Mustafa Çağrı SAYILIR, Bülent ERBİL, Mehmet Ali ASLANER, Mehmet Mahir ÖZMEN

Eser Elementler ile Diabetes Mellitus Komplikasyonları Arasındaki İlişki

Amaç: Glikoz metabolizmasında eser elementlerin çinko Zn , krom Cr , selenyum Se , demir Fe , bakır Cu ve vanadyum Va etkileri olduğu bilinmektedir. Bu çalışmanın amacı acil servise başvuran hastalarda eser element düzeyleri ile akut diabetes mellitus DM komplikasyonları arasındaki ilişkiyi tespit etmektir. Yöntemler: Bir üniversitesi hastanesi üçüncü basamak acil servisine 01 Ocak 2012 – 29 Şubat 2012 tarihleri arasında başvuran 18 yaş ve üzeri yeni DM tanısı konulan veya daha önceden DM tanısı olan hastalar aydınlatılmış onam alınarak çalışmaya dâhil edildi. Kontrol Grubu ise bilinen herhangi bir hastalığı ve ilaç kullanımı olmayan 18 yaş üstü sağlıklı bireylerden seçildi. Eser element düzeyleri ise atomik absorpsiyon spektrofotometrik yöntemle TQ X5 marka ICP-MS cihazı kullanılarak elde edildi. Eser element düzeyleri, hem DM ile sağlıklı kontrol grubu arasında hem de DM komplikasyonları olan hastalar ile sağlıklı kontrol grubu arasında karşılaştırıldı. Bulgular: Çalışmaya toplamda 249 124 kadın kişi alındı. 151 84 kadın kişi çalışma grubunu DM oluştururken 98’i 40 kadın kontrol grubunu oluşturdu. Acil servise başvuran diyabet hastalarının ölçülen eser element düzeyleri ile kontrol grubu karşılaştırıldığında ortalama değerlerde belirgin bir fark olmadığı tespit edildi p>0,05 . Akut diyabetik komplikasyonları olan diyabetik ketoasidoz, diyabetik ketoz ve hiperglisemi hastalar n=11 ile kontrol grubu karşılaştırıldığında da yine her iki grup arasında anlamlı fark bulunamadı p>0,05 . Sonuç: Yapılan araştırmalar eser elementlerin moleküler düzeyde glikoz metabolizmasındaki etkilerini göstermekle birlikte, çalışmamızda acil servise başvuran akut diyabetik komplikasyonları olan hastalarda bakılan eser element düzeylerinin Zn, Cr, Se, Fe, Cu ve Va sağlıklı bireylerle karşılaştırılması sonucunda aralarında anlamlı bir fark bulunamamıştır.

The Relationship Between Trace Elements and Complications of Diabetes Mellitus

Objectives: The effect of trace elements zinc Zn , chromium Cr , selenium Se , iron Fe , copper Cu , vanadium Va on the glucose metabolism is known. The aim of this study was to determine the relationship between trace element levels and acute diabetes mellitus DM complications in patients presented to the emergency department ED . Patients and Methods: Patients presented to the ED of a university hospital between January and February 2012 over the age of 18 with newly or previously diagnosed DM, were included in the study. The control group was selected from healthy individuals over the age of 18 without any known disease or drug use. Trace element levels were obtained by the atomic absorption spectrophotometric method using the TQ X5 ICP-MS device. Trace element levels were compared between DM and control group as well as between DM complications and control group. Results: A total of 249 124 female patients were included in the study. 151 84 women were in the study group and 98 40 women in the control group. When the measured trace element levels of the diabetic patients were compared with those of the control group, there was no significant difference in the mean values p>0.05 . There was also no significant difference between patients n=11 with acute diabetic complications diabetic ketoacidosis, diabetic ketosis and hyperglycemia and the control group p>0.05 . Conclusion: In this study, no significant difference was found between the trace element levels of the diabetic complications group and those of the control group

Keywords:

Diabetes Mellitus, trace element, zinc, chromium selenium, iron, copper, vanadium,

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