Stent-içi restenozu öngörmede serum TGF-β düzeylerinin etkinliği

Amaç: Stent-içi restenoz (SİR), stent implantasyonu sonrası erken ve geç dönem morbiditenin en önemli nedenlerinden birisidir. Biz bu çalışmada serum dönüştürücü büyüme faktörü-β (TGF-β) düzeyinin gelişebilecek SİR’i ön gördürüp gördürmeyeceğini araştırmayı planladık. Gereç ve Yöntem: Daha önce peruktan koroner girişim (PKG) uygulanmış ve herhangi bir endikasyonla koroner anjiografi (KAG) planlanmış toplam 82 hasta çalışmaya dahil edildi. SİR; stent içinde ≥%50 daralma olması şeklinde tanımlandı. 34 hastada restenoz saptanırken 48 hastada anjiografik olarak kritik lezyon saptanmadı. Tüm hastalarda plazma TGF- β düzeyi ölçüldü. Bulgular: SİR ile TGF- β düzeyi arasında istatistiksel olarak anlamlı bir ilişki saptanmadı (p=0,754). Yapılan alt grup çok değişkenli regresyon analizinde hedef damar çapı ile SİR arasında negatif, sağ koroner arter lezyonları ile SİR arasında pozitif korelasyon saptandı. Sonuç: Bu çalışma herhangi bir zamanda bakılan TGF-β’nın SİR öngördürücü bir özelliği olmadığını ortaya koymuştur

Anahtar Kelimeler:

Stent-içi restenoz, TGF- β, Koroner arter hastalığı, Perkütan koroner girişim

The predictive value of plasma TGF-β levels in in-stent restenosis

Aim: In-stent restenosis (ISR) is one of the most important cause of both early and late morbidity in coronary artery disease (CAD). We planned to investigate whether this molecule could predict future ISR or not. Materials and Methods: 82 patients who has prior PCI history and is scheduled for coronary angiography for any reason is included in the study. ISR is defined as ≥%50 narrowing inside the stent. Plasma TGF- β levels are studied in all patients. Results: We found no significant correlation between ISR and TGF-β levels (p=0.754). In multivariate regression analysis there is a negative corelation between ISR and target vessel diameter, and positive corelation between ISR and right coronary artey (RCA) lesions. Conclusion: This study has shown that there is no attribute of TGF- β in predicting ISR.

Keywords:

In-stent restenosis, TGF-β, Coronary artery disease, Percutaneous coronary implantation,

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