Yeşim ŞENAYLI, Atilla ŞENAYLI

Conjugated Hyperbilirubinemia in a Neonate with Meconium lleus and Congenital Hypothyroidism

Mekonyum ileusu kistik fibrozisin eşsiz belirtisidir. Mekonyum ileus ile çeşitli birliktelikler, özellikle kistik fibrozis rapor edilmiştir; ancak hastamız kistik fibrozis ile beraber rapor edilen ve konjenital hipotiroidism ile konjuge hiperbiiirubinemiyi bulunduran ilk hastadır. Bu iki durumun mekanizmaları için detaylı açıklamalar bulunmaktadır; ancak literatür araştırması sonrasında muhtemel ortak mekanizma için bir açıklama bulunamamıştır. Bu durumun sadece birliktelik olduğu düşünülmüştür. Konjenital hipotiroidizm kistik fibrozis olan ve kojuge hiperbilirubinemi olan hastalarda göz ardı edilmemeli ve araştırılmalıdır.

Anahtar Kelimeler:

Mekonyum ileus, konjuge hiperbilirubinemi, çocuk, kistik fibrosis.

Mekonyum ileus ve Konjerıital Hipotroidizm Olan Bir Yenidoğanda Konjuge Hiperbilirubirıemi

Meconium ileus is a unique manifestation of cystic fibrosis. Different anomalies associated with meconium ileus, conse-quently in cystic fibrosis, were reported but our case was the first reported with congenital hypothyroidism demonstrating signi-ficant conjugated hyperbilirubinemia. There are detailed explanations about the mechanisms of these two entities but we found no possible common pathvvay for these diseases in the evaluation of the literatüre. We suggest that this unique formation may only be coexistence. Congenital hypothyroidism may be evaluated for the patients with cystic fibnosis when conjugated hyperbilirubinemia is detected.

Keywords:

Meconium ileus, conjugated hyperbilirubinemia, children, cystic fibrosis.,

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