Ahmet AKTAŞ, Mustafa Asım GEDİKLİ, Ali SAHİN

Ailesel Akdeniz Ateşi hastalarının trigliserid/yüksek dansiteli lipoprotein oranına göre karşılaştırılması

Amaç: Bu çalışmada, Ailevi Akdeniz Ateşi (AAA) hastaları ve kontrol grubu arasında Trigliserit/HDL-Kolesterol oranlarını karşılaştırarak, AAA hastalığı ile kardiyovasküler risk arasında bir ilişki olup olmadığını göstermeyi amaçladık.Gereç ve Yöntem: Çalışmamıza 150 Ailevi Akdeniz Ateşi (AAA) hastası ve 18-65 yaş arası 150 kontrol grubu olmak üzere toplam 300 hasta dahil edildi. Hastaların trigliserid/HDL-Kolesterol oranları karşılaştırıldı.Bulgular: Trigliserid / HDL-Kolesterol oranı, kontrol grubuna göre AAA grubunda istatistiksel olarak anlamlı yüksek bulundu (p=0,026).Sonuç: AAA hastalarında Trigliserid/HDL-Kolesterol oranı, kardiyak riski göstermede ucuz, tekrarlanabilir bir prediktör olarak kullanılabilir.

Anahtar Kelimeler:

AAA, Trigliserid/HDL-Kolesterol oranı, kardiyak risk

Comparison of Familial Mediterranean Fever patients by triglyceride/high-density lipoprotein ratio

Aim: In this study, we aimed to show whether there is a relationship between FMF disease and cardiovascular risk by comparing Triglyceride/HDL-Cholesterol ratios between FMF patients and the control group.Materials and Methods: A total of 300 patients, including 150 Familial Mediterranean Fever (FMF) patients and 150 control groups aged 18-65, were included in our study. Triglyceride/HDL-Cholesterol ratios of the patients were compared.Results: Triglyceride/HDL-Cholesterol ratio was statistically significantly higher in the FMF group than the control group (p=0.026).Conclusion: In FMF patients, the Triglyceride/HDL-Cholesterol ratio can be used as an inexpensive, reproducible predictor in showing a cardiac risk.

Keywords:

FMF, Triglyceride/HDL-Cholesterol ratio, cardiac risk,

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Bayram M, Derin ME, Doğan HO, Asan G, Şahin M, Şahin A. High prolidase levels in patients with Familial Mediterranean Fever (FMF). Romanian Journal of Internal Medicine. 2020;58(1):27-33.
Kozan M, Ozan ZT, Demir V, Ede H. The relation of novel cardiovascular risk parameters in patients with familial Mediterranean fever. JRSM cardiovascular disease. 2019;8:2048004018823856.
Stojanovic KS, Hentgen V, Fellahi S, et al. Concordance between CRP and SAA in familial Mediterranean fever during attack-free period: a study of 218 patients. Clinical biochemistry. 2017;50(4-5):206-209.
Ishizuka T, Fujioka K, Tangiku M, et al. AB0988 clinical features and analysis of mefv gene in 31 patients with familial mediterranean fever (FMF). BMJ Publishing Group Ltd; 2020.
Köstek O, Takir M, Çalişkan M, Oğuz A. Assessment of cardiovascular findings in FMF related amyloid patients. Medeniyet Medical Journal. 2018;33(3):149-157.
Cromwell WC, Otvos JD, Keyes MJ, et al. LDL particle number and risk of future cardiovascular disease in the Framingham Offspring Study—implications for LDL management. Journal of clinical lipidology. 2007;1(6):583-592.
Ardahanli I, Celik M, Takir M. Relationship between Neutrophil/Lymphocyte Ratio and Cardiometabolic Values in Patients with Prediabetes.Glob. J. Endocrinol.2018;2(4):1-4.
Cooney M, Dudina A, De Bacquer D, et al. HDL cholesterol protects against cardiovascular disease in both genders, at all ages and at all levels of risk. Atherosclerosis. 2009;206(2):611-616.
Bittner V, Johnson BD, Zineh I, et al. The triglyceride/high-density lipoprotein cholesterol ratio predicts all-cause mortality in women with suspected myocardial ischemia: a report from the Women's Ischemia Syndrome Evaluation (WISE). American heart journal. 2009;157(3):548-555.
Edwards MK, Blaha MJ, Loprinzi PD. Atherogenic index of plasma and triglyceride/high-density lipoprotein cholesterol ratio predict mortality risk better than individual cholesterol risk factors, among an older adult population. Elsevier; 2017:680-681.
Çetin EHÖ, Cetin MS, Könte HC, et al. Trigliserit/HDL oranının, koroner arter hastalığı varlığını ve plak morfolojisini öngördürmedeki yeri. Turkish Journal of Clinics and Laboratory. 10(4):467-473.
Ozkurede V, Franchi L. Immunology in clinic review series; focus on autoinflammatory diseases: role of inflammasomes in autoinflammatory syndromes. Clinical & Experimental Immunology. 2012;167(3):382-390.
Salazar MR, Carbajal HA, Espeche WG, et al. Use of the plasma triglyceride/high-density lipoprotein cholesterol ratio to identify cardiovascular disease in hypertensive subjects. Journal of the American Society of Hypertension. 2014;8(10):724-731.
Masson W, Siniawski D, Lobo M, Molinero G, Huerín M. Association between triglyceride/HDL cholesterol ratio and carotid atherosclerosis in postmenopausal middle-aged women. Endocrinología y Nutrición (English Edition). 2016;63(7):327-332.
Prasad M, Sara JD, Widmer RJ, Lennon R, Lerman LO, Lerman A. Triglyceride and triglyceride/HDL (high density lipoprotein) ratio predict major adverse cardiovascular outcomes in women with non‐obstructive coronary artery disease. Journal of the American Heart Association. 2019;8(9):e009442.
Keles N, Aksu F, Aciksari G, et al. Is triglyceride/HDL ratio a reliable screening test for assessment of atherosclerotic risk in patients with chronic inflammatory disease? Northern clinics of Istanbul. 2016;3(1):39.
Murguía-Romero M, Jiménez-Flores JR, Sigrist-Flores SC, et al. Plasma triglyceride/HDL-cholesterol ratio, insulin resistance, and cardiometabolic risk in young adults. Journal of lipid research. 2013;54(10):2795-2799.
Motamed M, Nargesi AA, Heidari B, Mirmiranpour H, Esteghamati A, Nakhjavani M. Oxidized Low-Density Lipoprotein (ox-LDL) to LDL Ratio (ox-LDL/LDL) and ox-LDL to High-Density Lipoprotein Ratio (ox-LDL/HDL). Clinical laboratory. 2016;62(9):1609-1617.
Dogan C, Bayram Z, Karagoz A, et al. Is elevated triglyceride high density lipoprotein cholesterol ratio a risk factor that causes acute coronary syndrome to appear earlier? Clinical Study. 2019;770:775.