Esra ÇAĞIRAN, CAN EYİGÖR, Bahar SEZER, Meltem UYAR

Preemptive analgesic efficacy of dexketoprofen trometamol on impacted third molar surgery

Amaç: Bu çalışmada, intravenöz (IV) deksketoprofen trometamolün (DT) gömük üçüncü molar diş cerrahisindeki preemptif anal- jezik etkinliğinin plasebo grubuyla karşılaştırılması amaçlandı. Gereç ve Yöntem: İki taraflı gömük diş çekimi yapılacak 18 yaş üzerinde 20 hasta ileriye dönük, randomize, plasebo kontrollü çalışmaya alındı. Bir diş çekiminde 50 mg DT alan hastaya diğer diş çekiminde plasebo uygulandı. Toplam 40 gözlem yapıldı. Ağrı skorları cerrahi sonrası Sözel Ağrı Skalası (VRS) ile değerlendirildi. Ayrıca ilk analjezik alma zamanı, ek analjezik ihtiyacı olan hastalar, hasta ve hekim memnuniyeti, yan etkiler kaydedildi. Bulgular: İlk 12 saat içinde VRS skoru DT grubunda plasebo grubuna göre anlamlı olarak daha düşüktü (p

Gömülü üçüncü molar diş cerrahisinde deksketoprofen trometamol\'un preemptif analjezik etkinliği

Objective: The aim of this study was to compare the pre-emptive analgesic efficacy of intravenous (IV) dexketoprofen tro- metamol (DT) and placebo, following impacted mandibular third molar surgery. Methods: Twenty patients over 18 year old who needed bilateral lower third molar extractions were included in this prospec- tive, randomized and placebo-controlled clinical trial. Patients whom had taken DT 50 mg of before their one extraction, took placebo before their other extraction which had been performed on the opposite side. A total of 40 observations were made. Pain scores were evaluated with a Verbal Rating Scale (VRS) after surgery. Moreover; the time to first analgesic requirement use, additional analgesic need of patients, patient and doctor satisfaction, side effects were also determined. Results: During the first 12 hours, the VRS values in DT group were significantly lower than those of placebo group patients (p<0.05). In placebo group, the time to first analgesic requirement use was significantly earlier than that of patients in DT group (p<0.05). Additional analgesic need of placebo group were significantly greater, when compared with the analgesic need of DT group patients (p<0.05). Among the DT group patients, patient and physician satisfaction was greater, which was statistically significant (p<0.05). Conclusion: Preemptive use of IV DT is more effective than placebo for using as preemptive analgesia for acute postoperative pain control in patients underwent removal of an impacted mandibular third molar surgery.

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