Çiğdem ÖZDİLEKCAN, Sevim TURANLI, Necla SONGÜR, Hüseyin ÇAKMAK

Farklı Sistem Tümörlerini Takiben Gelişen İkinci Primer Akciğer Kanserlerinin Analizi

AMAÇ: Bu çalışmada farklı sistem malignitelerine sekonder olarak gelişen akciğer tümörlerin klinik özellikleri ve primer tümörle olan ilişkilerinin araştırılması amaçlandı.YÖNTEMLER: 2002-2010 yılları arasında takipleri sırasında ikinci primer kanser tanısı alan otuz hasta çalışmaya dahil edildi. Hastalar, akciğer kanseri gelişme sürelerine göre senkron (n: 7 hasta, %16,7)ve metakron (N.23 Hasta, %83,3) grup olarak iki grupta değerlendirildi.BULGULAR: Hastaların %50sinde ilk 2.5 yıl içinde ikinci primer kanser saptandı. Hastaların çoğunluğunun (%43.3) akrabalarında ekstra pulmoner kanser öyküsü vardı. Akciğer kanseri tanısı konulan hastalardan %50sinde sigarayı bırakma, %30unda aktif içici ve %20sinde hiç sigara kullanmamış olma öyküsü vardı. Primer kanser ile ilgili yapılan tedaviye yanıt ve ikincil gelişen kanserin süresi arasında istatistiksel olarak anlamlı bir ilişki saptanmadı (p=0.36).Grupların tamamında sağ kalım süresi 24 ay senkron grupta, 12 ay metakron grupta belirlendi.SONUÇ: Primer hastalıktan sonra özellikle ilk 2.5 yıl içinde yakın takip ve hastalara sigara içiciliğinin bıraktırılmasının teşvik edilmesi önem taşımaktadır.

Anahtar Kelimeler:

Akciğer kanseri, ikinci primer; senkron; metakron

Analysis of Second Primary Lung Cancers Developed Following Different System Tumors

OBJECTIVE: This study aimed to investigate clinical characteristics and prognosis of secondarily developed lung tumors in the cases having different system malignancy and to evaluate the relationship with the primary tumor.METHODS: Between January 2002- December 2010 thirty patients diagnosed as second primary lung cancer have been included in the study. The patients were grouped according to lung cancer development time; synchronous group (n: 7 patients, 16.7%) and metachronous group (n: 23 patients, 83.3%). RESULTS: Second cancer was detected in 50% of the patients within the first 2.5 years. Majority of patients had extra pulmonary cancer history concerning their relatives (43.3%). The rate of quitting smoking among all patients before the diagnosis of lung cancer was 50 %, current smoker rate was 30 % and never smoker was 20%. There was no statistical relationship between the response to treatment of first cancer and the duration of cancer developed secondarily (p=0.36). The overall survival of groups was found 24 months (95% confidence interval: 18.30 months) and 12 months (95% confidence interval: 10-14 months) respectively for synchronous and metachronous groups. CONCLUSION: Close follow-up on pulmonary system especially within the first 2.5 years after primary disease and encouragement on quitting smoking is important.

Keywords:

Lung carcinoma, second primary; synchronous; metachronous,

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