Halil ÇETİNGÖK, Gülay EREN, Gülsüm Oya HERGÜNSEL, Dilek ALTUN, Zafer ÇUKUROVA

Yoğun bakım ünitesinde magnezyum'u kritik hastalar için sedasyon amaçlı kullanabilir miyiz? Diğer sedatifler kadar etkili mi?

Amaç: Bu prospektif randomize çalışmada, midazolama eklenen magnezyumun hemodinami, T-parçasına geçiş süresi, mekanik ventilasyon süresi ile BIS monitorizasyonu ve sedasyon ölçekleri kullanılarak ek sedatif analjezik gereksinimi üzerine etkisini araştırmayı amaçladık. Gereç ve Yöntem: Yoğun bakım ünitesinde mekanik ventilasyon desteği alan 50 hasta rasgele olarak iki gruba ayrıldı. Grup I, 0.03-0.3 mg/kg bolus yükleme dozu +0.03-02 mg/kg/saat midazolam infüzyonu aldı; Grup II, 30 dakikada. 2 gr bolus, 16 mg/24 saat magnezyum infüzyonu +0.03-02 mg/kg/saat midazolam infüzyonu aldı. BIS seviyeleri ve sedasyon seviyeleri sürekli olarak monitörize edildi. Bulgular: Grup I’de mekanik ventilasyonun süresi grup II’den daha uzundu (sırasıyla 31±12 saat; 19±11 saat; p

Can we use magnesium for sedation in the intensive care unit for critically ill patients: Is it as effective as other sedatives?

Objectives: The aim of this prospective, randomized study was to investigate the effect of magnesium added to midazolamon the hemodynamics, transition time to a T-piece, mechanical ventilation duration, additional sedative-analgesic requirementusing bispectral index (BIS) monitorization and sedation scales.Methods: Fifty critically ill patients receiving mechanical ventilation support in the intensive care unit were randomly assignedto 2 groups. Group I received a 0.03-0.3 mg/kg bolus loading dose+0.03-02 mg/kg/hour midazolam infusion; Group IIreceived a 2 g bolus at 30 minutes, 16 mg/24-hour magnesium infusion+0.03-02 mg/kg/hour midazolam infusion. BIS levelsand sedation levels were continuously monitored.Results: The duration of mechanical ventilation in Group I was longer than that of Group II (31±12 hours, 19±11 hours, respectively;p

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