiyonun, tek başına COVID-19 bulgularının şiddeti ve COVID-19 kaynaklı mortalite için bağımsız bir risk faktörü olup olmadığı hala açık değildir. Bu çalışmada, önceden hipertansiyonu olan ve olmayan COVID-19 hastalarını klinik özellikler ve laboratuvar ölçümleri açısından karşılaştırarak hipertansiyonun tek başına COVID-19 seyrine etkisini araştırmak amaçlandı.Araçlar ve Yöntem: Önceden hipertansiyonu olan ancak başka hiçbir kronik hastalığı olmayan 45 yaşından küçük 50 COVID-19 hastası, 50 normotansif COVID-19 hastasıyla karşılaştırıldı. Tüm hastalar aynı tedavi protokolünü aldı. Gruplar arasında semptomların sıklığı, inflamatuvar belirteçlerin kan düzeyleri, hastanede kalış süresi, yoğun bakım ünitesi(YBÜ) gereksinimi ve ölüm oranları karşılaştırıldı.Bulgular: Hipertansif grupta normotansif grupla karşılaştırıldığında tepe lökosit sayısı (8,1±2,7x103/mm3 vs. 6,9±1,9x103/mm3, p=0.012), tepe C-reaktif protein (52.7±9.7mg/L vs. 18.9±3.7mg/L, p=0.024), ve tepe eritrosit sedimentasyon hızı (55.5±5.7 mm/h, vs. 33.4±5.1 mm/h, p<0.01) anlamlı derecede yüksekti ( tüm değerler sırasıyla). Hastanede yatiş süresi hipertansif grupta normotansif gruba göre önemli oranda uzundu (hipertansif grupta11±2.4 gün; normotansif grupta 9.1±2.2 gün, p=0.001).Sonuç: Hipertansiyonu olan COVID-19 hastaları, hipertansiyonu olmayan COVID-19 hastalarına kıyasla daha yüksek seviyelerde inflamatuar belirteçlere, daha yüksek troponin seviyelerine ve daha uzun hastanede kalış sürelerine sahiptir. Görüldüğüne göre hipertansif hastalar normotansif olanlara göre COVID-19 enfeksiyonunu daha şiddetli geçirme eğilimindedir.

Anahtar Kelimeler:

COVİD-19, , SARS-CoV-2, , mortalite, , hipertansiyon.

Does Hypertension Alone Increase Mortality in Young Hypertensive Patients Having COVID-19? Single Center Retrospective Study of 100 Patients

Purpose: Whether hypertension is an independent risk factor for the severity of COVID-19 symptoms and COVID-19 mortality is still unclear. In this study, it was aimed to investigate the effect of hypertension independently in the course of COVID-19 by comparing clinical characteristics and laboratory measurements in COVID-19 patients with and without preexisting hypertension.Materials and Methods: Fifty COVID-19 patients under the age of 45 with preexisting hypertension without accompanying chronic diseases were compared with 50 normotensive COVID-19 patients. All patients received the same treatment protocol. The frequency of symptoms, blood levels of inflammatory markers, length of hospital stay, intensive care unit (ICU) requirement, and mortality rates were compared between the groups.Results: Peak leukocyte count (8.1±2.7 x 103/mm3 vs. 6.9±1.9x103/mm3, p=0.012), peak C-reactive protein (52.7±9.7mg/L vs. 18.9±3.7 mg/L, p=0.024), and peak erythrocyte sedimentation rate (ESR) (55.5±5.7 mm/h, vs. 33.4±5.1 mm/h, p<0.01) were significantly higher in hypertensive patients compared to normotensive ones (all values respectively). Hospital stay duration was significantly longer in hypertensive patients than the normortensive ones. (hypertensive group 11±2.4 days; normotensive group 9.1±2.2 days, p=0.001).Conclusions: COVID-19 patients having hypertension have higher levels of inflammatory markers, higher levels of troponin, and longer hospital stay compared to COVID-19 subjects without hypertension. It appears that hypertensive patients tend to have a more severe COVID-19 infection than normotensive patients.

Keywords:

COVİD19, , SARSCoV-2, , mortality, , hypertension.,

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