Is there any association between ABO blood types and slow coronary flow?

Aim: Slow coronary flow (SCF) is defined as a microvascular disorder characterized by slow advance of the contrast material administered during angiography, despite absence of epicardial coronary artery occlusion and delayed opacification of distal vascular structures. Genetically inherited ABO blood types are presumed to play role in coronary artery disease. In this study, the relationship between SCF and ABO blood types was investigated.Methods: The study was designed as a retrospective study, and included 250 cases that underwent coronary angiography procedure in our center between 2016 January and 2018 December (one hundred and twenty five cases of SCF and 125 cases of normal coronary angiogram). ABO blood types were determined using standard agglutination techniques in both study groups. Blood types were compared between both subject groups. Results: The frequency of blood type A was increased among patients with SCF in comparison with control subjects (p<0.001). High density lipoprotein cholesterol was increased in SCF group (p<0.001). Triglyceride, , total cholesterol and low density lipoprotein cholesterol levels were increased in the SCF group when compared to controls (p=0.003, p<0.001, and p<0.001, respectively).

Anahtar Kelimeler:

ABO blood types, slow coronary flow, Cardiology

Is there any association between ABO blood types and slow coronary flow?

Amaç: Koroner yavaş akım (KYA), epikardiyal koroner arter tıkanıklığı olmamasına rağmen, anjiyografi sırasında uygulanan kontrast maddenin yavaş ilerlemesi ve distal vasküler yapıların gecikmeli opaklaşması ile karakterize bir mikrovasküler bozukluk olarak tanımlanmaktadır Genetik olarak taşınan ABO kan gruplarının koroner arter hastalığında rol oynadığı varsayılmaktadır. Bu çalışmada KYA ve ABO kan grupları arasındaki ilişki araştırıldı.Gereç ve yöntemler: Çalışma retrospektif bir çalışma olarak tasarlandı ve merkezimizde Ocak 2016 - Aralık 2018 tarihleri arasında koroner anjiyografi prosedürü uygulanan 250 vaka (125 KYA hastası ve 125 normal koroner anjiyogram vakası) çalışmaya dahil edildi. Her iki çalışma grubunda da ABO kan tipleri standart aglütinasyon teknikleri kullanılarak belirlendi. Her iki grup arasında kan tipleri karşılaştırıldı.Bulgular: KYA hastalarında A kan grubu sıklığı kontrol grubuna kıyasla artmıştı (p<0.001). Kontol grubunda yüksek dansiteli lipoprotein kolesterol artmıştı (p<0.001). Kontrol grubuna kıyasla trigliserit, total kolesterol ve düşük dansiteli lipoprotein kolesterol düzeyleri KYA grubunda artmıştı ( p =0.003, p<0.001, p<0.001, sırasıyla). Sonuç: Bu çalışma, A kan grubunun KYA için artmış bir risk olabileceğini ortaya koydu.

Keywords:

ABO kan grupları, koroner yavaş akım, kardiyoloji,

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